ID I3L390_HUMAN Unreviewed; 208 AA. AC I3L390; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 09-JAN-2013, sequence version 2. DT 19-JAN-2022, entry version 50. DE SubName: Full=Telomerase-binding protein EST1A {ECO:0000313|Ensembl:ENSP00000460273}; DE Flags: Fragment; GN Name=SMG6 {ECO:0000313|Ensembl:ENSP00000460273}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000460273, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000460273, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16625196; DOI=10.1038/nature04689; RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., RA Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J., RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.; RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the RT human lineage."; RL Nature 440:1045-1049(2006). RN [2] {ECO:0000313|Ensembl:ENSP00000460273} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC090617; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL450226; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KF456221; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KF456223; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KF456224; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KF456235; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR SMR; I3L390; -. DR MaxQB; I3L390; -. DR PeptideAtlas; I3L390; -. DR ProteomicsDB; 47159; -. DR Antibodypedia; 50527; 74 antibodies from 14 providers. DR Ensembl; ENST00000575454; ENSP00000460273; ENSG00000070366. DR UCSC; uc059zle.1; human. DR HGNC; HGNC:17809; SMG6. DR OpenTargets; ENSG00000070366; -. DR VEuPathDB; HostDB:ENSG00000070366; -. DR GeneTree; ENSGT00940000155300; -. DR HOGENOM; CLU_1323539_0_0_1; -. DR ChiTaRS; SMG6; human. DR Proteomes; UP000005640; Chromosome 17. DR Bgee; ENSG00000070366; Expressed in right ovary and 176 other tissues. DR ExpressionAtlas; I3L390; baseline and differential. DR InterPro; IPR045153; Est1/Ebs1-like. DR InterPro; IPR011990; TPR-like_helical_dom_sf. DR PANTHER; PTHR15696; PTHR15696; 1. DR SUPFAM; SSF48452; SSF48452; 1. PE 1: Evidence at protein level; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Proteomics identification {ECO:0007829|MaxQB:I3L390, KW ECO:0007829|PeptideAtlas:I3L390}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1..20 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 21..208 FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5003674938" FT REGION 189..208 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COILED 168..188 FT /evidence="ECO:0000256|SAM:Coils" FT NON_TER 208 FT /evidence="ECO:0000313|Ensembl:ENSP00000460273" SQ SEQUENCE 208 AA; 23279 MW; 7AD4D3D39871CE60 CRC64; MTGPCIRQLS LQILFPLCVA VDVWSTLADF CNILTAVNQS EVPLYKDPDD DLTLLILEED RLLSGFVPLL AAPQDPCYVE KTSDKVIAAD CKRVTVLKYF LEALCGQEEP LLAFKGGKYV SVAPVPDTMG KEMGSQEGTR LEDEEEDVVI EDFEEDSEAE GSGGEDDIRE LRAKKLALAR KIAEQQRRQE KIQAVLEDHS QMRQMELE //