ID I0AWZ8_9INFA Unreviewed; 466 AA. AC I0AWZ8; DT 13-JUN-2012, integrated into UniProtKB/TrEMBL. DT 13-JUN-2012, sequence version 1. DT 06-MAR-2013, entry version 5. DE SubName: Full=Neuraminidase; GN Name=NA; OS Influenza A virus (A/chicken/Guangdong/LYH12/2011(H9N2)). OC Viruses; ssRNA negative-strand viruses; Orthomyxoviridae; OC Influenzavirus A. OX NCBI_TaxID=1161301; RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=A/chicken/Guangdong/LYH12/2011; RA Xue Y., Xie Q., Yan Z., Wang J.; RT "Phylogenetic analysis of surface protein genes of H9N2 avian RT influenza viruses isolated from chicken in China in 2011."; RL Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, CC alpha-(2->8)- glycosidic linkages of terminal sialic acid residues CC in oligosaccharides, glycoproteins, glycolipids, colominic acid CC and synthetic substrates. CC -!- SUBUNIT: Homotetramer (By similarity). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; JQ770145; AFH53512.1; -; Viral_cRNA. DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-KW. DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. DR GO; GO:0055036; C:virion membrane; IEA:InterPro. DR GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro. DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro. DR Gene3D; 2.120.10.10; -; 1. DR InterPro; IPR001860; Glyco_hydro_34. DR InterPro; IPR011040; Sialidases. DR Pfam; PF00064; Neur; 1. DR SUPFAM; SSF50939; Sialidase; 1. PE 3: Inferred from homology; KW Disulfide bond; Glycosidase; Host cell membrane; Host membrane; KW Hydrolase; Membrane; Transmembrane; Transmembrane helix; Virion. SQ SEQUENCE 466 AA; 51612 MW; 9CCCDBDD25864292 CRC64; MNPNQKIIAI GSVSLIIAII CLLMQIAILT TTMTLHFRQN ECSNPSNNQV MPCEPIIIER NTVHLNSTTI EREICPKVAE YKNWSKPQCQ ITGFAPFSKD NSIRLSAGGD IWVTREPYVS CSLDKCYHFA LGQGTTLKNK HSNGTTHDRT PHRTLLMNEL GVPFHLGTKQ VCIAWSSSSC YDGKAWLHIC VTGDDKNATA SIIYDGMLVD SIGSWSKNIL RTQESECVCI NGTCAVVMTD GSASGKADTR VLFIREGKII NISPLSGSAQ HVEECSCYPR YPEVRCVCRD NWKGSNRPIL YINMADYSIE SSYVCSGLVG DTPRNDDSSS SSNCRDPNNE RGAPGVKGWA FDDGNDVWMG RTIKNGSRSG YETFRVVNGW TMANSKSQIN RQVIVDSDDW SGYSGIFSVE GKKCINRCFY VELIRGRPQE PRVWWTSNSI IVFCGTSGTY GTGSWPDGAN INFMPI //