ID H7C480_HUMAN Unreviewed; 105 AA. AC H7C480; DT 18-APR-2012, integrated into UniProtKB/TrEMBL. DT 18-APR-2012, sequence version 1. DT 02-OCT-2024, entry version 71. DE SubName: Full=Cubilin {ECO:0000313|Ensembl:ENSP00000415970.1}; DE Flags: Fragment; GN Name=CUBN {ECO:0000313|Ensembl:ENSP00000415970.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000415970.1, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000415970.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=11237011; DOI=10.1038/35057062; RG International Human Genome Sequencing Consortium; RA Lander E.S., Linton L.M., Birren B., Nusbaum C., Zody M.C., Baldwin J., RA Devon K., Dewar K., Doyle M., FitzHugh W., Funke R., Gage D., Harris K., RA Heaford A., Howland J., Kann L., Lehoczky J., LeVine R., McEwan P., RA McKernan K., Meldrim J., Mesirov J.P., Miranda C., Morris W., Naylor J., RA Raymond C., Rosetti M., Santos R., Sheridan A., Sougnez C., RA Stange-Thomann N., Stojanovic N., Subramanian A., Wyman D., Rogers J., RA Sulston J., Ainscough R., Beck S., Bentley D., Burton J., Clee C., RA Carter N., Coulson A., Deadman R., Deloukas P., Dunham A., Dunham I., RA Durbin R., French L., Grafham D., Gregory S., Hubbard T., Humphray S., RA Hunt A., Jones M., Lloyd C., McMurray A., Matthews L., Mercer S., Milne S., RA Mullikin J.C., Mungall A., Plumb R., Ross M., Shownkeen R., Sims S., RA Waterston R.H., Wilson R.K., Hillier L.W., McPherson J.D., Marra M.A., RA Mardis E.R., Fulton L.A., Chinwalla A.T., Pepin K.H., Gish W.R., RA Chissoe S.L., Wendl M.C., Delehaunty K.D., Miner T.L., Delehaunty A., RA Kramer J.B., Cook L.L., Fulton R.S., Johnson D.L., Minx P.J., Clifton S.W., RA Hawkins T., Branscomb E., Predki P., Richardson P., Wenning S., Slezak T., RA Doggett N., Cheng J.F., Olsen A., Lucas S., Elkin C., Uberbacher E., RA Frazier M., Gibbs R.A., Muzny D.M., Scherer S.E., Bouck J.B., RA Sodergren E.J., Worley K.C., Rives C.M., Gorrell J.H., Metzker M.L., RA Naylor S.L., Kucherlapati R.S., Nelson D.L., Weinstock G.M., Sakaki Y., RA Fujiyama A., Hattori M., Yada T., Toyoda A., Itoh T., Kawagoe C., RA Watanabe H., Totoki Y., Taylor T., Weissenbach J., Heilig R., Saurin W., RA Artiguenave F., Brottier P., Bruls T., Pelletier E., Robert C., Wincker P., RA Smith D.R., Doucette-Stamm L., Rubenfield M., Weinstock K., Lee H.M., RA Dubois J., Rosenthal A., Platzer M., Nyakatura G., Taudien S., Rump A., RA Yang H., Yu J., Wang J., Huang G., Gu J., Hood L., Rowen L., Madan A., RA Qin S., Davis R.W., Federspiel N.A., Abola A.P., Proctor M.J., Myers R.M., RA Schmutz J., Dickson M., Grimwood J., Cox D.R., Olson M.V., Kaul R., RA Raymond C., Shimizu N., Kawasaki K., Minoshima S., Evans G.A., RA Athanasiou M., Schultz R., Roe B.A., Chen F., Pan H., Ramser J., RA Lehrach H., Reinhardt R., McCombie W.R., de la Bastide M., Dedhia N., RA Blocker H., Hornischer K., Nordsiek G., Agarwala R., Aravind L., RA Bailey J.A., Bateman A., Batzoglou S., Birney E., Bork P., Brown D.G., RA Burge C.B., Cerutti L., Chen H.C., Church D., Clamp M., Copley R.R., RA Doerks T., Eddy S.R., Eichler E.E., Furey T.S., Galagan J., Gilbert J.G., RA Harmon C., Hayashizaki Y., Haussler D., Hermjakob H., Hokamp K., Jang W., RA Johnson L.S., Jones T.A., Kasif S., Kaspryzk A., Kennedy S., Kent W.J., RA Kitts P., Koonin E.V., Korf I., Kulp D., Lancet D., Lowe T.M., RA McLysaght A., Mikkelsen T., Moran J.V., Mulder N., Pollara V.J., RA Ponting C.P., Schuler G., Schultz J., Slater G., Smit A.F., Stupka E., RA Szustakowski J., Thierry-Mieg D., Thierry-Mieg J., Wagner L., Wallis J., RA Wheeler R., Williams A., Wolf Y.I., Wolfe K.H., Yang S.P., Yeh R.F., RA Collins F., Guyer M.S., Peterson J., Felsenfeld A., Wetterstrand K.A., RA Patrinos A., Morgan M.J., de Jong P., Catanese J.J., Osoegawa K., RA Shizuya H., Choi S., Chen Y.J.; RT "Initial sequencing and analysis of the human genome."; RL Nature 409:860-921(2001). RN [2] {ECO:0000313|Ensembl:ENSP00000415970.1, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15164054; DOI=10.1038/nature02462; RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., RA Hunt S.E., Andrews T.D., Gilbert J.G., Swarbreck