ID I1WZP5_CAPHI Unreviewed; 276 AA. AC I1WZP5; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 11-JUL-2012, sequence version 1. DT 08-NOV-2023, entry version 45. DE RecName: Full=Insulin-induced gene protein {ECO:0000256|RuleBase:RU241113}; GN Name=INSIG1 {ECO:0000313|EMBL:AFI72778.1, GN ECO:0000313|Ensembl:ENSCHIP00000027373.1}; OS Capra hircus (Goat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; OC Caprinae; Capra. OX NCBI_TaxID=9925 {ECO:0000313|EMBL:AFI72778.1}; RN [1] {ECO:0000313|EMBL:AFI72778.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Mammary gland {ECO:0000313|EMBL:AFI72778.1}; RA Wang H., Hu L., Luo J.; RT "Clone and Structural Analysis of Goat INSIG1 and Construction of RNA RT Interfering Adenovirus Vectors."; RL Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSCHIP00000027373.1, ECO:0000313|Proteomes:UP000291000} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T., RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M., RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A., RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S., RA Phillippy A.M., Van Tassell C.P., Smith T.P.; RT "Polished mammalian reference genomes with single-molecule sequencing and RT chromosome conformation capture applied to the Capra hircus genome."; RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSCHIP00000027373.1} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2023) to UniProtKB. CC -!- FUNCTION: Mediates feedback control of cholesterol synthesis. CC {ECO:0000256|RuleBase:RU241113}. CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane CC {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU241113}; Multi- CC pass membrane protein {ECO:0000256|ARBA:ARBA00004477, CC ECO:0000256|RuleBase:RU241113}. Membrane CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004141}. CC -!- SIMILARITY: Belongs to the INSIG family. CC {ECO:0000256|ARBA:ARBA00007475, ECO:0000256|RuleBase:RU241113}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; LWLT01000003; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; JQ665439; AFI72778.1; -; mRNA. DR RefSeq; NP_001273017.1; NM_001286088.1. DR Ensembl; ENSCHIT00000035241.1; ENSCHIP00000027373.1; ENSCHIG00000023323.1. DR Ensembl; ENSCHIT00000035248.1; ENSCHIP00000027380.1; ENSCHIG00000023323.1. DR GeneID; 102183937; -. DR KEGG; chx:102183937; -. DR CTD; 3638; -. DR GeneTree; ENSGT00580000081600; -. DR OrthoDB; 2943928at2759; -. DR Proteomes; UP000291000; Chromosome 4. DR Bgee; ENSCHIG00000023323; Expressed in adrenal gland and 17 other tissues. DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. DR GO; GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW. DR InterPro; IPR025929; INSIG_fam. DR PANTHER; PTHR15301; INSULIN-INDUCED GENE 1; 1. DR PANTHER; PTHR15301:SF11; INSULIN-INDUCED GENE 1 PROTEIN; 1. DR Pfam; PF07281; INSIG; 1. PE 2: Evidence at transcript level; KW Cholesterol metabolism {ECO:0000256|ARBA:ARBA00022548, KW ECO:0000256|RuleBase:RU241113}; KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824, KW ECO:0000256|RuleBase:RU241113}; KW Lipid metabolism {ECO:0000256|RuleBase:RU241113}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU241113}; KW Reference proteome {ECO:0000313|Proteomes:UP000291000}; KW Steroid metabolism {ECO:0000256|ARBA:ARBA00023221, KW ECO:0000256|RuleBase:RU241113}; KW Sterol metabolism {ECO:0000256|ARBA:ARBA00023166}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, KW ECO:0000256|RuleBase:RU241113}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|RuleBase:RU241113}. FT TRANSMEM 88..106 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU241113" FT TRANSMEM 126..146 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU241113" FT TRANSMEM 182..203 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU241113" FT TRANSMEM 210..229 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU241113" FT TRANSMEM 241..262 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU241113" FT REGION 1..26 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 45..71 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 276 AA; 29696 MW; 11BEEA383CA72B2C CRC64; MPRLDDHLWR GPCAKGTKHR SHPRASARGL VAKAGEMINS SGSGPSLLAA HGAPGTDPTH GLQSTDVGGQ GSSGHVNSWH HHLVQRSLVL FSVGVVLALV LNLLQVQRNV TLFPDEVIAT IFSSAWWVPP CCGTAAAVVG LLYPCIDSHL GEPHKFKREW ASVMRCVAVF VGINHASAKL DFANNVQLSL TLAALSLGLW WTFDRSRSGL GLGITIAFLA TLITQLLVYN GVYQYTSPDF LYIRSWLPCI FFSGGVTVGN IGRQLAMGVP EKPHSD //