ID I0AWZ8_9INFA Unreviewed; 466 AA. AC I0AWZ8; DT 13-JUN-2012, integrated into UniProtKB/TrEMBL. DT 13-JUN-2012, sequence version 1. DT 25-OCT-2017, entry version 32. DE RecName: Full=Neuraminidase {ECO:0000256|RuleBase:RU361252, ECO:0000256|SAAS:SAAS00114532}; DE EC=3.2.1.18 {ECO:0000256|RuleBase:RU361252, ECO:0000256|SAAS:SAAS00114514}; GN Name=NA {ECO:0000256|RuleBase:RU361252, ECO:0000313|EMBL:AFH53512.1}; OS Influenza A virus (A/chicken/Guangdong/LYH12/2011(H9N2)). OC Viruses; ssRNA viruses; ssRNA negative-strand viruses; OC Orthomyxoviridae; Influenzavirus A. OX NCBI_TaxID=1161301 {ECO:0000313|EMBL:AFH53512.1}; RN [1] {ECO:0000313|EMBL:AFH53512.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=A/chicken/Guangdong/LYH12/2011 {ECO:0000313|EMBL:AFH53512.1}; RX PubMed=24682938; DOI=10.1007/s11262-014-1060-1; RA Xue Y., Wang J.L., Yan Z.Q., Li G.W., Chen S.Y., Zhang X.B., Qin J.P., RA Li H.Y., Chang S., Chen F., Bee Y.Z., Xie Q.M.; RT "Sequence and phylogenetic analysis of surface protein genes of RT emerging H9N2 influenza viruses isolated from poultry in two RT geographical regions of China."; RL Virus Genes 48:479-485(2014). CC -!- CATALYTIC ACTIVITY: Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, CC alpha-(2->8)- glycosidic linkages of terminal sialic acid residues CC in oligosaccharides, glycoproteins, glycolipids, colominic acid CC and synthetic substrates. {ECO:0000256|RuleBase:RU361252, CC ECO:0000256|SAAS:SAAS00114528}. CC -!- COFACTOR: CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108; CC Evidence={ECO:0000256|RuleBase:RU361252, CC ECO:0000256|SAAS:SAAS00612833}; CC -!- SUBUNIT: Homotetramer. {ECO:0000256|RuleBase:RU361252, CC ECO:0000256|SAAS:SAAS00114476}. CC -!- SUBCELLULAR LOCATION: Host apical cell membrane CC {ECO:0000256|SAAS:SAAS00582107}; Single-pass type II membrane CC protein {ECO:0000256|SAAS:SAAS00582107}. CC -!- PTM: N-glycosylated. {ECO:0000256|RuleBase:RU361252}. CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 34 family. CC {ECO:0000256|RuleBase:RU361252, ECO:0000256|SAAS:SAAS00582269}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; JQ770145; AFH53512.1; -; Viral_cRNA. DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule. DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-UniRule. DR GO; GO:0052794; F:exo-alpha-(2->3)-sialidase activity; IEA:UniProtKB-UniRule. DR GO; GO:0052795; F:exo-alpha-(2->6)-sialidase activity; IEA:UniProtKB-UniRule. DR GO; GO:0052796; F:exo-alpha-(2->8)-sialidase activity; IEA:UniProtKB-UniRule. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-UniRule. DR GO; GO:0046761; P:viral budding from plasma membrane; IEA:InterPro. DR CDD; cd15483; Influenza_NA; 1. DR InterPro; IPR001860; Glyco_hydro_34. DR InterPro; IPR033654; Sialidase_Influenza_A/B. DR InterPro; IPR036278; Sialidase_sf. DR Pfam; PF00064; Neur; 1. DR SUPFAM; SSF50939; SSF50939; 1. PE 3: Inferred from homology; KW Calcium {ECO:0000256|RuleBase:RU361252, KW ECO:0000256|SAAS:SAAS00114513}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00114594}; KW Glycoprotein {ECO:0000256|RuleBase:RU361252}; KW Glycosidase {ECO:0000256|RuleBase:RU361252, KW ECO:0000256|SAAS:SAAS00114535}; KW Host cell membrane {ECO:0000256|RuleBase:RU361252, KW ECO:0000256|SAAS:SAAS00114522}; KW Host membrane {ECO:0000256|RuleBase:RU361252, KW ECO:0000256|SAAS:SAAS00114565}; KW Hydrolase {ECO:0000256|RuleBase:RU361252, KW ECO:0000256|SAAS:SAAS00114491}; KW Membrane {ECO:0000256|SAAS:SAAS00114461, ECO:0000256|SAM:Phobius}; KW Metal-binding {ECO:0000256|RuleBase:RU361252, KW ECO:0000256|SAAS:SAAS00114385}; KW Transmembrane {ECO:0000256|SAAS:SAAS00114524, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00114517, KW ECO:0000256|SAM:Phobius}; KW Virion {ECO:0000256|RuleBase:RU361252, ECO:0000256|SAAS:SAAS00114362}. FT TRANSMEM 7 29 Helical. {ECO:0000256|SAM:Phobius}. SQ SEQUENCE 466 AA; 51612 MW; 9CCCDBDD25864292 CRC64; MNPNQKIIAI GSVSLIIAII CLLMQIAILT TTMTLHFRQN ECSNPSNNQV MPCEPIIIER NTVHLNSTTI EREICPKVAE YKNWSKPQCQ ITGFAPFSKD NSIRLSAGGD IWVTREPYVS CSLDKCYHFA LGQGTTLKNK HSNGTTHDRT PHRTLLMNEL GVPFHLGTKQ VCIAWSSSSC YDGKAWLHIC VTGDDKNATA SIIYDGMLVD SIGSWSKNIL RTQESECVCI NGTCAVVMTD GSASGKADTR VLFIREGKII NISPLSGSAQ HVEECSCYPR YPEVRCVCRD NWKGSNRPIL YINMADYSIE SSYVCSGLVG DTPRNDDSSS SSNCRDPNNE RGAPGVKGWA FDDGNDVWMG RTIKNGSRSG YETFRVVNGW TMANSKSQIN RQVIVDSDDW SGYSGIFSVE GKKCINRCFY VELIRGRPQE PRVWWTSNSI IVFCGTSGTY GTGSWPDGAN INFMPI //