ID H6UPA4_LOXCY Unreviewed; 175 AA.
AC H6UPA4;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 12-AUG-2020, entry version 32.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 6 {ECO:0000256|RuleBase:RU004430};
DE EC=7.1.1.2 {ECO:0000256|RuleBase:RU004430};
GN Name=ND6 {ECO:0000313|EMBL:AEQ59312.1};
OS Loxodonta cyclotis (African forest elephant).
OG Mitochondrion {ECO:0000313|EMBL:AEQ59312.1}.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=99490 {ECO:0000313|EMBL:AEQ59312.1};
RN [1] {ECO:0000313|EMBL:AEQ59312.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Coco {ECO:0000313|EMBL:AEQ59312.1};
RC TISSUE=Blood {ECO:0000313|EMBL:AEQ59312.1};
RX PubMed=22260276; DOI=10.1111/j.1365-294X.2012.05461.x;
RA Brandt A.L., Ishida Y., Georgiadis N.J., Roca A.L.;
RT "Forest elephant mitochondrial genomes reveal that elephantid
RT diversification in Africa tracked climate transitions.";
RL Mol. Ecol. 21:1175-1189(2012).
RN [2] {ECO:0000313|EMBL:AFX94966.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=SL0001 {ECO:0000313|EMBL:AFX94966.1};
RX PubMed=23798975; DOI=10.1111/j.1752-4571.2012.00286.x;
RA Ishida Y., Georgiadis N.J., Hondo T., Roca A.L.;
RT "Triangulating the provenance of African elephants using mitochondrial
RT DNA.";
RL Evol. Appl. 6:253-265(2013).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone.
CC {ECO:0000256|ARBA:ARBA00002539, ECO:0000256|RuleBase:RU004430}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC Evidence={ECO:0000256|ARBA:ARBA00000766,
CC ECO:0000256|RuleBase:RU004430};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion
CC membrane {ECO:0000256|ARBA:ARBA00004225,
CC ECO:0000256|RuleBase:RU004430}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004225, ECO:0000256|RuleBase:RU004430}.
CC -!- SIMILARITY: Belongs to the complex I subunit 6 family.
CC {ECO:0000256|ARBA:ARBA00005698, ECO:0000256|RuleBase:RU004430}.
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DR EMBL; JN673264; AEQ59312.1; -; Genomic_DNA.
DR EMBL; JQ438501; AFX94966.1; -; Genomic_DNA.
DR RefSeq; YP_007626834.1; NC_020759.1.
DR GeneID; 14842600; -.
DR CTD; 4541; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-UniRule.
DR Gene3D; 1.20.120.1200; -; 1.
DR InterPro; IPR001457; NADH_UbQ/plastoQ_OxRdtase_su6.
DR InterPro; IPR042106; Nuo/plastoQ_OxRdtase_6_NuoJ.
DR Pfam; PF00499; Oxidored_q3; 1.
PE 3: Inferred from homology;
KW Electron transport {ECO:0000256|RuleBase:RU004430};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU004430};
KW Mitochondrion {ECO:0000256|RuleBase:RU004430, ECO:0000313|EMBL:AEQ59312.1};
KW NAD {ECO:0000256|RuleBase:RU004430};
KW Respiratory chain {ECO:0000256|RuleBase:RU004430};
KW Translocase {ECO:0000256|RuleBase:RU004430};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU004430};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU004430}; Transport {ECO:0000256|RuleBase:RU004430};
KW Ubiquinone {ECO:0000256|RuleBase:RU004430}.
FT TRANSMEM 25..43
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004430"
FT TRANSMEM 50..74
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004430"
FT TRANSMEM 86..107
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004430"
FT TRANSMEM 114..136
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004430"
FT TRANSMEM 148..168
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004430"
SQ SEQUENCE 175 AA; 19022 MW; 8C91189B340559E9 CRC64;
MMYIVFIMSV LYVVGFIGFS SKPSPVYGGM SLVVSGGLGC GIIMSSGGSF LGLVVFLVYL
GGMMVVFGYT IAMATEEYPE TWGSNVVILS AFLVGLLMEI SMVMWLLSGE HELMGFYFGG
LGGLVVLGEG GFEYVREDYS GGASLYSYGF WFLAMAGWML FVSIFIAIEV TRKRY
//