ID   I3QIS2_PRRSV            Unreviewed;      2473 AA.
AC   I3QIS2;
DT   05-SEP-2012, integrated into UniProtKB/TrEMBL.
DT   05-SEP-2012, sequence version 1.
DT   22-FEB-2023, entry version 42.
DE   SubName: Full=Non-structural protein {ECO:0000313|EMBL:AFK09059.1};
OS   Porcine reproductive and respiratory syndrome virus (PRRSV).
OC   Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC   Nidovirales; Arnidovirineae; Arteriviridae.
OX   NCBI_TaxID=28344 {ECO:0000313|EMBL:AFK09059.1, ECO:0000313|Proteomes:UP000152673};
OH   NCBI_TaxID=9823; Sus scrofa (Pig).
RN   [1] {ECO:0000313|EMBL:AFK09059.1, ECO:0000313|Proteomes:UP000152673}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=10-10FUJ-4 {ECO:0000313|EMBL:AFK09059.1};
RX   PubMed=22525010; DOI=10.1016/j.vetmic.2012.02.036;
RA   Yu X., Chen N., Wang L., Wu J., Zhou Z., Ni J., Li X., Zhai X., Shi J.,
RA   Tian K.;
RT   "New genomic characteristics of highly pathogenic porcine reproductive and
RT   respiratory syndrome viruses do not lead to significant changes in
RT   pathogenicity.";
RL   Vet. Microbiol. 158:291-299(2012).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Host
CC       cytoplasm {ECO:0000256|ARBA:ARBA00004192}. Host membrane
CC       {ECO:0000256|ARBA:ARBA00004301}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004301}. Host nucleus
CC       {ECO:0000256|ARBA:ARBA00004147}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}. Nucleus
CC       {ECO:0000256|ARBA:ARBA00004123}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; JQ663549; AFK09059.1; -; Genomic_RNA.
DR   Proteomes; UP000152673; Genome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-KW.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   GO; GO:0019082; P:viral protein processing; IEA:InterPro.
DR   Gene3D; 3.90.70.160; -; 1.
DR   Gene3D; 4.10.80.390; -; 1.
DR   Gene3D; 3.30.1330.220; Arterivirus nonstructural protein 7 alpha; 1.
DR   Gene3D; 2.30.31.30; Arterivirus nps1beta, nuclease domain; 1.
DR   Gene3D; 3.90.70.70; Arterivirus papain-like cysteine protease beta domain; 1.
DR   Gene3D; 3.90.70.60; Porcine arterivirus-type cysteine proteinase alpha domain; 1.
DR   Gene3D; 2.40.10.10; Trypsin-like serine proteases; 2.
DR   InterPro; IPR031932; Arteri_nsp7a.
DR   InterPro; IPR038451; Arteri_nsp7a_sf.
DR   InterPro; IPR008743; Arterivirus_Nsp2_C33.
DR   InterPro; IPR023338; Arterivirus_NSP4_peptidase.
DR   InterPro; IPR008741; AV_PCPalpha.
DR   InterPro; IPR038155; AV_PCPalpha_sf.
DR   InterPro; IPR025773; AV_PCPbeta.
DR   InterPro; IPR038154; AV_PCPbeta_sf.
DR   InterPro; IPR023183; Chymotrypsin-like_C.
DR   InterPro; IPR008760; EAV_peptidase_S32.
DR   InterPro; IPR032855; NSP2-B_epitope.
DR   InterPro; IPR032785; Pdase_C33_assoc.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR   Pfam; PF16749; Arteri_nsp7a; 1.
DR   Pfam; PF14757; NSP2-B_epitope; 2.
DR   Pfam; PF14756; Pdase_C33_assoc; 1.
DR   Pfam; PF05410; Peptidase_C31; 1.
DR   Pfam; PF05411; Peptidase_C32; 1.
DR   Pfam; PF05412; Peptidase_C33; 1.
DR   Pfam; PF05579; Peptidase_S32; 1.
DR   SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR   PROSITE; PS51538; AV_CP; 1.
