ID H9M5Z8_GALVR Unreviewed; 598 AA. AC H9M5Z8; DT 13-JUN-2012, integrated into UniProtKB/TrEMBL. DT 13-JUN-2012, sequence version 1. DT 08-MAY-2019, entry version 27. DE RecName: Full=NADH-ubiquinone oxidoreductase chain 5 {ECO:0000256|RuleBase:RU003404, ECO:0000256|SAAS:SAAS00061106}; DE EC=7.1.1.2 {ECO:0000256|RuleBase:RU003404}; GN Name=ND5 {ECO:0000313|EMBL:AES86250.1}; OS Galeopterus variegatus (Malayan flying lemur) (Cynocephalus OS variegatus). OG Mitochondrion {ECO:0000313|EMBL:AES86250.1}. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Dermoptera; Cynocephalidae; OC Galeopterus. OX NCBI_TaxID=482537 {ECO:0000313|EMBL:AES86250.1}; RN [1] {ECO:0000313|EMBL:AES86250.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Malayan {ECO:0000313|EMBL:AES86250.1}; RX PubMed=22464472; DOI=10.1016/j.jgg.2012.02.003; RA Xu L., Chen S.Y., Nie W.H., Jiang X.L., Yao Y.G.; RT "Evaluating the Phylogenetic Position of Chinese Tree Shrew (Tupaia RT belangeri chinensis) Based on Complete Mitochondrial Genome: RT Implication for Using Tree Shrew as an Alternative Experimental Animal RT to Primates in Biomedical Research."; RL J. Genet. Genomics 39:131-137(2012). CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory CC chain NADH dehydrogenase (Complex I) that is believed to belong to CC the minimal assembly required for catalysis. Complex I functions CC in the transfer of electrons from NADH to the respiratory chain. CC The immediate electron acceptor for the enzyme is believed to be CC ubiquinone. {ECO:0000256|RuleBase:RU003404, CC ECO:0000256|SAAS:SAAS00061107}. CC -!- CATALYTIC ACTIVITY: CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 CC H(+)(out) + NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, CC Rhea:RHEA-COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, CC ChEBI:CHEBI:17976, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; CC EC=7.1.1.2; Evidence={ECO:0000256|RuleBase:RU003404, CC ECO:0000256|SAAS:SAAS01122516}; CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane CC {ECO:0000256|SAAS:SAAS00061113}; Multi-pass membrane protein CC {ECO:0000256|SAAS:SAAS00061113}. CC -!- SIMILARITY: Belongs to the complex I subunit 5 family. CC {ECO:0000256|RuleBase:RU003404}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; JN800721; AES86250.1; -; Genomic_DNA. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell. DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW. DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:InterPro. DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro. DR InterPro; IPR010934; NADH_DH_su5_C. DR InterPro; IPR003945; NADHpl_OxRdtase_5. DR InterPro; IPR001750; ND/Mrp_mem. DR InterPro; IPR001516; Proton_antipo_N. DR Pfam; PF06455; NADH5_C; 1. DR Pfam; PF00361; Proton_antipo_M; 1. DR Pfam; PF00662; Proton_antipo_N; 1. DR TIGRFAMs; TIGR01974; NDH_I_L; 1. PE 3: Inferred from homology; KW Electron transport {ECO:0000256|SAAS:SAAS00448190}; KW Membrane {ECO:0000256|RuleBase:RU003404, KW ECO:0000256|SAAS:SAAS00464283}; KW Mitochondrion {ECO:0000256|RuleBase:RU003404, KW ECO:0000256|SAAS:SAAS00061115, ECO:0000313|EMBL:AES86250.1}; KW Mitochondrion inner membrane {ECO:0000256|SAAS:SAAS00448105}; KW NAD {ECO:0000256|RuleBase:RU003404, ECO:0000256|SAAS:SAAS00448053}; KW Respiratory chain {ECO:0000256|SAAS:SAAS00448195}; KW Translocase {ECO:0000256|SAAS:SAAS01106877}; KW Transmembrane {ECO:0000256|RuleBase:RU003404, KW ECO:0000256|SAAS:SAAS00464191}; KW Transmembrane helix {ECO:0000256|RuleBase:RU003404, KW ECO:0000256|SAAS:SAAS00464492}; KW Transport {ECO:0000256|RuleBase:RU003404, KW ECO:0000256|SAAS:SAAS00448204}; KW Ubiquinone {ECO:0000256|RuleBase:RU003404, KW ECO:0000256|SAAS:SAAS00448240}. FT TRANSMEM 34 52 Helical. {ECO:0000256|RuleBase:RU003404}. FT TRANSMEM 79 100 Helical. {ECO:0000256|RuleBase:RU003404}. FT TRANSMEM 112 129 Helical. {ECO:0000256|RuleBase:RU003404}. FT TRANSMEM 135 154 Helical. {ECO:0000256|RuleBase:RU003404}. FT TRANSMEM 166 185 Helical. {ECO:0000256|RuleBase:RU003404}. FT TRANSMEM 205 228 Helical. {ECO:0000256|RuleBase:RU003404}. FT TRANSMEM 240 258 Helical. {ECO:0000256|RuleBase:RU003404}. FT TRANSMEM 270 289 Helical. {ECO:0000256|RuleBase:RU003404}. FT TRANSMEM 296 314 Helical. {ECO:0000256|RuleBase:RU003404}. FT TRANSMEM 320 342 Helical. {ECO:0000256|RuleBase:RU003404}. FT TRANSMEM 363 381 Helical. {ECO:0000256|RuleBase:RU003404}. FT TRANSMEM 401 427 Helical. {ECO:0000256|RuleBase:RU003404}. FT TRANSMEM 581 597 Helical. {ECO:0000256|RuleBase:RU003404}. FT DOMAIN 60 116 Proton_antipo_N. {ECO:0000259|Pfam: FT PF00662}. FT DOMAIN 129 411 Proton_antipo_M. {ECO:0000259|Pfam: FT PF00361}. FT DOMAIN 417 596 NADH5_C. {ECO:0000259|Pfam:PF06455}. SQ SEQUENCE 598 AA; 66669 MW; C2C38ED92A270C06 CRC64; MNLTTSLMIT SLTILIIPTL SNMHKHYPYH VKTLTQVAFL TSLLPALTFI YSNQDAVTSN WHWITIQTLE LSINLKLDYF SMIFTPTALF ITWSIMEFSL WYMNSDPNIN KFFKYLLVFL IMMLILTTAN NLMQLLIGWE GVGIMSFLLI GWWYSRTDAN TAALQAIIYN RIGDIGFILA MAWFSTHSNT WNLQQLFILN TDPNLIPLVG LLLAAAGKSA QFGLHPWLPS AMEGPTPVSA LLHSSTMVVA GIFLLIRFHP LMENNKTIQT LALCLGALTT LFTAICALTQ NDIKKIIAFS TSSQLGLMMV TVGINQPYLA FLHICMHAFF KAMLFMCSGS IIHNLNNEQD IRKMGGLYKT MPLTSTSLTI GNLALTGMPF LTGFYSKDLI IETMNTSYTN AWALTVTLIA TSLTAAYSTR IIFLALLGQP RFPALMNTNE NNPHLANPTK RLMIGSIFAG FIISSNIPPT DIPQMTMPPY LKLSTLLITT FGFILALELC LDSLNPNTKS PSPLHNFSTL LGFFPTLAHR TVPHLNLTMS QNMASQTLDL TWLEKTIPKS IAHLQTLAAT NISNQKGLIK LYFLSFLITI TMTSLLII //