ID I6QDQ4_9HIV1 Unreviewed; 90 AA. AC I6QDQ4; DT 03-OCT-2012, integrated into UniProtKB/TrEMBL. DT 03-OCT-2012, sequence version 1. DT 20-DEC-2017, entry version 19. DE RecName: Full=Protein Rev {ECO:0000256|RuleBase:RU364044, ECO:0000256|SAAS:SAAS00407638}; DE AltName: Full=Regulator of expression of viral proteins {ECO:0000256|RuleBase:RU364044}; DE Flags: Fragment; GN Name=rev {ECO:0000256|RuleBase:RU364044, ECO:0000313|EMBL:AFK88280.1}; OS Human immunodeficiency virus 1. OC Viruses; Retro-transcribing viruses; Retroviridae; Orthoretrovirinae; OC Lentivirus; Primate lentivirus group. OX NCBI_TaxID=11676 {ECO:0000313|EMBL:AFK88280.1}; OH NCBI_TaxID=9606; Homo sapiens (Human). RN [1] {ECO:0000313|EMBL:AFK88280.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=CH58wk4.3B3 {ECO:0000313|EMBL:AFK88280.1}; RX PubMed=22693447; DOI=10.1371/journal.ppat.1002721; RA Bar K.J., Tsao C.Y., Iyer S.S., Decker J.M., Yang Y., Bonsignori M., RA Chen X., Hwang K.K., Montefiori D.C., Liao H.X., Hraber P., RA Fischer W., Li H., Wang S., Sterrett S., Keele B.F., Ganusov V.V., RA Perelson A.S., Korber B.T., Georgiev I., McLellan J.S., Pavlicek J.W., RA Gao F., Haynes B.F., Hahn B.H., Kwong P.D., Shaw G.M.; RT "Early Low-Titer Neutralizing Antibodies Impede HIV-1 Replication and RT Select for Virus Escape."; RL PLoS Pathog. 8:E1002721-E1002721(2012). CC -!- FUNCTION: Escorts unspliced or incompletely spliced viral pre- CC mRNAs (late transcripts) out of the nucleus of infected cells. CC These pre-mRNAs carry a recognition sequence called Rev responsive CC element (RRE) located in the env gene, that is not present in CC fully spliced viral mRNAs (early transcripts). This function is CC essential since most viral proteins are translated from unspliced CC or partially spliced pre-mRNAs which cannot exit the nucleus by CC the pathway used by fully processed cellular mRNAs. CC {ECO:0000256|RuleBase:RU364044, ECO:0000256|SAAS:SAAS00857321}. CC -!- SUBUNIT: Homomultimer; when bound to the RRE. Multimeric assembly CC is essential for activity. {ECO:0000256|RuleBase:RU364044, CC ECO:0000256|SAAS:SAAS00592583}. CC -!- SUBCELLULAR LOCATION: Host cytoplasm CC {ECO:0000256|RuleBase:RU364044}. Host nucleus, host nucleolus CC {ECO:0000256|RuleBase:RU364044, ECO:0000256|SAAS:SAAS00592582}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; JQ957745; AFK88280.1; -; Genomic_RNA. DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0044196; C:host cell nucleolus; IEA:UniProtKB-SubCell. DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW. DR GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IEA:InterPro. DR GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW. DR InterPro; IPR000625; REV_protein. DR Pfam; PF00424; REV; 1. PE 4: Predicted; KW Host cytoplasm {ECO:0000256|RuleBase:RU364044, KW ECO:0000256|SAAS:SAAS00486079}; KW Host nucleus {ECO:0000256|RuleBase:RU364044, KW ECO:0000256|SAAS:SAAS00486044}; KW mRNA transport {ECO:0000256|RuleBase:RU364044, KW ECO:0000256|SAAS:SAAS00486068}; KW RNA-binding {ECO:0000256|RuleBase:RU364044, KW ECO:0000256|SAAS:SAAS00486057}; KW Transport {ECO:0000256|RuleBase:RU364044, KW ECO:0000256|SAAS:SAAS00486084}. FT NON_TER 1 1 {ECO:0000313|EMBL:AFK88280.1}. SQ SEQUENCE 90 AA; 9975 MW; 0205AEE207F29122 CRC64; PPPSSEGTRQ ARRNRRRRWR ERQRQIQRIS GWILSTYLGR SAEPVPLPLP PLERLTLGSN EDCGTSGSQG VGSPQVLVES PAVLESGTKE //