ID I1YN96_CHAHI Unreviewed; 323 AA. AC I1YN96; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 11-JUL-2012, sequence version 1. DT 13-FEB-2019, entry version 26. DE RecName: Full=NADH-ubiquinone oxidoreductase chain 2 {ECO:0000256|RuleBase:RU003403, ECO:0000256|SAAS:SAAS00387861}; DE EC=7.1.1.2 {ECO:0000256|RuleBase:RU003403, ECO:0000256|SAAS:SAAS01109717}; DE Flags: Fragment; GN Name=ND2 {ECO:0000313|EMBL:AFJ06483.1}; OS Chaetodipus hispidus (Hispid pocket mouse) (Perognathus hispidus). OG Mitochondrion {ECO:0000313|EMBL:AFJ06483.1}. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Castorimorpha; OC Heteromyidae; Perognathinae; Chaetodipus. OX NCBI_TaxID=38665 {ECO:0000313|EMBL:AFJ06483.1}; RN [1] {ECO:0000313|EMBL:AFJ06483.1} RP NUCLEOTIDE SEQUENCE. RA Andersen J.J., Light J.E.; RT "Phylogeography and subspecies revision of the hispid pocket mouse, RT Chaetodipus hispidus (Rodentia: Heteromyidae)."; RL J. Mammal. 93:1195-1215(2012). CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory CC chain NADH dehydrogenase (Complex I) that is believed to belong to CC the minimal assembly required for catalysis. Complex I functions CC in the transfer of electrons from NADH to the respiratory chain. CC The immediate electron acceptor for the enzyme is believed to be CC ubiquinone. {ECO:0000256|RuleBase:RU003403, CC ECO:0000256|SAAS:SAAS00093760}. CC -!- CATALYTIC ACTIVITY: CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 CC H(+)(out) + NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, CC Rhea:RHEA-COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, CC ChEBI:CHEBI:17976, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; CC EC=7.1.1.2; Evidence={ECO:0000256|RuleBase:RU003403, CC ECO:0000256|SAAS:SAAS01125045}; CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane CC {ECO:0000256|RuleBase:RU003403, ECO:0000256|SAAS:SAAS00093751}; CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU003403, CC ECO:0000256|SAAS:SAAS00093751}. CC -!- SIMILARITY: Belongs to the complex I subunit 2 family. CC {ECO:0000256|RuleBase:RU003403, ECO:0000256|SAAS:SAAS00573211}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; JQ411917; AFJ06483.1; -; Genomic_DNA. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell. DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW. DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:InterPro. DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; IEA:InterPro. DR InterPro; IPR010933; NADH_DH_su2_C. DR InterPro; IPR003917; NADH_UbQ_OxRdtase_chain2. DR InterPro; IPR001750; ND/Mrp_mem. DR Pfam; PF06444; NADH_dehy_S2_C; 1. DR Pfam; PF00361; Proton_antipo_M; 1. DR PRINTS; PR01436; NADHDHGNASE2. PE 3: Inferred from homology; KW Electron transport {ECO:0000256|RuleBase:RU003403, KW ECO:0000256|SAAS:SAAS00464461}; KW Membrane {ECO:0000256|RuleBase:RU003403, KW ECO:0000256|SAAS:SAAS00093718}; KW Mitochondrion {ECO:0000256|RuleBase:RU003403, KW ECO:0000256|SAAS:SAAS00464403, ECO:0000313|EMBL:AFJ06483.1}; KW Mitochondrion inner membrane {ECO:0000256|RuleBase:RU003403, KW ECO:0000256|SAAS:SAAS00464436}; KW NAD {ECO:0000256|RuleBase:RU003403, ECO:0000256|SAAS:SAAS00093707}; KW Respiratory chain {ECO:0000256|RuleBase:RU003403, KW ECO:0000256|SAAS:SAAS00093685}; KW Translocase {ECO:0000256|RuleBase:RU003403, KW ECO:0000256|SAAS:SAAS01109684}; KW Transmembrane {ECO:0000256|RuleBase:RU003403, KW ECO:0000256|SAAS:SAAS00093696}; KW Transmembrane helix {ECO:0000256|RuleBase:RU003403, KW ECO:0000256|SAAS:SAAS00464584}; KW Transport {ECO:0000256|SAAS:SAAS00093687}; KW Ubiquinone {ECO:0000256|RuleBase:RU003403, KW ECO:0000256|SAAS:SAAS00093675}. FT TRANSMEM 14 34 Helical. {ECO:0000256|RuleBase:RU003403}. FT TRANSMEM 46 63 Helical. {ECO:0000256|RuleBase:RU003403}. FT TRANSMEM 83 102 Helical. {ECO:0000256|RuleBase:RU003403}. FT TRANSMEM 139 158 Helical. {ECO:0000256|RuleBase:RU003403}. FT TRANSMEM 189 209 Helical. {ECO:0000256|RuleBase:RU003403}. FT TRANSMEM 221 241 Helical. {ECO:0000256|RuleBase:RU003403}. FT TRANSMEM 261 281 Helical. {ECO:0000256|RuleBase:RU003403}. FT DOMAIN 10 273 Proton_antipo_M. {ECO:0000259|Pfam: FT PF00361}. FT DOMAIN 277 322 NADH_dehy_S2_C. {ECO:0000259|Pfam: FT PF06444}. FT NON_TER 1 1 {ECO:0000313|EMBL:AFJ06483.1}. FT NON_TER 323 323 {ECO:0000313|EMBL:AFJ06483.1}. SQ SEQUENCE 323 AA; 36309 MW; BE62BC4D0B42734C CRC64; ITGTTLVLIA SHWMFMWVGL ELSMLAMIPL MTYSNNPRST EAATKYFLTQ ATASMILLLA ILNNTSNSGQ WNIIQPEDML SQYLFLVALG MKLGLAPFHF WVPEVTQGIP IKSGLILLTW QKLAPISIMY QLSPYLNKNM MITMALMSIL MGGWGGLNQM QTRKIMAYSS IAHMGWMSAI VTYNPPMMML NLFIYIALTM TMFLALNHLS AKSTSTLSMA WNTNATLTSI LLITLMSLGG LPPLTGFLPK WVIIQELISN HNILVSLIMA MAALLNLYFY LRLTYNSALT LFPTPNNMKF SWRMNKQKSV WPISPLLMMS CMS //