ID   H8XZV3_9INFA            Unreviewed;       230 AA.
AC   H8XZV3;
DT   16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT   16-MAY-2012, sequence version 1.
DT   06-JUL-2016, entry version 24.
DE   RecName: Full=Non-structural protein 1 {ECO:0000256|RuleBase:RU362113, ECO:0000256|SAAS:SAAS00141112};
DE            Short=NS1 {ECO:0000256|RuleBase:RU362113};
GN   Name=NS1 {ECO:0000313|EMBL:ADV39803.1};
GN   Synonyms=NS {ECO:0000256|RuleBase:RU362113};
OS   Influenza A virus (A/KOL/964/2007(H1N1)).
OC   Viruses; ssRNA viruses; ssRNA negative-strand viruses;
OC   Orthomyxoviridae; Influenzavirus A.
OX   NCBI_TaxID=943998 {ECO:0000313|EMBL:ADV39803.1};
RN   [1] {ECO:0000313|EMBL:ADV39803.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=A/KOL/964/2007 {ECO:0000313|EMBL:ADV39803.1};
RA   Sarkar-Dutta M., Chawla-Sarkar M.;
RL   Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ADV39803.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=A/KOL/964/2007 {ECO:0000313|EMBL:ADV39803.1};
RX   PubMed=22217077;
RA   Sarkar M., Chanda S., Chakrabarti S., Mazumdar J., Ganguly A.,
RA   Chadha M.S., Mishra A.C., Chawla-Sarkar M.;
RT   "Surveillance in eastern India (2007-2009) revealed reassortment event
RT   involving ns and PB1-F2 gene segments among co-circulating influenza a
RT   subtypes.";
RL   Virol. J. 9:3-3(2012).
CC   -!- SUBUNIT: Homodimer. Interacts with host TRIM25 (via coiled coil);
CC       this interaction specifically inhibits TRIM25 multimerization and
CC       TRIM25-mediated DDX58 CARD ubiquitination. Interacts with human
CC       EIF2AK2/PKR, CPSF4, IVNS1ABP and PABPN1.
CC       {ECO:0000256|RuleBase:RU362113}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm
CC       {ECO:0000256|SAAS:SAAS00596549}.
CC   -!- DOMAIN: The dsRNA-binding region is required for suppression of
CC       RNA silencing. {ECO:0000256|RuleBase:RU362113}.
CC   -!- SIMILARITY: Belongs to the influenza A viruses NS1 family.
CC       {ECO:0000256|RuleBase:RU362113, ECO:0000256|SAAS:SAAS00596488}.
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DR   EMBL; HQ853511; ADV39803.1; -; Viral_cRNA.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0039524; P:suppression by virus of host mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0039580; P:suppression by virus of host PKR activity; IEA:UniProtKB-KW.
DR   GO; GO:0039540; P:suppression by virus of host RIG-I activity; IEA:UniProtKB-KW.
DR   GO; GO:0039502; P:suppression by virus of host type I interferon-mediated signaling pathway; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.287.10; -; 1.
DR   InterPro; IPR000256; Flu_NS1.
DR   InterPro; IPR009068; S15_NS1_RNA-bd.
DR   Pfam; PF00600; Flu_NS1; 1.
DR   SUPFAM; SSF47060; SSF47060; 1.
PE   3: Inferred from homology;
KW   Eukaryotic host gene expression shutoff by virus
KW   {ECO:0000256|RuleBase:RU362113, ECO:0000256|SAAS:SAAS00490754};
KW   Host cytoplasm {ECO:0000256|RuleBase:RU362113,
KW   ECO:0000256|SAAS:SAAS00491311};
KW   Host gene expression shutoff by virus {ECO:0000256|RuleBase:RU362113,
KW   ECO:0000256|SAAS:SAAS00490948};
KW   Host mRNA suppression by virus {ECO:0000256|RuleBase:RU362113,
KW   ECO:0000256|SAAS:SAAS00491234};
KW   Host nucleus {ECO:0000256|RuleBase:RU362113,
KW   ECO:0000256|SAAS:SAAS00491032};
KW   Host-virus interaction {ECO:0000256|RuleBase:RU362113,
KW   ECO:0000256|SAAS:SAAS00491141};
KW   Inhibition of host innate immune response by virus
KW   {ECO:0000256|SAAS:SAAS00491089};
KW   Inhibition of host interferon signaling pathway by virus
KW   {ECO:0000256|SAAS:SAAS00490748};
KW   Inhibition of host PKR by virus {ECO:0000256|SAAS:SAAS00491222};
KW   Inhibition of host pre-mRNA processing by virus
KW   {ECO:0000256|RuleBase:RU362113, ECO:0000256|SAAS:SAAS00491387};
KW   Inhibition of host RIG-I by virus {ECO:0000256|SAAS:SAAS00491268};
KW   Inhibition of host RLR pathway by virus
KW   {ECO:0000256|SAAS:SAAS00491356};
KW   Interferon antiviral system evasion {ECO:0000256|RuleBase:RU362113,
KW   ECO:0000256|SAAS:SAAS00490884};
KW   RNA-binding {ECO:0000256|RuleBase:RU362113,
KW   ECO:0000256|SAAS:SAAS00491002};
KW   Viral immunoevasion {ECO:0000256|SAAS:SAAS00491222}.
SQ   SEQUENCE   230 AA;  25786 MW;  F99B5310CA12F196 CRC64;
     MDSHTVSSFQ VDCFLWHVRK QVADQDLGDA PFLDRLRRDQ KSLKGRGSTL GLNIETATCV
     GKQIVERILK EESDEALKMT MASALASRYL TDMTVEEMSR DWFMLMPKQK VAGPLCVRMD
     QAIMDKNIIL KANFSVIFDR LENLTLLRAF TEEGAIVGEI SPLPSFPGHT NEDVKNAIGV
     LIGGLEWNDN TVRVSETLQR FAWRSSNETG GPPFTTTQNR KMAGTTRSEV
//