D., Ashurst J.L., RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I., RA Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., RA Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., RA Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., RA Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., RA Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., RA Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., RA Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., RA Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., RA Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., RA Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., RA Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., RA Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., RA Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., RA Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., RA Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., RA Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., RA Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., RA Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., RA Fechtel K., Bentley D., Durbin R., Hubbard T., Doucette-Stamm L., Beck S., RA Smith D.R., Rogers J.; RT "The DNA sequence and comparative analysis of human chromosome 10."; RL Nature 429:375-381(2004). RN [3] {ECO:0000313|Ensembl:ENSP00000415970.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15496913; DOI=10.1038/nature03001; RG International Human Genome Sequencing Consortium; RT "Finishing the euchromatic sequence of the human genome."; RL Nature 431:931-945(2004). RN [4] {ECO:0000313|Ensembl:ENSP00000415970.1} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUN-2024) to UniProtKB. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC067747; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL365215; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL596445; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL731551; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR AlphaFoldDB; H7C480; -. DR SMR; H7C480; -. DR MassIVE; H7C480; -. DR PeptideAtlas; H7C480; -. DR ProteomicsDB; 45582; -. DR Antibodypedia; 56802; 196 antibodies from 20 providers. DR Ensembl; ENST00000433666.5; ENSP00000415970.1; ENSG00000107611.16. DR UCSC; uc057san.1; human. DR HGNC; HGNC:2548; CUBN. DR VEuPathDB; HostDB:ENSG00000107611; -. DR GeneTree; ENSGT00940000155299; -. DR HOGENOM; CLU_2242604_0_0_1; -. DR ChiTaRS; CUBN; human. DR Proteomes; UP000005640; Chromosome 10. DR Bgee; ENSG00000107611; Expressed in adult organism and 129 other cell types or tissues. DR ExpressionAtlas; H7C480; baseline and differential. DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro. DR CDD; cd00054; EGF_CA; 2. DR Gene3D; 2.10.25.10; Laminin; 2. DR InterPro; IPR053119; Cubilin_domain. DR InterPro; IPR001881; EGF-like_Ca-bd_dom. DR InterPro; IPR000742; EGF-like_dom. DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site. DR InterPro; IPR049883; NOTCH1_EGF-like. DR PANTHER; PTHR47761:SF1; C-TYPE LECTIN; 1. DR PANTHER; PTHR47761; C-TYPE LECTIN-RELATED; 1. DR Pfam; PF00008; EGF; 1. DR Pfam; PF07645; EGF_CA; 1. DR SMART; SM00181; EGF; 1. DR SMART; SM00179; EGF_CA; 2. DR SUPFAM; SSF57196; EGF/Laminin; 2. DR PROSITE; PS00010; ASX_HYDROXYL; 1. DR PROSITE; PS00022; EGF_1; 1. DR PROSITE; PS50026; EGF_3; 1. PE 1: Evidence at protein level; KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE- KW ProRule:PRU00076}; KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE- KW ProRule:PRU00076}; KW Proteomics identification {ECO:0007829|PeptideAtlas:H7C480, KW ECO:0007829|ProteomicsDB:H7C480}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}. FT DOMAIN 19..55 FT /note="EGF-like" FT /evidence="ECO:0000259|PROSITE:PS50026" FT REGION 86..105 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT DISULFID 45..54 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076" FT NON_TER 1 FT /evidence="ECO:0000313|Ensembl:ENSP00000415970.1" SQ SEQUENCE 105 AA; 11629 MW; 868F727354B20E8A CRC64; NSKLVDLERK FQGLQQTVDK KVCSSNPCQN GGTCLNLHDS FFCICPPQWK GPLCSADVNE CEIYSGTPLS CQNGGTCVNT MGSYRNPCSN IPKEPEEGSR DWHRE //