ID I3L2X7_HUMAN Unreviewed; 524 AA. AC I3L2X7; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 11-JUL-2012, sequence version 1. DT 25-OCT-2017, entry version 39. DE SubName: Full=Centrosomal protein of 131 kDa {ECO:0000313|Ensembl:ENSP00000460006}; DE Flags: Fragment; GN Name=CEP131 {ECO:0000313|Ensembl:ENSP00000460006}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000460006, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000460006, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16625196; DOI=10.1038/nature04689; RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., RA Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J., RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., RA Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., RA Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., RA Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., RA Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., RA Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., RA Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., RA Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.; RT "DNA sequence of human chromosome 17 and analysis of rearrangement in RT the human lineage."; RL Nature 440:1045-1049(2006). RN [2] {ECO:0000213|PubMed:19690332} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=19690332; DOI=10.1126/scisignal.2000007; RA Mayya V., Lundgren D.H., Hwang S.I., Rezaul K., Wu L., Eng J.K., RA Rodionov V., Han D.K.; RT "Quantitative phosphoproteomic analysis of T cell receptor signaling RT reveals system-wide modulation of protein-protein interactions."; RL Sci. Signal. 2:ra46-RA46(2009). RN [3] {ECO:0000313|Ensembl:ENSP00000460006} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. RN [4] {ECO:0000213|PubMed:23186163} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=23186163; RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., RA Mohammed S.; RT "Toward a comprehensive characterization of a human cancer cell RT phosphoproteome."; RL J. Proteome Res. 12:260-271(2013). CC -!- CAUTION: The sequence shown here is derived from an Ensembl CC automatic analysis pipeline and should be considered as CC preliminary data. {ECO:0000313|Ensembl:ENSP00000460006}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC027601; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; I3L2X7; -. DR MaxQB; I3L2X7; -. DR PaxDb; I3L2X7; -. DR PeptideAtlas; I3L2X7; -. DR PRIDE; I3L2X7; -. DR Ensembl; ENST00000573053; ENSP00000460006; ENSG00000141577. DR UCSC; uc060lhh.1; human. DR EuPathDB; HostDB:ENSG00000141577.13; -. DR HGNC; HGNC:29511; CEP131. DR OpenTargets; ENSG00000141577; -. DR eggNOG; ENOG410IEUN; Eukaryota. DR eggNOG; ENOG410YVPU; LUCA. DR GeneTree; ENSGT00390000001758; -. DR Proteomes; UP000005640; Chromosome 17. DR Bgee; ENSG00000141577; -. DR ExpressionAtlas; I3L2X7; baseline and differential. DR GO; GO:0005929; C:cilium; IEA:GOC. DR GO; GO:0035735; P:intraciliary transport involved in cilium assembly; IEA:InterPro. DR InterPro; IPR030465; CEP131. DR PANTHER; PTHR31540; PTHR31540; 1. PE 1: Evidence at protein level; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Proteomics identification {ECO:0000213|EPD:I3L2X7, KW ECO:0000213|MaxQB:I3L2X7, ECO:0000213|PeptideAtlas:I3L2X7}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}. FT COILED 70 126 {ECO:0000256|SAM:Coils}. FT COILED 174 212 {ECO:0000256|SAM:Coils}. FT COILED 233 274 {ECO:0000256|SAM:Coils}. FT COILED 345 405 {ECO:0000256|SAM:Coils}. FT COILED 409 440 {ECO:0000256|SAM:Coils}. FT COILED 442 469 {ECO:0000256|SAM:Coils}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSP00000460006}. SQ SEQUENCE 524 AA; 62015 MW; 705419461DC8D73C CRC64; LGSEVSTSVM RLKLEVEEKK QAMLLLQRAL AQQRDLTARR VKETEKALSR QLQRQREHYE ATIQRHLAFI DQLIEDKKVL SEKCEAVVAE LKQEDQRCTE RVAQAQAQHE LEIKKLKELM SATEKARREK WISEKTKKIK EVTVRGLEPE IQKLIARHKQ EVRRLKSLHE AELLQSDERA SQRCLRQAEE LREQLEREKE ALGQQERERA RQRFQQHLEQ EQWALQQQRQ RLYSEVAEER ERLGQQAARQ RAELEELRQQ LEESSSALTR ALRAEFEKGR EEQERRHQME LNTLKQQLEL ERQAWEAGRT RKERMSPQEA WLLNREQELR EEIRKGRDKE IELVIHRLEA DMALAKEESE KAAESRIKRL RDKYEAELSE LEQSERKLQE RCSELKGQLG EAEGENLRLQ GLVRQKERAL EDAQAVNEQL SSERSNLAQV IRQEFEDRLA ASEEETRQAK AELATLQARQ QLELEEVHRR VKTALARKEE AVSSLRTQHE AAVKRADHLE ELLEQHRRPT PSTK //