DR   PROSITE; PS51493; AV_NSP4_PRO; 1.
DR   PROSITE; PS51539; AV_PCP_ALPHA; 1.
DR   PROSITE; PS51540; AV_PCP_BETA; 1.
PE   4: Predicted;
KW   Host cytoplasm {ECO:0000256|ARBA:ARBA00023200};
KW   Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW   Host nucleus {ECO:0000256|ARBA:ARBA00022562};
KW   Host-virus interaction {ECO:0000256|ARBA:ARBA00022632};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Inhibition of host innate immune response by virus
KW   {ECO:0000256|ARBA:ARBA00022632};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Protease {ECO:0000256|ARBA:ARBA00022670};
KW   Ribosomal frameshifting {ECO:0000256|ARBA:ARBA00022758};
KW   Serine protease {ECO:0000256|ARBA:ARBA00022825};
KW   Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius};
KW   Viral immunoevasion {ECO:0000256|ARBA:ARBA00023280};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT   TRANSMEM        1228..1256
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1263..1279
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1341..1359
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1618..1642
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1654..1682
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1688..1717
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1992..2017
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        2029..2050
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        2062..2082
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        2102..2127
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        2134..2152
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          69..180
FT                   /note="Peptidase C31"
FT                   /evidence="ECO:0000259|PROSITE:PS51539"
FT   DOMAIN          263..383
FT                   /note="Peptidase C32"
FT                   /evidence="ECO:0000259|PROSITE:PS51540"
FT   DOMAIN          428..535
FT                   /note="Peptidase C33"
FT                   /evidence="ECO:0000259|PROSITE:PS51538"
FT   DOMAIN          1780..1983
FT                   /note="Peptidase S32"
FT                   /evidence="ECO:0000259|PROSITE:PS51493"
FT   REGION          401..422
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          809..865
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1122..1149
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        401..417
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        825..841
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   2473 AA;  268852 MW;  B1AFA0CE8A651A86 CRC64;
     MSGILDRCTC TPNARVFVAE GQVYCTRCLS ARSLLPLNLQ VPELGVLGLF YRPEEPLRWT
     LPRAFPTVEC SPAGACWLSA IFPIARMTSG NLNFQQRMVR VAAEIYRAGQ LTPTVLKTLQ
     VYERGCRWYP IVGPVPGVGV YANSLHVSDK PFPGATHVLT NLPLPQRPKP EDFCPFECAM
