ID H7C480_HUMAN Unreviewed; 105 AA. AC H7C480; DT 18-APR-2012, integrated into UniProtKB/TrEMBL. DT 18-APR-2012, sequence version 1. DT 02-JUN-2021, entry version 55. DE SubName: Full=Cubilin {ECO:0000313|Ensembl:ENSP00000415970}; DE Flags: Fragment; GN Name=CUBN {ECO:0000313|Ensembl:ENSP00000415970}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000415970, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000415970, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15164054; DOI=10.1038/nature02462; RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P., RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., RA Durbin R., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.; RT "The DNA sequence and comparative analysis of human chromosome 10."; RL Nature 429:375-381(2004). RN [2] {ECO:0000313|Ensembl:ENSP00000415970} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC067747; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL365215; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL596445; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL731551; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PeptideAtlas; H7C480; -. DR PRIDE; H7C480; -. DR ProteomicsDB; 45582; -. DR Antibodypedia; 56802; 163 antibodies. DR Ensembl; ENST00000433666; ENSP00000415970; ENSG00000107611. DR UCSC; uc057san.1; human. DR HGNC; HGNC:2548; CUBN. DR OpenTargets; ENSG00000107611; -. DR VEuPathDB; HostDB:ENSG00000107611.14; -. DR GeneTree; ENSGT00940000155299; -. DR HOGENOM; CLU_2242604_0_0_1; -. DR ChiTaRS; CUBN; human. DR Proteomes; UP000005640; Chromosome 10. DR Bgee; ENSG00000107611; Expressed in cortex of kidney and 150 other tissues. DR ExpressionAtlas; H7C480; baseline and differential. DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro. DR InterPro; IPR001881; EGF-like_Ca-bd_dom. DR InterPro; IPR000742; EGF-like_dom. DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site. DR Pfam; PF00008; EGF; 1. DR Pfam; PF07645; EGF_CA; 1. DR SMART; SM00181; EGF; 1. DR SMART; SM00179; EGF_CA; 2. DR PROSITE; PS00010; ASX_HYDROXYL; 1. DR PROSITE; PS00022; EGF_1; 1. DR PROSITE; PS50026; EGF_3; 1. PE 1: Evidence at protein level; KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE- KW ProRule:PRU00076}; KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE- KW ProRule:PRU00076}; KW Proteomics identification {ECO:0007829|PeptideAtlas:H7C480, KW ECO:0007829|ProteomicsDB:H7C480}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}. FT DOMAIN 19..55 FT /note="EGF-like" FT /evidence="ECO:0000259|PROSITE:PS50026" FT REGION 86..105 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT DISULFID 45..54 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076" FT NON_TER 1 FT /evidence="ECO:0000313|Ensembl:ENSP00000415970" SQ SEQUENCE 105 AA; 11629 MW; 868F727354B20E8A CRC64; NSKLVDLERK FQGLQQTVDK KVCSSNPCQN GGTCLNLHDS FFCICPPQWK GPLCSADVNE CEIYSGTPLS CQNGGTCVNT MGSYRNPCSN IPKEPEEGSR DWHRE //