ID H7C480_HUMAN Unreviewed; 105 AA. AC H7C480; DT 18-APR-2012, integrated into UniProtKB/TrEMBL. DT 18-APR-2012, sequence version 1. DT 31-JUL-2019, entry version 46. DE SubName: Full=Cubilin {ECO:0000313|Ensembl:ENSP00000415970}; DE Flags: Fragment; GN Name=CUBN {ECO:0000313|Ensembl:ENSP00000415970}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000415970, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000415970, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15164054; DOI=10.1038/nature02462; RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P., RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., RA Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., RA Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., RA Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., RA Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., RA Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., RA Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., RA Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., RA Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., RA Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., RA Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., RA Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., RA Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., RA Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., RA Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., RA Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., RA Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., RA Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., RA Siebert R., Fechtel K., Bentley D., Durbin R., Hubbard T., RA Doucette-Stamm L., Beck S., Smith D.R., Rogers J.; RT "The DNA sequence and comparative analysis of human chromosome 10."; RL Nature 429:375-381(2004). RN [2] {ECO:0000313|Ensembl:ENSP00000415970} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation CC of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC067747; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL365215; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL596445; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL731551; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PeptideAtlas; H7C480; -. DR PRIDE; H7C480; -. DR ProteomicsDB; 45582; -. DR Ensembl; ENST00000433666; ENSP00000415970; ENSG00000107611. DR UCSC; uc057san.1; human. DR HGNC; HGNC:2548; CUBN. DR OpenTargets; ENSG00000107611; -. DR eggNOG; KOG3714; Eukaryota. DR eggNOG; ENOG410ZPX7; LUCA. DR GeneTree; ENSGT00940000155299; -. DR ChiTaRS; CUBN; human. DR Proteomes; UP000005640; Chromosome 10. DR Bgee; ENSG00000107611; Expressed in 121 organ(s), highest expression level in cortex of kidney. DR ExpressionAtlas; H7C480; baseline and differential. DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro. DR InterPro; IPR001881; EGF-like_Ca-bd_dom. DR InterPro; IPR013032; EGF-like_CS. DR InterPro; IPR000742; EGF-like_dom. DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site. DR Pfam; PF00008; EGF; 1. DR Pfam; PF07645; EGF_CA; 1. DR SMART; SM00181; EGF; 1. DR SMART; SM00179; EGF_CA; 2. DR PROSITE; PS00010; ASX_HYDROXYL; 1. DR PROSITE; PS00022; EGF_1; 1. DR PROSITE; PS50026; EGF_3; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00076, KW ECO:0000256|SAAS:SAAS00601599}; KW EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076, KW ECO:0000256|SAAS:SAAS00602928}; KW Proteomics identification {ECO:0000213|PeptideAtlas:H7C480, KW ECO:0000213|ProteomicsDB:H7C480}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}. FT DOMAIN 19 55 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT REGION 86 105 Disordered. {ECO:0000256|SAM:MobiDB- FT lite}. FT DISULFID 45 54 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSP00000415970}. SQ SEQUENCE 105 AA; 11629 MW; 868F727354B20E8A CRC64; NSKLVDLERK FQGLQQTVDK KVCSSNPCQN GGTCLNLHDS FFCICPPQWK GPLCSADVNE CEIYSGTPLS CQNGGTCVNT MGSYRNPCSN IPKEPEEGSR DWHRE //