ID I1WZP5_CAPHI Unreviewed; 276 AA. AC I1WZP5; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 11-JUL-2012, sequence version 1. DT 08-MAY-2019, entry version 28. DE RecName: Full=Insulin-induced gene protein {ECO:0000256|RuleBase:RU241113}; GN Name=INSIG1 {ECO:0000313|EMBL:AFI72778.1, GN ECO:0000313|Ensembl:ENSCHIP00000027373}; OS Capra hircus (Goat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Caprinae; Capra. OX NCBI_TaxID=9925 {ECO:0000313|EMBL:AFI72778.1}; RN [1] {ECO:0000313|EMBL:AFI72778.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Mammary gland {ECO:0000313|EMBL:AFI72778.1}; RA Wang H., Hu L., Luo J.; RT "Clone and Structural Analysis of Goat INSIG1 and Construction of RNA RT Interfering Adenovirus Vectors."; RL Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSCHIP00000027373, ECO:0000313|Proteomes:UP000291000} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., RA Sullivan S.T., Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., RA Kelley C.M., Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., RA Hammond J.A., Schroeder S.G., Liu G.E., Dunham M., Shendure J., RA Sonstegard T.S., Phillippy A.M., Van Tassell C.P., Smith T.P.; RT "Polished mammalian reference genomes with single-molecule sequencing RT and chromosome conformation capture applied to the Capra hircus RT genome."; RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSCHIP00000027373} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2019) to UniProtKB. CC -!- FUNCTION: Mediates feedback control of cholesterol synthesis. CC {ECO:0000256|RuleBase:RU241113}. CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane CC {ECO:0000256|RuleBase:RU241113}; Multi-pass membrane protein CC {ECO:0000256|RuleBase:RU241113}. CC -!- SIMILARITY: Belongs to the INSIG family. CC {ECO:0000256|RuleBase:RU241113}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; LWLT01000003; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; JQ665439; AFI72778.1; -; mRNA. DR RefSeq; NP_001273017.1; NM_001286088.1. DR Ensembl; ENSCHIT00000035241; ENSCHIP00000027373; ENSCHIG00000023323. DR Ensembl; ENSCHIT00000035248; ENSCHIP00000027380; ENSCHIG00000023323. DR GeneID; 102183937; -. DR KEGG; chx:102183937; -. DR CTD; 3638; -. DR GeneTree; ENSGT00580000081600; -. DR OrthoDB; 1342554at2759; -. DR Proteomes; UP000291000; Chromosome 4. DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW. DR InterPro; IPR009904; INSIG-1. DR InterPro; IPR025929; INSIG_fam. DR PANTHER; PTHR15301; PTHR15301; 1. DR PANTHER; PTHR15301:SF11; PTHR15301:SF11; 1. DR Pfam; PF07281; INSIG; 1. PE 2: Evidence at transcript level; KW Cholesterol metabolism {ECO:0000256|RuleBase:RU241113}; KW Complete proteome {ECO:0000313|Proteomes:UP000291000}; KW Endoplasmic reticulum {ECO:0000256|RuleBase:RU241113}; KW Lipid metabolism {ECO:0000256|RuleBase:RU241113}; KW Membrane {ECO:0000256|RuleBase:RU241113}; KW Steroid metabolism {ECO:0000256|RuleBase:RU241113}; KW Sterol metabolism {ECO:0000256|RuleBase:RU241113}; KW Transmembrane {ECO:0000256|RuleBase:RU241113}; KW Transmembrane helix {ECO:0000256|RuleBase:RU241113}. FT TRANSMEM 88 106 Helical. {ECO:0000256|RuleBase:RU241113}. FT TRANSMEM 126 146 Helical. {ECO:0000256|RuleBase:RU241113}. FT TRANSMEM 182 203 Helical. {ECO:0000256|RuleBase:RU241113}. FT TRANSMEM 210 229 Helical. {ECO:0000256|RuleBase:RU241113}. FT TRANSMEM 241 262 Helical. {ECO:0000256|RuleBase:RU241113}. SQ SEQUENCE 276 AA; 29696 MW; 11BEEA383CA72B2C CRC64; MPRLDDHLWR GPCAKGTKHR SHPRASARGL VAKAGEMINS SGSGPSLLAA HGAPGTDPTH GLQSTDVGGQ GSSGHVNSWH HHLVQRSLVL FSVGVVLALV LNLLQVQRNV TLFPDEVIAT IFSSAWWVPP CCGTAAAVVG LLYPCIDSHL GEPHKFKREW ASVMRCVAVF VGINHASAKL DFANNVQLSL TLAALSLGLW WTFDRSRSGL GLGITIAFLA TLITQLLVYN GVYQYTSPDF LYIRSWLPCI FFSGGVTVGN IGRQLAMGVP EKPHSD //