ID I1WZP5_CAPHI Unreviewed; 276 AA. AC I1WZP5; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 11-JUL-2012, sequence version 1. DT 01-OCT-2014, entry version 11. DE RecName: Full=Insulin-induced gene protein {ECO:0000256|RuleBase:RU241113}; GN Name=INSIG1 {ECO:0000313|EMBL:AFI72778.1}; OS Capra hircus (Goat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Caprinae; Capra. OX NCBI_TaxID=9925 {ECO:0000313|EMBL:AFI72778.1}; RN [1] {ECO:0000313|EMBL:AFI72778.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Mammary gland {ECO:0000313|EMBL:AFI72778.1}; RA Wang H., Hu L., Luo J.; RT "Clone and Structural Analysis of Goat INSIG1 and Construction of RNA RT Interfering Adenovirus Vectors."; RL Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Mediates feedback control of cholesterol synthesis. CC {ECO:0000256|RuleBase:RU241113}. CC -!- SIMILARITY: Belongs to the INSIG family. CC {ECO:0000256|RuleBase:RU241113}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; JQ665439; AFI72778.1; -; mRNA. DR RefSeq; NP_001273017.1; NM_001286088.1. DR GeneID; 102183937; -. DR KEGG; chx:102183937; -. DR CTD; 3638; -. DR GO; GO:0008203; P:cholesterol metabolic process; IEA:InterPro. DR InterPro; IPR009904; INSIG-1. DR InterPro; IPR025929; INSIG_fam. DR PANTHER; PTHR15301:SF11; PTHR15301:SF11; 1. DR Pfam; PF07281; INSIG; 1. PE 2: Evidence at transcript level; KW Cholesterol metabolism {ECO:0000256|RuleBase:RU241113}; KW Lipid metabolism {ECO:0000256|RuleBase:RU241113}; KW Membrane {ECO:0000256|RuleBase:RU241113}; KW Steroid metabolism {ECO:0000256|RuleBase:RU241113}; KW Sterol metabolism; Transmembrane {ECO:0000256|RuleBase:RU241113}; KW Transmembrane helix {ECO:0000256|RuleBase:RU241113}. SQ SEQUENCE 276 AA; 29696 MW; 11BEEA383CA72B2C CRC64; MPRLDDHLWR GPCAKGTKHR SHPRASARGL VAKAGEMINS SGSGPSLLAA HGAPGTDPTH GLQSTDVGGQ GSSGHVNSWH HHLVQRSLVL FSVGVVLALV LNLLQVQRNV TLFPDEVIAT IFSSAWWVPP CCGTAAAVVG LLYPCIDSHL GEPHKFKREW ASVMRCVAVF VGINHASAKL DFANNVQLSL TLAALSLGLW WTFDRSRSGL GLGITIAFLA TLITQLLVYN GVYQYTSPDF LYIRSWLPCI FFSGGVTVGN IGRQLAMGVP EKPHSD //