ID I2A527_9HIV1 Unreviewed; 205 AA. AC I2A527; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 11-JUL-2012, sequence version 1. DT 16-OCT-2013, entry version 9. DE RecName: Full=Protein Nef; DE Flags: Fragment; GN Name=nef; OS Human immunodeficiency virus 1. OC Viruses; Retro-transcribing viruses; Retroviridae; Orthoretrovirinae; OC Lentivirus; Primate lentivirus group. OX NCBI_TaxID=11676; OH NCBI_TaxID=9606; Homo sapiens (Human). RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=26_Control_clone14; RX PubMed=22553319; DOI=10.1128/JVI.00878-12; RA Lewis M.J., Lee P., Ng H.L., Yang O.O.; RT "Immune selection in vitro reveals human immunodeficiency virus type 1 RT nef sequence motifs important for its immune evasion function in RT vivo."; RL J. Virol. 86:7126-7135(2012). CC -!- SIMILARITY: Belongs to the lentivirus primate group Nef protein CC family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; JQ927961; AFJ32401.1; -; Genomic_RNA. DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-KW. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW. DR GO; GO:0005525; F:GTP binding; IEA:InterPro. DR GO; GO:0030683; P:evasion or tolerance by virus of host immune response; IEA:UniProtKB-KW. DR GO; GO:0009405; P:pathogenesis; IEA:UniProtKB-KW. DR Gene3D; 3.30.62.10; -; 1. DR Gene3D; 4.10.890.10; -; 1. DR InterPro; IPR027480; HIV-1_Nef_anchor. DR InterPro; IPR027481; HIV-1_Nef_core. DR InterPro; IPR001558; HIV_Nef. DR Pfam; PF00469; F-protein; 1. DR SUPFAM; SSF55671; SSF55671; 1. PE 3: Inferred from homology; KW Host cell membrane; Host membrane; Host-virus interaction; KW Lipoprotein; Membrane; Myristate; Viral immunoevasion; Virulence. FT NON_TER 205 205 SQ SEQUENCE 205 AA; 23550 MW; EECB3331E89994AA CRC64; MGXKWSKRXV GWPTXRERRR RAXPAPEGVG AASRDLEKYG AITSSNTAAT NADCAWLEAQ EEEEVGFPVR PQVPLRPMTY KAAIDLSHFL KEKGGLEGLI YSQKRQDILD LWIHHTQGYF PDWQNYTPGP GVRYPLTFGW CFKLVPVDPD KVEEANEGEN NVLLHPMSQH GMDDPEKEVL MWKFDSRLAF HHVARELHPE YFKNC //