ID I2A527_9HIV1 Unreviewed; 205 AA. AC I2A527; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 11-JUL-2012, sequence version 1. DT 26-NOV-2014, entry version 12. DE RecName: Full=Protein Nef {ECO:0000256|RuleBase:RU000344, ECO:0000256|SAAS:SAAS00118351}; DE Flags: Fragment; GN Name=nef {ECO:0000313|EMBL:AFJ32401.1}; OS Human immunodeficiency virus 1. OC Viruses; Retro-transcribing viruses; Retroviridae; Orthoretrovirinae; OC Lentivirus; Primate lentivirus group. OX NCBI_TaxID=11676 {ECO:0000313|EMBL:AFJ32401.1}; OH NCBI_TaxID=9606; Homo sapiens (Human). RN [1] {ECO:0000313|EMBL:AFJ32401.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=26_Control_clone14 {ECO:0000313|EMBL:AFJ32401.1}; RX PubMed=22553319; DOI=10.1128/JVI.00878-12; RA Lewis M.J., Lee P., Ng H.L., Yang O.O.; RT "Immune selection in vitro reveals human immunodeficiency virus type 1 RT nef sequence motifs important for its immune evasion function in RT vivo."; RL J. Virol. 86:7126-7135(2012). CC -!- SIMILARITY: Belongs to the lentivirus primate group Nef protein CC family. {ECO:0000256|RuleBase:RU000344}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; JQ927961; AFJ32401.1; -; Genomic_RNA. DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-KW. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW. DR GO; GO:0005525; F:GTP binding; IEA:InterPro. DR GO; GO:0030683; P:evasion or tolerance by virus of host immune response; IEA:UniProtKB-KW. DR GO; GO:0009405; P:pathogenesis; IEA:UniProtKB-KW. DR Gene3D; 3.30.62.10; -; 1. DR Gene3D; 4.10.890.10; -; 1. DR InterPro; IPR027480; HIV-1_Nef_anchor. DR InterPro; IPR027481; HIV-1_Nef_core. DR InterPro; IPR001558; HIV_Nef. DR Pfam; PF00469; F-protein; 1. DR SUPFAM; SSF55671; SSF55671; 1. PE 3: Inferred from homology; KW Host cell membrane {ECO:0000256|SAAS:SAAS00118340}; KW Host membrane {ECO:0000256|SAAS:SAAS00118235}; KW Host-virus interaction {ECO:0000256|SAAS:SAAS00118336}; KW Lipoprotein {ECO:0000256|RuleBase:RU003609}; KW Membrane {ECO:0000256|SAAS:SAAS00118205}; KW Myristate {ECO:0000256|RuleBase:RU003609}; KW Viral immunoevasion {ECO:0000256|RuleBase:RU000344}; KW Virulence {ECO:0000256|RuleBase:RU000344}. FT NON_TER 205 205 {ECO:0000313|EMBL:AFJ32401.1}. SQ SEQUENCE 205 AA; 23550 MW; EECB3331E89994AA CRC64; MGXKWSKRXV GWPTXRERRR RAXPAPEGVG AASRDLEKYG AITSSNTAAT NADCAWLEAQ EEEEVGFPVR PQVPLRPMTY KAAIDLSHFL KEKGGLEGLI YSQKRQDILD LWIHHTQGYF PDWQNYTPGP GVRYPLTFGW CFKLVPVDPD KVEEANEGEN NVLLHPMSQH GMDDPEKEVL MWKFDSRLAF HHVARELHPE YFKNC //