ID   I1WZP5_CAPHI            Unreviewed;       276 AA.
AC   I1WZP5;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   13-SEP-2023, entry version 44.
DE   RecName: Full=Insulin-induced gene protein {ECO:0000256|RuleBase:RU241113};
GN   Name=INSIG1 {ECO:0000313|EMBL:AFI72778.1,
GN   ECO:0000313|Ensembl:ENSCHIP00000027373.1};
OS   Capra hircus (Goat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Capra.
OX   NCBI_TaxID=9925 {ECO:0000313|EMBL:AFI72778.1};
RN   [1] {ECO:0000313|EMBL:AFI72778.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Mammary gland {ECO:0000313|EMBL:AFI72778.1};
RA   Wang H., Hu L., Luo J.;
RT   "Clone and Structural Analysis of Goat INSIG1 and Construction of RNA
RT   Interfering Adenovirus Vectors.";
RL   Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCHIP00000027373.1, ECO:0000313|Proteomes:UP000291000}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA   Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA   Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA   Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA   Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT   "Polished mammalian reference genomes with single-molecule sequencing and
RT   chromosome conformation capture applied to the Capra hircus genome.";
RL   Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSCHIP00000027373.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2023) to UniProtKB.
CC   -!- FUNCTION: Mediates feedback control of cholesterol synthesis.
CC       {ECO:0000256|RuleBase:RU241113}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU241113}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004477,
CC       ECO:0000256|RuleBase:RU241113}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the INSIG family.
CC       {ECO:0000256|ARBA:ARBA00007475, ECO:0000256|RuleBase:RU241113}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; LWLT01000003; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JQ665439; AFI72778.1; -; mRNA.
DR   RefSeq; NP_001273017.1; NM_001286088.1.
DR   Ensembl; ENSCHIT00000035241.1; ENSCHIP00000027373.1; ENSCHIG00000023323.1.
DR   Ensembl; ENSCHIT00000035248.1; ENSCHIP00000027380.1; ENSCHIG00000023323.1.
DR   GeneID; 102183937; -.
DR   KEGG; chx:102183937; -.
DR   CTD; 3638; -.
DR   GeneTree; ENSGT00580000081600; -.
DR   OrthoDB; 2943928at2759; -.
DR   Proteomes; UP000291000; Chromosome 4.
DR   Bgee; ENSCHIG00000023323; Expressed in adrenal gland and 17 other tissues.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.
DR   InterPro; IPR025929; INSIG_fam.
DR   PANTHER; PTHR15301; INSULIN-INDUCED GENE 1; 1.
DR   PANTHER; PTHR15301:SF11; INSULIN-INDUCED GENE 1 PROTEIN; 1.
DR   Pfam; PF07281; INSIG; 1.
PE   2: Evidence at transcript level;
KW   Cholesterol metabolism {ECO:0000256|ARBA:ARBA00022548,
KW   ECO:0000256|RuleBase:RU241113};
KW   Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824,
KW   ECO:0000256|RuleBase:RU241113};
KW   Lipid metabolism {ECO:0000256|RuleBase:RU241113};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU241113};
KW   Reference proteome {ECO:0000313|Proteomes:UP000291000};
KW   Steroid metabolism {ECO:0000256|ARBA:ARBA00023221,
KW   ECO:0000256|RuleBase:RU241113};
KW   Sterol metabolism {ECO:0000256|ARBA:ARBA00023166};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU241113};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU241113}.
FT   TRANSMEM        88..106
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU241113"
FT   TRANSMEM        126..146
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU241113"
FT   TRANSMEM        182..203
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU241113"
FT   TRANSMEM        210..229
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU241113"
FT   TRANSMEM        241..262
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU241113"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          45..71
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   276 AA;  29696 MW;  11BEEA383CA72B2C CRC64;
     MPRLDDHLWR GPCAKGTKHR SHPRASARGL VAKAGEMINS SGSGPSLLAA HGAPGTDPTH
     GLQSTDVGGQ GSSGHVNSWH HHLVQRSLVL FSVGVVLALV LNLLQVQRNV TLFPDEVIAT
     IFSSAWWVPP CCGTAAAVVG LLYPCIDSHL GEPHKFKREW ASVMRCVAVF VGINHASAKL
     DFANNVQLSL TLAALSLGLW WTFDRSRSGL GLGITIAFLA TLITQLLVYN GVYQYTSPDF
     LYIRSWLPCI FFSGGVTVGN IGRQLAMGVP EKPHSD
//