ID I3QIS2_PRRSV Unreviewed; 2473 AA. AC I3QIS2; DT 05-SEP-2012, integrated into UniProtKB/TrEMBL. DT 05-SEP-2012, sequence version 1. DT 18-JAN-2017, entry version 14. DE SubName: Full=Non-structural protein {ECO:0000313|EMBL:AFK09059.1}; OS Porcine reproductive and respiratory syndrome virus (PRRSV). OC Viruses; ssRNA viruses; ssRNA positive-strand viruses, no DNA stage; OC Nidovirales; Arteriviridae; Arterivirus. OX NCBI_TaxID=28344 {ECO:0000313|EMBL:AFK09059.1, ECO:0000313|Proteomes:UP000152673}; OH NCBI_TaxID=9823; Sus scrofa (Pig). RN [1] {ECO:0000313|EMBL:AFK09059.1, ECO:0000313|Proteomes:UP000152673} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=10-10FUJ-4 {ECO:0000313|EMBL:AFK09059.1}; RX PubMed=22525010; DOI=10.1016/j.vetmic.2012.02.036; RA Yu X., Chen N., Wang L., Wu J., Zhou Z., Ni J., Li X., Zhai X., RA Shi J., Tian K.; RT "New genomic characteristics of highly pathogenic porcine reproductive RT and respiratory syndrome viruses do not lead to significant changes in RT pathogenicity."; RL Vet. Microbiol. 158:291-299(2012). CC -!- SIMILARITY: Contains 1 peptidase S32 domain. {ECO:0000256|PROSITE- CC ProRule:PRU00826}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; JQ663549; AFK09059.1; -; Genomic_RNA. DR Proteomes; UP000152673; Genome. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro. DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro. DR GO; GO:0019082; P:viral protein processing; IEA:InterPro. DR InterPro; IPR031932; Arteri_nsp7a. DR InterPro; IPR008743; Arterivirus_Nsp2_C33. DR InterPro; IPR023338; Arterivirus_NSP4_peptidase. DR InterPro; IPR008741; AV_PCPalpha. DR InterPro; IPR025773; AV_PCPbeta. DR InterPro; IPR008760; EAV_peptidase_S32. DR InterPro; IPR032855; NSP2-B_epitope. DR InterPro; IPR032785; Pdase_C33_assoc. DR InterPro; IPR009003; Peptidase_S1_PA. DR Pfam; PF16749; Arteri_nsp7a; 1. DR Pfam; PF14757; NSP2-B_epitope; 2. DR Pfam; PF14756; Pdase_C33_assoc; 1. DR Pfam; PF05410; Peptidase_C31; 1. DR Pfam; PF05411; Peptidase_C32; 1. DR Pfam; PF05412; Peptidase_C33; 1. DR Pfam; PF05579; Peptidase_S32; 1. DR SUPFAM; SSF50494; SSF50494; 1. DR PROSITE; PS51538; AV_CP; 1. DR PROSITE; PS51493; AV_NSP4_PRO; 1. DR PROSITE; PS51539; AV_PCP_ALPHA; 1. DR PROSITE; PS51540; AV_PCP_BETA; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000152673}; KW Hydrolase {ECO:0000256|PROSITE-ProRule:PRU00826}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Protease {ECO:0000256|PROSITE-ProRule:PRU00826}; KW Serine protease {ECO:0000256|PROSITE-ProRule:PRU00826}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 1228 1256 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 1263 1279 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 1341 1359 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 1618 1642 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 1654 1682 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 1688 1717 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 1992 2017 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 2029 2050 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 2062 2082 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 2102 2127 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 2134 2152 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 69 180 Peptidase C31. {ECO:0000259|PROSITE: FT PS51539}. FT DOMAIN 263 