ID I3L390_HUMAN Unreviewed; 208 AA. AC I3L390; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 09-JAN-2013, sequence version 2. DT 13-SEP-2023, entry version 57. DE SubName: Full=SMG6 nonsense mediated mRNA decay factor {ECO:0000313|Ensembl:ENSP00000460273.2}; DE Flags: Fragment; GN Name=SMG6 {ECO:0000313|Ensembl:ENSP00000460273.2}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000460273.2, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000460273.2, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16625196; DOI=10.1038/nature04689; RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., RA Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J., RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.; RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the RT human lineage."; RL Nature 440:1045-1049(2006). RN [2] {ECO:0000313|Ensembl:ENSP00000460273.2} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2023) to UniProtKB. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC090617; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL450226; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KF456221; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KF456223; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KF456224; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KF456235; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR AlphaFoldDB; I3L390; -. DR SMR; I3L390; -. DR MaxQB; I3L390; -. DR PeptideAtlas; I3L390; -. DR ProteomicsDB; 47159; -. DR Antibodypedia; 50527; 90 antibodies from 14 providers. DR Ensembl; ENST00000575454.1; ENSP00000460273.2; ENSG00000070366.14. DR UCSC; uc059zle.1; human. DR HGNC; HGNC:17809; SMG6. DR VEuPathDB; HostDB:ENSG00000070366; -. DR GeneTree; ENSGT00940000155300; -. DR HOGENOM; CLU_1323539_0_0_1; -. DR ChiTaRS; SMG6; human. DR Proteomes; UP000005640; Chromosome 17. DR Bgee; ENSG00000070366; Expressed in stromal cell of endometrium and 123 other tissues. DR ExpressionAtlas; I3L390; baseline and differential. DR InterPro; IPR045153; Est1/Ebs1-like. DR InterPro; IPR011990; TPR-like_helical_dom_sf. DR PANTHER; PTHR15696; SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7; 1. DR PANTHER; PTHR15696:SF0; TELOMERASE-BINDING PROTEIN EST1A; 1. DR SUPFAM; SSF48452; TPR-like; 1. PE 1: Evidence at protein level; KW Proteomics identification {ECO:0007829|EPD:I3L390, KW ECO:0007829|MaxQB:I3L390}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1..20 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 21..208 FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5003674938" FT REGION 189..208 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT NON_TER 208 FT /evidence="ECO:0000313|Ensembl:ENSP00000460273.2" SQ SEQUENCE 208 AA; 23279 MW; 7AD4D3D39871CE60 CRC64; MTGPCIRQLS LQILFPLCVA VDVWSTLADF CNILTAVNQS EVPLYKDPDD DLTLLILEED RLLSGFVPLL AAPQDPCYVE KTSDKVIAAD CKRVTVLKYF LEALCGQEEP LLAFKGGKYV SVAPVPDTMG KEMGSQEGTR LEDEEEDVVI EDFEEDSEAE GSGGEDDIRE LRAKKLALAR KIAEQQRRQE KIQAVLEDHS QMRQMELE //