ID H6V5F6_BOVIN Unreviewed; 352 AA. AC H6V5F6; DT 18-APR-2012, integrated into UniProtKB/TrEMBL. DT 18-APR-2012, sequence version 1. DT 04-FEB-2015, entry version 13. DE SubName: Full=MHC class I antigen {ECO:0000313|EMBL:AFA35807.1}; DE Flags: Fragment; GN Name=BoLA-N {ECO:0000313|EMBL:AFA35807.1}; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Bovinae; Bos. OX NCBI_TaxID=9913 {ECO:0000313|EMBL:AFA35807.1}; RN [1] {ECO:0000313|EMBL:AFA35807.1} RP NUCLEOTIDE SEQUENCE. RA Thomas A.J., Wilhelm A., Davies C.J.; RT "Novel bovine MHC class I and class II sequences discovered by RT massively parallel pyrosequencing."; RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00058813}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC -!- SIMILARITY: Contains Ig-like C1-type (immunoglobulin-like) domain. CC {ECO:0000256|SAAS:SAAS00058809}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; JN792877; AFA35807.1; -; Genomic_DNA. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0042605; F:peptide antigen binding; IEA:InterPro. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR GO; GO:0001916; P:positive regulation of T cell mediated cytotoxicity; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR027648; MHC_I_a. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Disulfide bond {ECO:0000256|SAAS:SAAS00058793}; KW Immunity {ECO:0000256|SAAS:SAAS00058788}; KW Membrane {ECO:0000256|SAAS:SAAS00058838}; KW MHC I {ECO:0000256|SAAS:SAAS00058784}; KW Transmembrane {ECO:0000256|SAAS:SAAS00058845}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00058834}. FT NON_TER 1 1 {ECO:0000313|EMBL:AFA35807.1}. SQ SEQUENCE 352 AA; 39872 MW; 335747F4C21BE19D CRC64; FVLLLGALVL TETRAGSHSL RYFYTGVSRP GLGEPRFFAV GYVDDTQIAR FDSDAWNPRM EPRAPWMEQK GPEYWEEMTR DAKEDQQRSQ LCLNTLRGYY NQSEAGSHTF QQIFGCDVGP DGRLLLGFTQ FGYDGRDYIA LNEDLRSWTA ADTAAQITKR KWEAAGAAER FRNYLEGTCV EWLRRYLENG KDALLRADPP KAHVTHHPIS DREVTLRCWA LGFYPKEISL TWQRNGEDLT QDMELVETRP SGDGNFQKWA ALVVPSGEEQ RYTCHVQHEG LQEPLTLRWE PPQTSFLTMG IIVGLVLLVV AVVAGAVIWR KKRSGEKRQT YSQAASGDSD QGSDVSLTVP KV //