383 Peptidase C32. {ECO:0000259|PROSITE: FT PS51540}. FT DOMAIN 428 535 Peptidase C33. {ECO:0000259|PROSITE: FT PS51538}. FT DOMAIN 1780 1983 Peptidase S32. {ECO:0000259|PROSITE: FT PS51493}. FT ACT_SITE 1818 1818 Charge relay system; for 3C-like serine FT proteinase activity. FT {ECO:0000256|PROSITE-ProRule:PRU00826}. FT ACT_SITE 1843 1843 Charge relay system; for 3C-like serine FT proteinase activity. FT {ECO:0000256|PROSITE-ProRule:PRU00826}. FT ACT_SITE 1897 1897 Charge relay system; for 3C-like serine FT proteinase activity. FT {ECO:0000256|PROSITE-ProRule:PRU00826}. SQ SEQUENCE 2473 AA; 268852 MW; B1AFA0CE8A651A86 CRC64; MSGILDRCTC TPNARVFVAE GQVYCTRCLS ARSLLPLNLQ VPELGVLGLF YRPEEPLRWT LPRAFPTVEC SPAGACWLSA IFPIARMTSG NLNFQQRMVR VAAEIYRAGQ LTPTVLKTLQ VYERGCRWYP IVGPVPGVGV YANSLHVSDK PFPGATHVLT NLPLPQRPKP EDFCPFECAM ADVYDIGRGA VMYVAGGKVS WAPRGGNEVK FEPVPKELRL VASRLHTSFP PHHVVDMSRF TFMTPGSGVS MRVEYQCGCL PADTVPEGNC WWRLFDSLPP EVQYKEIRHA NQFGYQTKHG VPGKYLQRRL QVNGLRAVTD THGPIVIQYF SVKESWIRHL KLVEEPSLPG FEDLLRIRVE PNTSPLVGKD EKIFRFGSHK WYGAGKRARK TRSGATTVVA HHASSAHETQ QATKHEGTGA NKAEHLKRYS PPAEGNCGWH CISAIANRMV NSNFETTLPE RARPSDDWAT DEDLVNTIQI LRLPAALDRN GACGSAKYVL KLEGEHWTVS VIPGMSPTLL PLECVQGCCE HKGGLVSSDA VEISEFDPAC LDRLAKVMHL PSSAIPAALA ELSDDSNRPV SPAATTWTVS QFYARHGGGD HHDQVCLGKI ISLCQVIEDC CCHQNKTNRA TPEEVAAKID QYLRGATSLE ECLAKLERVS PPGAADTSFD WNVVLPGVEA ASQTTEQPHV NSCCTLVPPV TQEPLGKDSV PLTAFSLSNC YYPAQGDEVH HRERLNSVLS RLEEVVMEEY GLMPTGLGPR PVLPSGLDEL KDQMEEDLLK LANTQATSEM MARAAEQVDL KAWVKSYPRW APPPPPPRVQ PRRTKSVKSL PEDKPVPAPR RKVRSDCGGP VLMGDNVPNG SEETVGGPLN FPTPSELMTP MSEPVLVPAS QFVPKLMTPL IGSAPVPAPR RTVTTTLTHL DEPLDLSASS QTEYKASPLA PSQNMGILVA GGQEAEEVLS EISDILNDTN PAPVSSSSSL SSVKITRPKY SAQAIIDSGG PCSGHLQKEK EACLSIMREA CDASKLSDPA TQEWLSRMWD RVDMLTWRNT SAYQAFRILN GRFGFLPKMI LETPPPYPCG FVMLPHTPAP SVSAESDLTI GSVATEDVPR ILGKIGDTNE LLDRGPLAPS KGEPVCDQPA KDPLMSPRES DESIIAPPAD TGGVGSFTDL PSSDGVDVDG GGLLRTVKTK AGRLLDQLSC QVFSLVSHLP IFFSHLFKSD SGYSPGDWGF AAFTLFCLFL CYSYPFFGFA PLLGVFSGSS RRVRMGVFGC WLAFAVGLFK PVSDPVGNAC EFDSPECRNV LHSFELLKPW DPVRSLVVGP VGLGLAILGR LLGGARYVWH FLLRLGIVAD CILAGAYVLS QGRCKKCWGS CVRTAPNEIA FNVFPFTRAT RSSLIDLCDR FCAPKGMDPI FLATGWRGCW TGRSPIEQPS EKPIAFAQLD EKRITARTVV AQPYDPNQAV KCLRVLQAGG AMVAETVPKV VKVSAIPFRA PFFPAGVKVD PECRIVVDPD TFTTALRSGY STANLVLGTG DFAQLNGLKI RQISKPSGGG PHLIAALHVA CSMALHMLAG VYVTAVGSCG TGTNDPWCTN PFAVPGYGPG SLCTSRLCIS QHGLTLPLTA LVVGFGLQEI ALVVLIFVSV GGMAHRLSCK ADMLCILLAI ASYVWVPLTW LLCVFPCWLR WFSLHPLTIL WLVFFLISVN IPSGILAVVL LVSLWLLGRY TNIAGLVTPY DIHHYTSGPR GVAALATAPD GTYLAAVRRA ALTGRTMLFT PSQLGSLLEG AFRTQKPSLN TVNVVGSSMG SGGVFTIDGK IKCVTAAHVL TGNSARVSGV GFNQMLDFDV KGDFAIADCP NWQGVAPKAQ FCEDGWTGRA YWLTSSGVEP GVIGNGFAFC FTACGDSGSP VITEAGELVG VHTGSNKQGG GIVTRPSGQF RNVEPIKLSE LSEFFAGPKV PLGDVKIGSH IIKDTCEVPS DLCALLAAKP ELEGGLSTVQ RLCVFFLLWR MMGHAWTPLV AVGFFILNEI LPAVLVRSVF SFGMFVLSWL TPWSAQVLMI RLLTAALNRN RWSLGFYSLG AVTSFVADLA VTQGHPLQVV MNLSTYAFLP RMMVMTSPVP VIACGVVHLL AIILYLFKYR CLHNVLVGDG VFSSAFFLRY FAEGKLREGV SQSCGMSHES LTGALAMRLT DEDLDFLTKW TDFKCFVSAS NMRNAAGQFI EAAYAKALRI ELAQLVQVDK VRGTMAKLEA FADTVAPQLS PGDIVVALGH TPVGSIFDLK VGSTKHTLQA IETRVLAGSK MTVARVVDPT PAPPPVPVPI PLPPKVLENG PNAWGDEDRL NKKKRRRMEA VGIFVMDGKK YQKFWDKNSG DVFYEEVHIS TDEWECLRTG DPVDFDPETG IQCGHITIED KVYNVFTSPS GRRFLVPANP ENRRAQWEAA KLSVEQALGM MNVDGELTAK ELEKLKRIID KLQGLTKEQC LNC //