     ADVYDIGRGA VMYVAGGKVS WAPRGGNEVK FEPVPKELRL VASRLHTSFP PHHVVDMSRF
     TFMTPGSGVS MRVEYQCGCL PADTVPEGNC WWRLFDSLPP EVQYKEIRHA NQFGYQTKHG
     VPGKYLQRRL QVNGLRAVTD THGPIVIQYF SVKESWIRHL KLVEEPSLPG FEDLLRIRVE
     PNTSPLVGKD EKIFRFGSHK WYGAGKRARK TRSGATTVVA HHASSAHETQ QATKHEGTGA
     NKAEHLKRYS PPAEGNCGWH CISAIANRMV NSNFETTLPE RARPSDDWAT DEDLVNTIQI
     LRLPAALDRN GACGSAKYVL KLEGEHWTVS VIPGMSPTLL PLECVQGCCE HKGGLVSSDA
     VEISEFDPAC LDRLAKVMHL PSSAIPAALA ELSDDSNRPV SPAATTWTVS QFYARHGGGD
     HHDQVCLGKI ISLCQVIEDC CCHQNKTNRA TPEEVAAKID QYLRGATSLE ECLAKLERVS
     PPGAADTSFD WNVVLPGVEA ASQTTEQPHV NSCCTLVPPV TQEPLGKDSV PLTAFSLSNC
     YYPAQGDEVH HRERLNSVLS RLEEVVMEEY GLMPTGLGPR PVLPSGLDEL KDQMEEDLLK
     LANTQATSEM MARAAEQVDL KAWVKSYPRW APPPPPPRVQ PRRTKSVKSL PEDKPVPAPR
     RKVRSDCGGP VLMGDNVPNG SEETVGGPLN FPTPSELMTP MSEPVLVPAS QFVPKLMTPL
     IGSAPVPAPR RTVTTTLTHL DEPLDLSASS QTEYKASPLA PSQNMGILVA GGQEAEEVLS
     EISDILNDTN PAPVSSSSSL SSVKITRPKY SAQAIIDSGG PCSGHLQKEK EACLSIMREA
     CDASKLSDPA TQEWLSRMWD RVDMLTWRNT SAYQAFRILN GRFGFLPKMI LETPPPYPCG
     FVMLPHTPAP SVSAESDLTI GSVATEDVPR ILGKIGDTNE LLDRGPLAPS KGEPVCDQPA
     KDPLMSPRES DESIIAPPAD TGGVGSFTDL PSSDGVDVDG GGLLRTVKTK AGRLLDQLSC
     QVFSLVSHLP IFFSHLFKSD SGYSPGDWGF AAFTLFCLFL CYSYPFFGFA PLLGVFSGSS
     RRVRMGVFGC WLAFAVGLFK PVSDPVGNAC EFDSPECRNV LHSFELLKPW DPVRSLVVGP
     VGLGLAILGR LLGGARYVWH FLLRLGIVAD CILAGAYVLS QGRCKKCWGS CVRTAPNEIA
     FNVFPFTRAT RSSLIDLCDR FCAPKGMDPI FLATGWRGCW TGRSPIEQPS EKPIAFAQLD
     EKRITARTVV AQPYDPNQAV KCLRVLQAGG AMVAETVPKV VKVSAIPFRA PFFPAGVKVD
     PECRIVVDPD TFTTALRSGY STANLVLGTG DFAQLNGLKI RQISKPSGGG PHLIAALHVA
     CSMALHMLAG VYVTAVGSCG TGTNDPWCTN PFAVPGYGPG SLCTSRLCIS QHGLTLPLTA
     LVVGFGLQEI ALVVLIFVSV GGMAHRLSCK ADMLCILLAI ASYVWVPLTW LLCVFPCWLR
     WFSLHPLTIL WLVFFLISVN IPSGILAVVL LVSLWLLGRY TNIAGLVTPY DIHHYTSGPR
     GVAALATAPD GTYLAAVRRA ALTGRTMLFT PSQLGSLLEG AFRTQKPSLN TVNVVGSSMG
     SGGVFTIDGK IKCVTAAHVL TGNSARVSGV GFNQMLDFDV KGDFAIADCP NWQGVAPKAQ
     FCEDGWTGRA YWLTSSGVEP GVIGNGFAFC FTACGDSGSP VITEAGELVG VHTGSNKQGG
     GIVTRPSGQF RNVEPIKLSE LSEFFAGPKV PLGDVKIGSH IIKDTCEVPS DLCALLAAKP
     ELEGGLSTVQ RLCVFFLLWR MMGHAWTPLV AVGFFILNEI LPAVLVRSVF SFGMFVLSWL
     TPWSAQVLMI RLLTAALNRN RWSLGFYSLG AVTSFVADLA VTQGHPLQVV MNLSTYAFLP
     RMMVMTSPVP VIACGVVHLL AIILYLFKYR CLHNVLVGDG VFSSAFFLRY FAEGKLREGV
     SQSCGMSHES LTGALAMRLT DEDLDFLTKW TDFKCFVSAS NMRNAAGQFI EAAYAKALRI
     ELAQLVQVDK VRGTMAKLEA FADTVAPQLS PGDIVVALGH TPVGSIFDLK VGSTKHTLQA
     IETRVLAGSK MTVARVVDPT PAPPPVPVPI PLPPKVLENG PNAWGDEDRL NKKKRRRMEA
     VGIFVMDGKK YQKFWDKNSG DVFYEEVHIS TDEWECLRTG DPVDFDPETG IQCGHITIED
     KVYNVFTSPS GRRFLVPANP ENRRAQWEAA KLSVEQALGM MNVDGELTAK ELEKLKRIID
     KLQGLTKEQC LNC
//