ID   I1WZP5_CAPHI            Unreviewed;       276 AA.
AC   I1WZP5;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   16-JAN-2019, entry version 27.
DE   RecName: Full=Insulin-induced gene protein {ECO:0000256|RuleBase:RU241113};
GN   Name=INSIG1 {ECO:0000313|EMBL:AFI72778.1};
OS   Capra hircus (Goat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Caprinae; Capra.
OX   NCBI_TaxID=9925 {ECO:0000313|EMBL:AFI72778.1};
RN   [1] {ECO:0000313|EMBL:AFI72778.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Mammary gland {ECO:0000313|EMBL:AFI72778.1};
RA   Wang H., Hu L., Luo J.;
RT   "Clone and Structural Analysis of Goat INSIG1 and Construction of RNA
RT   Interfering Adenovirus Vectors.";
RL   Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mediates feedback control of cholesterol synthesis.
CC       {ECO:0000256|RuleBase:RU241113}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|RuleBase:RU241113}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU241113}.
CC   -!- SIMILARITY: Belongs to the INSIG family.
CC       {ECO:0000256|RuleBase:RU241113}.
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DR   EMBL; JQ665439; AFI72778.1; -; mRNA.
DR   RefSeq; NP_001273017.1; NM_001286088.1.
DR   UniGene; Chi.15201; -.
DR   GeneID; 102183937; -.
DR   KEGG; chx:102183937; -.
DR   CTD; 3638; -.
DR   OrthoDB; 1342554at2759; -.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.
DR   InterPro; IPR009904; INSIG-1.
DR   InterPro; IPR025929; INSIG_fam.
DR   PANTHER; PTHR15301; PTHR15301; 1.
DR   PANTHER; PTHR15301:SF11; PTHR15301:SF11; 1.
DR   Pfam; PF07281; INSIG; 1.
PE   2: Evidence at transcript level;
KW   Cholesterol metabolism {ECO:0000256|RuleBase:RU241113};
KW   Endoplasmic reticulum {ECO:0000256|RuleBase:RU241113};
KW   Lipid metabolism {ECO:0000256|RuleBase:RU241113};
KW   Membrane {ECO:0000256|RuleBase:RU241113};
KW   Steroid metabolism {ECO:0000256|RuleBase:RU241113};
KW   Sterol metabolism {ECO:0000256|RuleBase:RU241113};
KW   Transmembrane {ECO:0000256|RuleBase:RU241113};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU241113}.
FT   TRANSMEM     88    106       Helical. {ECO:0000256|RuleBase:RU241113}.
FT   TRANSMEM    126    146       Helical. {ECO:0000256|RuleBase:RU241113}.
FT   TRANSMEM    182    203       Helical. {ECO:0000256|RuleBase:RU241113}.
FT   TRANSMEM    210    229       Helical. {ECO:0000256|RuleBase:RU241113}.
FT   TRANSMEM    241    262       Helical. {ECO:0000256|RuleBase:RU241113}.
SQ   SEQUENCE   276 AA;  29696 MW;  11BEEA383CA72B2C CRC64;
     MPRLDDHLWR GPCAKGTKHR SHPRASARGL VAKAGEMINS SGSGPSLLAA HGAPGTDPTH
     GLQSTDVGGQ GSSGHVNSWH HHLVQRSLVL FSVGVVLALV LNLLQVQRNV TLFPDEVIAT
     IFSSAWWVPP CCGTAAAVVG LLYPCIDSHL GEPHKFKREW ASVMRCVAVF VGINHASAKL
     DFANNVQLSL TLAALSLGLW WTFDRSRSGL GLGITIAFLA TLITQLLVYN GVYQYTSPDF
     LYIRSWLPCI FFSGGVTVGN IGRQLAMGVP EKPHSD
//