ID I3ZN84_HUMAN Unreviewed; 362 AA. AC I3ZN84; DT 05-SEP-2012, integrated into UniProtKB/TrEMBL. DT 05-SEP-2012, sequence version 1. DT 03-JUL-2019, entry version 52. DE SubName: Full=MHC class I antigen {ECO:0000313|EMBL:AFL91488.1}; GN Name=HLA-B {ECO:0000313|EMBL:AFL91488.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:AFL91488.1}; RN [1] {ECO:0000313|EMBL:AFL91488.1} RP NUCLEOTIDE SEQUENCE. RA Lind C., Ferriola D., Mackiewicz K., Sasson A., Monos D.; RT "Full genomic sequencing of 15 common and well-documented HLA class I RT alleles using next generation sequencing technology."; RL Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:ALZ40818.1} RP NUCLEOTIDE SEQUENCE. RA Bravo-Egana V., Clark P., Monos D.; RT "Generation of high confidence HLA genotyping and consensus sequences RT for Class I HLA loci using the NGS-based Omixon Holotype HLA typing RT system and the Illumina MiSeq platform."; RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|EMBL:ANG08746.1} RP NUCLEOTIDE SEQUENCE. RA Barsakis K., Babrzadeh F., Chi A., Mindrinos M.N., RA Fernandez Vina M.A.; RT "HLA variation in coding and non-coding gene segments."; RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases. RN [4] {ECO:0000313|EMBL:ASA39912.1} RP NUCLEOTIDE SEQUENCE. RA Varghese N.; RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases. RN [5] {ECO:0000313|EMBL:SBW38437.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=28547825; DOI=10.1111/tan.13057; RA Albrecht V., Zweiniger C., Surendranath V., Lang K., Schofl G., RA Dahl A., Winkler S., Lange V., Bohme I., Schmidt A.H.; RT "Dual redundant sequencing strategy: Full-length gene characterisation RT of 1056 novel and confirmatory HLA alleles."; RL HLA 90:79-87(2017). RN [6] {ECO:0000213|PDB:5VVP} RP X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 25-300, AND DISULFIDE BONDS. RX PubMed=30410026; DOI=10.1038/s41467-018-07109-w; RA Illing P.T., Pymm P., Croft N.P., Hilton H.G., Jojic V., Han A.S., RA Mendoza J.L., Mifsud N.A., Dudek N.L., McCluskey J., Parham P., RA Rossjohn J., Vivian J.P., Purcell A.W.; RT "HLA-B57 micropolymorphism defines the sequence and conformational RT breadth of the immunopeptidome."; RL Nat. Commun. 9:4693-4693(2018). RN [7] {ECO:0000313|EMBL:SPS03132.1} RP NUCLEOTIDE SEQUENCE. RA Lanie J.A., Ng W.-L., Kazmierczak K.M., Andrzejewski T.M., RA Davidsen T.M., Wayne K.J., Tettelin H., Glass J.I., Rusch D., RA Podicherti R., Tsui H.-C.T., Winkler M.E.; RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439, ECO:0000256|SAAS:SAAS00560993}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; JQ771786; AFL91488.1; -; Genomic_DNA. DR EMBL; KU528603; ALZ40818.1; -; Genomic_DNA. DR EMBL; KU319331; ANG08746.1; -; Genomic_DNA. DR EMBL; KU319332; ANG08747.1; -; Genomic_DNA. DR EMBL; KY000094; ASA39912.1; -; Genomic_DNA. DR EMBL; LT599216; SBW38437.1; -; Genomic_DNA. DR EMBL; LS423034; SPS03132.1; -; Genomic_DNA. DR PDB; 5VVP; X-ray; 2.00 A; A=25-300. DR PDBsum; 5VVP; -. DR ChiTaRS; HLA-B; human. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW 3D-structure {ECO:0000213|PDB:5VVP}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00292284}; KW Immunity {ECO:0000256|SAAS:SAAS00292276}; KW Membrane {ECO:0000256|SAAS:SAAS00291594, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00291591}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00298758, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00292275, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 362 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014305270. FT TRANSMEM 308 330 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 209 295 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT REGION 337 362 Disordered. {ECO:0000256|MobiDB-lite: FT I3ZN84}. FT COMPBIAS 339 362 Polar. {ECO:0000256|MobiDB-lite:I3ZN84}. FT DISULFID 125 188 {ECO:0000213|PDB:5VVP}. FT DISULFID 227 283 {ECO:0000213|PDB:5VVP}. SQ SEQUENCE 362 AA; 40299 MW; 45C98B4CD2F28B31 CRC64; MRVTAPRTVL LLLWGAVALT ETWAGSHSMR YFYTAMSRPG RGEPRFIAVG YVDDTQFVRF DSDAASPRMA PRAPWIEQEG PEYWDGETRN MKASAQTYRE NLRIALRYYN QSEAGSHIIQ VMYGCDVGPD GRLLRGHNQY AYDGKDYIAL NEDLSSWTAA DTAAQITQRK WEAARVAEQL RAYLEGLCVE WLRRYLENGK ETLQRADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP SSQSTVPIVG IVAGLAVLAV VVIGAVVAAV MCRRKSSGGK GGSYSQAACS DSAQGSDVSL TA //