ID H6V5F6_BOVIN Unreviewed; 352 AA. AC H6V5F6; DT 18-APR-2012, integrated into UniProtKB/TrEMBL. DT 18-APR-2012, sequence version 1. DT 29-MAY-2024, entry version 45. DE SubName: Full=MHC class I antigen {ECO:0000313|EMBL:AFA35807.1}; DE Flags: Fragment; GN Name=BoLA-N {ECO:0000313|EMBL:AFA35807.1}; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; OC Bovinae; Bos. OX NCBI_TaxID=9913 {ECO:0000313|EMBL:AFA35807.1}; RN [1] {ECO:0000313|EMBL:AFA35807.1} RP NUCLEOTIDE SEQUENCE. RA Thomas A.J., Wilhelm A., Davies C.J.; RT "Novel bovine MHC class I and class II sequences discovered by massively RT parallel pyrosequencing."; RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|ARBA:ARBA00002297}. CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single- CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|ARBA:ARBA00006909, ECO:0000256|RuleBase:RU004439}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; JN792877; AFA35807.1; -; Genomic_DNA. DR AlphaFoldDB; H6V5F6; -. DR GO; GO:0009897; C:external side of plasma membrane; IEA:TreeGrafter. DR GO; GO:0005615; C:extracellular space; IEA:TreeGrafter. DR GO; GO:0098553; C:lumenal side of endoplasmic reticulum membrane; IEA:UniProt. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0030670; C:phagocytic vesicle membrane; IEA:UniProt. DR GO; GO:0042605; F:peptide antigen binding; IEA:TreeGrafter. DR GO; GO:0005102; F:signaling receptor binding; IEA:TreeGrafter. DR GO; GO:0002486; P:antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent; IEA:TreeGrafter. DR GO; GO:0002476; P:antigen processing and presentation of endogenous peptide antigen via MHC class Ib; IEA:TreeGrafter. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR GO; GO:0001916; P:positive regulation of T cell mediated cytotoxicity; IEA:TreeGrafter. DR CDD; cd07698; IgC1_MHC_I_alpha3; 1. DR Gene3D; 2.60.40.10; Immunoglobulins; 1. DR Gene3D; 3.30.500.10; MHC class I-like antigen recognition-like; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR PANTHER; PTHR16675:SF242; CLASS IB MHC ANTIGEN QA-2-RELATED; 1. DR PANTHER; PTHR16675; MHC CLASS I-RELATED; 1. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; Immunoglobulin; 1. DR SUPFAM; SSF54452; MHC antigen-recognition domain; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180}; KW Immunity {ECO:0000256|ARBA:ARBA00022451}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|ARBA:ARBA00022451}; Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1..15 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 16..352 FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5013311404" FT TRANSMEM 296..319 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 200..286 FT /note="Ig-like" FT /evidence="ECO:0000259|PROSITE:PS50835" FT REGION 326..352 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 329..346 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:AFA35807.1" SQ SEQUENCE 352 AA; 39872 MW; 335747F4C21BE19D CRC64; FVLLLGALVL TETRAGSHSL RYFYTGVSRP GLGEPRFFAV GYVDDTQIAR FDSDAWNPRM EPRAPWMEQK GPEYWEEMTR DAKEDQQRSQ LCLNTLRGYY NQSEAGSHTF QQIFGCDVGP DGRLLLGFTQ FGYDGRDYIA LNEDLRSWTA ADTAAQITKR KWEAAGAAER FRNYLEGTCV EWLRRYLENG KDALLRADPP KAHVTHHPIS DREVTLRCWA LGFYPKEISL TWQRNGEDLT QDMELVETRP SGDGNFQKWA ALVVPSGEEQ RYTCHVQHEG LQEPLTLRWE PPQTSFLTMG IIVGLVLLVV AVVAGAVIWR KKRSGEKRQT YSQAASGDSD QGSDVSLTVP KV //