ID I2A567_9HIV1 Unreviewed; 201 AA. AC I2A567; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 11-JUL-2012, sequence version 1. DT 02-OCT-2024, entry version 47. DE RecName: Full=Protein Nef {ECO:0000256|ARBA:ARBA00013526, ECO:0000256|RuleBase:RU000344}; DE Flags: Fragment; GN Name=nef {ECO:0000313|EMBL:AFJ32441.1}; OS Human immunodeficiency virus 1. OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes; OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus. OX NCBI_TaxID=11676 {ECO:0000313|EMBL:AFJ32441.1}; OH NCBI_TaxID=9606; Homo sapiens (Human). RN [1] {ECO:0000313|EMBL:AFJ32441.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=39_Control_clone18 {ECO:0000313|EMBL:AFJ32441.1}; RX PubMed=22553319; DOI=10.1128/JVI.00878-12; RA Lewis M.J., Lee P., Ng H.L., Yang O.O.; RT "Immune selection in vitro reveals human immunodeficiency virus type 1 nef RT sequence motifs important for its immune evasion function in vivo."; RL J. Virol. 86:7126-7135(2012). CC -!- SIMILARITY: Belongs to the lentivirus primate group Nef protein family. CC {ECO:0000256|ARBA:ARBA00006933, ECO:0000256|RuleBase:RU000344}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; JQ928006; AFJ32441.1; -; Genomic_RNA. DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-KW. DR GO; GO:0005525; F:GTP binding; IEA:InterPro. DR GO; GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW. DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW. DR GO; GO:0019049; P:virus-mediated perturbation of host defense response; IEA:UniProtKB-KW. DR Gene3D; 4.10.890.10; HIV 1 nef anchor domain; 1. DR Gene3D; 3.30.62.10; Nef Regulatory Factor; 1. DR InterPro; IPR027480; HIV-1_Nef_anchor_sf. DR InterPro; IPR027481; HIV-1_Nef_core_sf. DR InterPro; IPR001558; HIV_Nef. DR Pfam; PF00469; F-protein; 1. DR SUPFAM; SSF55671; Regulatory factor Nef; 1. PE 3: Inferred from homology; KW Apoptosis {ECO:0000256|ARBA:ARBA00022703}; KW Host cell membrane {ECO:0000256|ARBA:ARBA00022511}; KW Host membrane {ECO:0000256|ARBA:ARBA00022870}; KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581}; KW Lipoprotein {ECO:0000256|RuleBase:RU000344}; KW Membrane {ECO:0000256|ARBA:ARBA00022870}; KW Myristate {ECO:0000256|ARBA:ARBA00022707, ECO:0000256|RuleBase:RU000344}; KW SH3-binding {ECO:0000256|ARBA:ARBA00023036}; KW Viral immunoevasion {ECO:0000256|RuleBase:RU000344}; KW Virulence {ECO:0000256|ARBA:ARBA00023026, ECO:0000256|RuleBase:RU000344}. FT NON_TER 201 FT /evidence="ECO:0000313|EMBL:AFJ32441.1" SQ SEQUENCE 201 AA; 22563 MW; 5132FF7E9B8A65FA CRC64; MGGKGSKWGV PGWXAIRERM RRTEPAAEGV GAVSRDLENH GAITSSDTAA TNAACARLEA QEGEEVGFPV RPQVPLRPMD YKGAVDLSHF LKDKGGLEGM ICSQKRQDIL DLWIYHTQGY FPDWQNYTPG PGTRFPLTFG WCFKLVPVEP EDGGENTNLL HPVSQHGMDD LEKEVLQWKF DSKLAFHHVA RELHPEYFKN C //