ID I3JF34_ORENI Unreviewed; 276 AA. AC I3JF34; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 11-JUL-2012, sequence version 1. DT 16-MAR-2016, entry version 25. DE RecName: Full=Insulin-induced gene protein {ECO:0000256|RuleBase:RU241113}; GN Name=insig1 {ECO:0000313|Ensembl:ENSONIP00000007475}; OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids; OC Pseudocrenilabrinae; Oreochromini; Oreochromis. OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000007475, ECO:0000313|Proteomes:UP000005207}; RN [1] {ECO:0000313|Ensembl:ENSONIP00000007475} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. RN [2] {ECO:0000313|Proteomes:UP000005207} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=25186727; DOI=10.1038/nature13726; RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S., RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., RA Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., RA Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., RA Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O., RA Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R., RA Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T., RA Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S., RA Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D., RA Rakotomanga M., Renn S.C., Ribeiro F.J., Ron M., Salzburger W., RA Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R., RA Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D., RA Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A., RA Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O., RA Di Palma F.; RT "The genomic substrate for adaptive radiation in African cichlid RT fish."; RL Nature 513:375-381(2014). CC -!- FUNCTION: Mediates feedback control of cholesterol synthesis. CC {ECO:0000256|RuleBase:RU241113}. CC -!- SIMILARITY: Belongs to the INSIG family. CC {ECO:0000256|RuleBase:RU241113}. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation CC of feature annotation. {ECO:0000256|RuleBase:RU241113}. CC -!- CAUTION: The sequence shown here is derived from an Ensembl CC automatic analysis pipeline and should be considered as CC preliminary data. {ECO:0000313|Ensembl:ENSONIP00000007475}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AERX01002903; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_005448977.1; XM_005448920.2. DR STRING; 8128.ENSONIP00000007475; -. DR Ensembl; ENSONIT00000007480; ENSONIP00000007475; ENSONIG00000005939. DR GeneID; 100691598; -. DR CTD; 3638; -. DR eggNOG; KOG4363; Eukaryota. DR eggNOG; ENOG410XQ2M; LUCA. DR GeneTree; ENSGT00580000081600; -. DR InParanoid; I3JF34; -. DR OMA; EMMSIIT; -. DR OrthoDB; EOG7RNK13; -. DR TreeFam; TF331013; -. DR Proteomes; UP000005207; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW. DR GO; GO:0043087; P:regulation of GTPase activity; IEA:Ensembl. DR InterPro; IPR009904; INSIG-1. DR InterPro; IPR025929; INSIG_fam. DR PANTHER; PTHR15301:SF11; PTHR15301:SF11; 1. DR Pfam; PF07281; INSIG; 1. PE 3: Inferred from homology; KW Cholesterol metabolism {ECO:0000256|RuleBase:RU241113}; KW Complete proteome {ECO:0000313|Proteomes:UP000005207}; KW Lipid metabolism {ECO:0000256|RuleBase:RU241113}; KW Membrane {ECO:0000256|RuleBase:RU241113}; KW Reference proteome {ECO:0000313|Proteomes:UP000005207}; KW Steroid metabolism {ECO:0000256|RuleBase:RU241113}; KW Sterol metabolism {ECO:0000256|RuleBase:RU241113}; KW Transmembrane {ECO:0000256|RuleBase:RU241113}; KW Transmembrane helix {ECO:0000256|RuleBase:RU241113}. FT TRANSMEM 88 106 Helical. {ECO:0000256|RuleBase:RU241113}. FT TRANSMEM 126 146 Helical. {ECO:0000256|RuleBase:RU241113}. FT TRANSMEM 158 178 Helical. {ECO:0000256|RuleBase:RU241113}. FT TRANSMEM 184 203 Helical. {ECO:0000256|RuleBase:RU241113}. FT TRANSMEM 210 229 Helical. {ECO:0000256|RuleBase:RU241113}. FT TRANSMEM 241 262 Helical. {ECO:0000256|RuleBase:RU241113}. SQ SEQUENCE 276 AA; 30621 MW; 70398F796466DC4D CRC64; MNRRRGFCLE LTLKTSGDQA LKCQMPRLEE HCWSCSTSSK TETKHPSSGA NWLASRAEEM MSIITSVLSS AYISLHDVRT ANLIRRGVVL FTVGVFLALV LNLLQIQRNV TLFPEEVMTT LFSSAWWIPP CCGTGAAVIG LLYPCLDSHL GEPHKFKREW ASVMRCIAVF VGINHASVKL DFDNNVQLSL TLAALSLGLW WTFDRSRSGF GLGITTAFLA TVITQLLVYN GVYQYTSPDF LYVRSWLPCI FFSGGVTVGN IGRQLAMGGV EKPHMD //