ID I3ZN84_HUMAN Unreviewed; 362 AA. AC I3ZN84; DT 05-SEP-2012, integrated into UniProtKB/TrEMBL. DT 05-SEP-2012, sequence version 1. DT 01-OCT-2014, entry version 11. DE SubName: Full=MHC class I antigen {ECO:0000313|EMBL:AFL91488.1}; GN Name=HLA-B {ECO:0000313|EMBL:AFL91488.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:AFL91488.1}; RN [1] {ECO:0000313|EMBL:AFL91488.1} RP NUCLEOTIDE SEQUENCE. RA Lind C., Ferriola D., Mackiewicz K., Sasson A., Monos D.; RT "Full genomic sequencing of 15 common and well-documented HLA class I RT alleles using next generation sequencing technology."; RL Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00096129}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC -!- SIMILARITY: Contains Ig-like C1-type (immunoglobulin-like) domain. CC {ECO:0000256|SAAS:SAAS00096055}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; JQ771786; AFL91488.1; -; Genomic_DNA. DR ProteinModelPortal; I3ZN84; -. DR PRIDE; I3ZN84; -. DR ChiTaRS; HLA-B; human. DR NextBio; 35533722; -. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0042605; F:peptide antigen binding; IEA:InterPro. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR GO; GO:0001916; P:positive regulation of T cell mediated cytotoxicity; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR027648; MHC_I_a. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Disulfide bond {ECO:0000256|SAAS:SAAS00096132}; KW Immunity {ECO:0000256|SAAS:SAAS00096065}; KW Membrane {ECO:0000256|SAAS:SAAS00096038}; KW MHC I {ECO:0000256|SAAS:SAAS00096118}; KW Transmembrane {ECO:0000256|SAAS:SAAS00096125}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00096109}. SQ SEQUENCE 362 AA; 40299 MW; 45C98B4CD2F28B31 CRC64; MRVTAPRTVL LLLWGAVALT ETWAGSHSMR YFYTAMSRPG RGEPRFIAVG YVDDTQFVRF DSDAASPRMA PRAPWIEQEG PEYWDGETRN MKASAQTYRE NLRIALRYYN QSEAGSHIIQ VMYGCDVGPD GRLLRGHNQY AYDGKDYIAL NEDLSSWTAA DTAAQITQRK WEAARVAEQL RAYLEGLCVE WLRRYLENGK ETLQRADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP SSQSTVPIVG IVAGLAVLAV VVIGAVVAAV MCRRKSSGGK GGSYSQAACS DSAQGSDVSL TA //