ID I2IMD5_9BURK Unreviewed; 563 AA. AC I2IMD5; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 11-JUL-2012, sequence version 1. DT 14-DEC-2022, entry version 42. DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551}; DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551}; GN ORFNames=BCh11DRAFT_07437 {ECO:0000313|EMBL:EIF31887.1}; OS Burkholderia sp. Ch1-1. OC Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales; OC Burkholderiaceae; Burkholderia. OX NCBI_TaxID=243261 {ECO:0000313|EMBL:EIF31887.1}; RN [1] {ECO:0000313|EMBL:EIF31887.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Ch1-1 {ECO:0000313|EMBL:EIF31887.1}; RG US DOE Joint Genome Institute; RA Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., RA Peters L., Ovchinnikova G., Teshima H., Detter J.C., Han C., Tapia R., RA Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Bradfield C., RA Sheety A., Cheng S., Chain P., Denef V., Hickey W., Woyke T.; RT "Improved High-Quality Draft sequence of Burkholderia sp. Ch1-1."; RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12; CC Evidence={ECO:0000256|ARBA:ARBA00001665}; CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily. CC {ECO:0000256|ARBA:ARBA00009922}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; JH603161; EIF31887.1; -; Genomic_DNA. DR RefSeq; WP_007182579.1; NZ_JH603161.1. DR AlphaFoldDB; I2IMD5; -. DR EnsemblBacteria; EIF31887; EIF31887; BCh11DRAFT_07437. DR HOGENOM; CLU_004585_5_10_4; -. DR Proteomes; UP000005779; Unassembled WGS sequence. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule. DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA. DR GO; GO:0003677; F:DNA binding; IEA:InterPro. DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro. DR Gene3D; 1.10.10.160; -; 1. DR Gene3D; 3.40.50.300; -; 2. DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf. DR InterPro; IPR014017; DNA_helicase_UvrD-like_C. DR InterPro; IPR000212; DNA_helicase_UvrD/REP. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR014016; UvrD-like_ATP-bd. DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1. DR Pfam; PF13361; UvrD_C; 2. DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1. DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1. DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1. PE 3: Inferred from homology; KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE- KW ProRule:PRU00560}; DNA-binding {ECO:0000256|ARBA:ARBA00023125}; KW Helicase {ECO:0000256|PROSITE-ProRule:PRU00560, KW ECO:0000313|EMBL:EIF31887.1}; KW Hydrolase {ECO:0000256|PROSITE-ProRule:PRU00560}; KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE- KW ProRule:PRU00560}. FT DOMAIN 2..253 FT /note="UvrD-like helicase ATP-binding" FT /evidence="ECO:0000259|PROSITE:PS51198" FT DOMAIN 254..502 FT /note="UvrD-like helicase C-terminal" FT /evidence="ECO:0000259|PROSITE:PS51217" FT BINDING 23..30 FT /ligand="ATP" FT /ligand_id="ChEBI:CHEBI:30616" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560" SQ SEQUENCE 563 AA; 61727 MW; 8C523CBDA1B070CC CRC64; MLDGLNPKQR EVAELRRPCV AIACPGAGKT KTIAAKAALL LGDPHTVVGA VTFSKDAAVE LRDRILALAG AGAKSRLIAG TFHSLANRQL GKRDIATDGD RAGLIARVLA ELGLQWKTEE VIPVIERIKT NFGRVEDGGP DAQLYHAYQE ALARNGKIDF QDMLRLAVAG MEAGDIEPYR FTDLLVDEFQ DTDPLQYRWV ELHADAGARV TVVGDDDQSI YGFRAALGFR GMESFAASFN AQRIVLGSNY RCRSEILAAA DRVIRNNVDR IAKVLHAERG AGGAIATRRF DDEYSDAVAA VEQLQPLLAA GNSCAILART NRILDPIEAV CRSHGVPYYR ASGASVLNGP QGALMCNLLQ IAEGRKQNGL DAVLGYTGMS STHLGALHRD MGAVLIQRAK KDLVALGLSD DTASAYRAFM KRLAEWTQMC ERRFYALALD GVLEMMMTYA RDDRAKRAIQ ATYDVLSRLN GTFAERIEYL KRDNNKPADG ALVLTTMHSS KGLEWNHVWI TRAEEGIVPD EKSTESEERR LFYVAMTRAR DTLTIATIKK NPVSRFVIES AIA //