ID I3L2X7_HUMAN Unreviewed; 524 AA. AC I3L2X7; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 11-JUL-2012, sequence version 1. DT 25-MAY-2022, entry version 60. DE SubName: Full=Centrosomal protein of 131 kDa {ECO:0000313|Ensembl:ENSP00000460006}; DE Flags: Fragment; GN Name=CEP131 {ECO:0000313|Ensembl:ENSP00000460006}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000460006, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000460006, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16625196; DOI=10.1038/nature04689; RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., RA Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J., RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.; RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the RT human lineage."; RL Nature 440:1045-1049(2006). RN [2] {ECO:0007829|PubMed:19690332} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=19690332; DOI=10.1126/scisignal.2000007; RA Mayya V., Lundgren D.H., Hwang S.I., Rezaul K., Wu L., Eng J.K., RA Rodionov V., Han D.K.; RT "Quantitative phosphoproteomic analysis of T cell receptor signaling RT reveals system-wide modulation of protein-protein interactions."; RL Sci. Signal. 2:RA46-RA46(2009). RN [3] {ECO:0000313|Ensembl:ENSP00000460006} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. RN [4] {ECO:0007829|PubMed:23186163} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=23186163; RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., RA Mohammed S.; RT "Toward a comprehensive characterization of a human cancer cell RT phosphoproteome."; RL J. Proteome Res. 12:260-271(2013). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC027601; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR SMR; I3L2X7; -. DR MaxQB; I3L2X7; -. DR PeptideAtlas; I3L2X7; -. DR PRIDE; I3L2X7; -. DR ProteomicsDB; 47067; -. DR Antibodypedia; 19799; 113 antibodies from 24 providers. DR Ensembl; ENST00000573053.5; ENSP00000460006.1; ENSG00000141577.14. DR UCSC; uc060lhh.1; human. DR HGNC; HGNC:29511; CEP131. DR OpenTargets; ENSG00000141577; -. DR VEuPathDB; HostDB:ENSG00000141577; -. DR GeneTree; ENSGT00390000001758; -. DR HOGENOM; CLU_519671_0_0_1; -. DR ChiTaRS; CEP131; human. DR Proteomes; UP000005640; Chromosome 17. DR Bgee; ENSG00000141577; Expressed in sural nerve and 120 other tissues. DR ExpressionAtlas; I3L2X7; baseline and differential. DR GO; GO:0005929; C:cilium; IEA:GOC. DR GO; GO:0035735; P:intraciliary transport involved in cilium assembly; IEA:InterPro. DR InterPro; IPR030465; CEP131. DR PANTHER; PTHR31540; PTHR31540; 1. PE 1: Evidence at protein level; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Proteomics identification {ECO:0007829|EPD:I3L2X7, KW ECO:0007829|MaxQB:I3L2X7}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}. FT COILED 9..29 FT /evidence="ECO:0000256|SAM:Coils" FT COILED 42..62 FT /evidence="ECO:0000256|SAM:Coils" FT COILED 70..126 FT /evidence="ECO:0000256|SAM:Coils" FT COILED 174..212 FT /evidence="ECO:0000256|SAM:Coils" FT COILED 233..274 FT /evidence="ECO:0000256|SAM:Coils" FT COILED 284..304 FT /evidence="ECO:0000256|SAM:Coils" FT COILED 345..405 FT /evidence="ECO:0000256|SAM:Coils" FT COILED 409..440 FT /evidence="ECO:0000256|SAM:Coils" FT COILED 442..469 FT /evidence="ECO:0000256|SAM:Coils" FT NON_TER 1 FT /evidence="ECO:0000313|Ensembl:ENSP00000460006" SQ SEQUENCE 524 AA; 62015 MW; 705419461DC8D73C CRC64; LGSEVSTSVM RLKLEVEEKK QAMLLLQRAL AQQRDLTARR VKETEKALSR QLQRQREHYE ATIQRHLAFI DQLIEDKKVL SEKCEAVVAE LKQEDQRCTE RVAQAQAQHE LEIKKLKELM SATEKARREK WISEKTKKIK EVTVRGLEPE IQKLIARHKQ EVRRLKSLHE AELLQSDERA SQRCLRQAEE LREQLEREKE ALGQQERERA RQRFQQHLEQ EQWALQQQRQ RLYSEVAEER ERLGQQAARQ RAELEELRQQ LEESSSALTR ALRAEFEKGR EEQERRHQME LNTLKQQLEL ERQAWEAGRT RKERMSPQEA WLLNREQELR EEIRKGRDKE IELVIHRLEA DMALAKEESE KAAESRIKRL RDKYEAELSE LEQSERKLQE RCSELKGQLG EAEGENLRLQ GLVRQKERAL EDAQAVNEQL SSERSNLAQV IRQEFEDRLA ASEEETRQAK AELATLQARQ QLELEEVHRR VKTALARKEE AVSSLRTQHE AAVKRADHLE ELLEQHRRPT PSTK //