ID I3JF34_ORENI Unreviewed; 276 AA. AC I3JF34; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 11-JUL-2012, sequence version 1. DT 27-MAY-2015, entry version 18. DE RecName: Full=Insulin-induced gene protein {ECO:0000256|RuleBase:RU241113}; GN Name=LOC100691598 {ECO:0000313|Ensembl:ENSONIP00000007475}; OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids; OC Pseudocrenilabrinae; Oreochromini; Oreochromis. OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000007475, ECO:0000313|Proteomes:UP000005207}; RN [1] {ECO:0000313|Ensembl:ENSONIP00000007475} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG Broad Institute Genome Assembly Team; RG Broad Institute Sequencing Platform; RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.; RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia)."; RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSONIP00000007475} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. CC -!- FUNCTION: Mediates feedback control of cholesterol synthesis. CC {ECO:0000256|RuleBase:RU241113}. CC -!- SIMILARITY: Belongs to the INSIG family. CC {ECO:0000256|RuleBase:RU241113}. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation CC of feature annotation. {ECO:0000256|RuleBase:RU241113}. CC -!- CAUTION: The sequence shown here is derived from an Ensembl CC automatic analysis pipeline and should be considered as CC preliminary data. {ECO:0000313|Ensembl:ENSONIP00000007475}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AERX01002903; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_005448977.1; XM_005448920.1. DR Ensembl; ENSONIT00000007480; ENSONIP00000007475; ENSONIG00000005939. DR GeneID; 100691598; -. DR GeneTree; ENSGT00580000081600; -. DR InParanoid; I3JF34; -. DR OMA; EMMSIIT; -. DR OrthoDB; EOG7RNK13; -. DR TreeFam; TF331013; -. DR Proteomes; UP000005207; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW. DR InterPro; IPR009904; INSIG-1. DR InterPro; IPR025929; INSIG_fam. DR PANTHER; PTHR15301:SF11; PTHR15301:SF11; 1. DR Pfam; PF07281; INSIG; 1. PE 3: Inferred from homology; KW Cholesterol metabolism {ECO:0000256|RuleBase:RU241113}; KW Complete proteome {ECO:0000313|Proteomes:UP000005207}; KW Lipid metabolism {ECO:0000256|RuleBase:RU241113}; KW Membrane {ECO:0000256|RuleBase:RU241113}; KW Reference proteome {ECO:0000313|Proteomes:UP000005207}; KW Steroid metabolism {ECO:0000256|RuleBase:RU241113}; KW Sterol metabolism {ECO:0000256|RuleBase:RU241113}; KW Transmembrane {ECO:0000256|RuleBase:RU241113}; KW Transmembrane helix {ECO:0000256|RuleBase:RU241113}. FT TRANSMEM 88 106 Helical. {ECO:0000256|RuleBase:RU241113}. FT TRANSMEM 126 146 Helical. {ECO:0000256|RuleBase:RU241113}. FT TRANSMEM 158 178 Helical. {ECO:0000256|RuleBase:RU241113}. FT TRANSMEM 184 203 Helical. {ECO:0000256|RuleBase:RU241113}. FT TRANSMEM 210 229 Helical. {ECO:0000256|RuleBase:RU241113}. FT TRANSMEM 241 262 Helical. {ECO:0000256|RuleBase:RU241113}. SQ SEQUENCE 276 AA; 30621 MW; 70398F796466DC4D CRC64; MNRRRGFCLE LTLKTSGDQA LKCQMPRLEE HCWSCSTSSK TETKHPSSGA NWLASRAEEM MSIITSVLSS AYISLHDVRT ANLIRRGVVL FTVGVFLALV LNLLQIQRNV TLFPEEVMTT LFSSAWWIPP CCGTGAAVIG LLYPCLDSHL GEPHKFKREW ASVMRCIAVF VGINHASVKL DFDNNVQLSL TLAALSLGLW WTFDRSRSGF GLGITTAFLA TVITQLLVYN GVYQYTSPDF LYVRSWLPCI FFSGGVTVGN IGRQLAMGGV EKPHMD //