ID H8ZEK1_NEMA1 Unreviewed; 447 AA. AC H8ZEK1; DT 16-MAY-2012, integrated into UniProtKB/TrEMBL. DT 16-MAY-2012, sequence version 1. DT 02-OCT-2024, entry version 37. DE RecName: Full=Cation/H+ exchanger domain-containing protein {ECO:0000259|Pfam:PF00999}; GN ORFNames=NERG_02022 {ECO:0000313|EMBL:EHY64966.1}; OS Nematocida ausubeli (strain ATCC PRA-371 / ERTm2) (Nematode killer fungus). OC Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Nematocida. OX NCBI_TaxID=1913371 {ECO:0000313|EMBL:EHY64966.1}; RN [1] {ECO:0000313|EMBL:EHY64966.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=ERTm2 {ECO:0000313|EMBL:EHY64966.1}; RG The Broad Institute Genome Sequencing Platform; RG The Broad Institute Genome Sequencing Center for Infectious Disease; RA Cuomo C., Troemel E., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., RA Haas B., Abouelleil A., Alvarado L., Arachchi H.M., Berlin A., Brown A., RA Chapman S.B., Chen Z., Dunbar C., Freedman E., Gearin G., Gellesch M., RA Goldberg J., Griggs A., Gujja S., Heilman E.R., Heiman D., Howarth C., RA Larson L., Lui A., MacDonald P.J.P., Mehta T., Montmayeur A., Murphy C., RA Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T., Shenoy N., RA Sisk P., Stolte C., Sykes S., White J., Yandava C., Wortman J., Nusbaum C., RA Birren B.; RT "The Genome Sequence of Nematocida sp1 strain ERTm2."; RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; JH604637; EHY64966.1; -; Genomic_DNA. DR AlphaFoldDB; H8ZEK1; -. DR STRING; 944018.H8ZEK1; -. DR HOGENOM; CLU_008635_5_0_1; -. DR Proteomes; UP000005622; Unassembled WGS sequence. DR GO; GO:0005886; C:plasma membrane; IEA:InterPro. DR GO; GO:0015385; F:sodium:proton antiporter activity; IEA:InterPro. DR GO; GO:0120029; P:proton export across plasma membrane; IEA:InterPro. DR GO; GO:0042391; P:regulation of membrane potential; IEA:InterPro. DR GO; GO:0036376; P:sodium ion export across plasma membrane; IEA:InterPro. DR InterPro; IPR006153; Cation/H_exchanger. DR InterPro; IPR004712; Na+/H+_antiporter_fungi. DR PANTHER; PTHR31382; NA(+)/H(+) ANTIPORTER; 1. DR PANTHER; PTHR31382:SF1; SODIUM ION_PROTON EXCHANGER (EUROFUNG); 1. DR Pfam; PF00999; Na_H_Exchanger; 1. PE 4: Predicted; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 29..48 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 69..90 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 96..120 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 161..183 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 203..228 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 240..259 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 352..370 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 390..413 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 18..409 FT /note="Cation/H+ exchanger" FT /evidence="ECO:0000259|Pfam:PF00999" SQ SEQUENCE 447 AA; 50047 MW; 145518FC64EA36E6 CRC64; MQSFALCCSI LGGFILSFGL ISLFIKERLY IAETTVATLY GIICALICKD QKDTLPVESL KNTQFMFHFS HIVLSLQLVA VGVTVPKIFM KKNWKPLMVL LLPVMMIMYA VSSTIIKYVF SMDWLPAMMI GACITPTDPV LASAVIKGKF ANKYIPSRLR YLLAVESGAN DGLGFPLLVL PILLMQFKDS TEPVAGALRK WCIHTWGFEI LFAIVIGAVI GALARILLKY SVKKMLIDKE SFLAYSLALA ILVTGITAKM ESDDLLAVFV SGLFFAWDEE MVMDMKNSHV MEVVDLLFNQ SFFIVLGIIL PLDVLGWKSM LASVLILVFR RMPALLLMQL CGFLPEFTTR EILFAGWFGP IGVGAIFFAY HSMHELNSID KELADSVLEI VQAIVFSSIV VHGTTAPIIH MHLRRKQKKH KKTVINIYES DTEIERDNEN AQLQEII //