ID   H6UPA4_LOXCY            Unreviewed;       175 AA.
AC   H6UPA4;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   13-FEB-2019, entry version 29.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 6 {ECO:0000256|RuleBase:RU004430};
DE            EC=7.1.1.2 {ECO:0000256|RuleBase:RU004430};
GN   Name=ND6 {ECO:0000313|EMBL:AEQ59312.1};
OS   Loxodonta cyclotis (African forest elephant).
OG   Mitochondrion {ECO:0000313|EMBL:AEQ59312.1}.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX   NCBI_TaxID=99490 {ECO:0000313|EMBL:AEQ59312.1};
RN   [1] {ECO:0000313|EMBL:AEQ59312.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Coco {ECO:0000313|EMBL:AEQ59312.1};
RC   TISSUE=Blood {ECO:0000313|EMBL:AEQ59312.1};
RX   PubMed=22260276; DOI=10.1111/j.1365-294X.2012.05461.x;
RA   Brandt A.L., Ishida Y., Georgiadis N.J., Roca A.L.;
RT   "Forest elephant mitochondrial genomes reveal that elephantid
RT   diversification in Africa tracked climate transitions.";
RL   Mol. Ecol. 21:1175-1189(2012).
RN   [2] {ECO:0000313|EMBL:AFX94966.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=SL0001 {ECO:0000313|EMBL:AFX94966.1};
RX   PubMed=23798975; DOI=10.1111/j.1752-4571.2012.00286.x;
RA   Ishida Y., Georgiadis N.J., Hondo T., Roca A.L.;
RT   "Triangulating the provenance of African elephants using mitochondrial
RT   DNA.";
RL   Evol Appl 6:253-265(2013).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory
CC       chain NADH dehydrogenase (Complex I) that is believed to belong to
CC       the minimal assembly required for catalysis. Complex I functions
CC       in the transfer of electrons from NADH to the respiratory chain.
CC       The immediate electron acceptor for the enzyme is believed to be
CC       ubiquinone. {ECO:0000256|RuleBase:RU004430}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4
CC         H(+)(out) + NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565,
CC         Rhea:RHEA-COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389,
CC         ChEBI:CHEBI:17976, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945;
CC         EC=7.1.1.2; Evidence={ECO:0000256|RuleBase:RU004430};
CC   -!- SUBCELLULAR LOCATION: Mitochondrion membrane
CC       {ECO:0000256|RuleBase:RU004430}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU004430}.
CC   -!- SIMILARITY: Belongs to the complex I subunit 6 family.
CC       {ECO:0000256|RuleBase:RU004430, ECO:0000256|SAAS:SAAS00585382}.
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DR   EMBL; JN673264; AEQ59312.1; -; Genomic_DNA.
DR   EMBL; JQ438501; AFX94966.1; -; Genomic_DNA.
DR   RefSeq; YP_007626834.1; NC_020759.1.
DR   GeneID; 14842600; -.
DR   CTD; 4541; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-UniRule.
DR   InterPro; IPR001457; NADH_UbQ/plastoQ_OxRdtase_su6.
DR   Pfam; PF00499; Oxidored_q3; 1.
PE   3: Inferred from homology;
KW   Electron transport {ECO:0000256|RuleBase:RU004430};
KW   Membrane {ECO:0000256|RuleBase:RU004430,
KW   ECO:0000256|SAAS:SAAS00477717};
KW   Mitochondrion {ECO:0000256|RuleBase:RU004430,
KW   ECO:0000313|EMBL:AEQ59312.1};
KW   NAD {ECO:0000256|RuleBase:RU004430, ECO:0000256|SAAS:SAAS00119311};
KW   Respiratory chain {ECO:0000256|RuleBase:RU004430};
KW   Translocase {ECO:0000256|RuleBase:RU004430,
KW   ECO:0000256|SAAS:SAAS01134433};
KW   Transmembrane {ECO:0000256|RuleBase:RU004430,
KW   ECO:0000256|SAAS:SAAS00119307};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU004430,
KW   ECO:0000256|SAAS:SAAS00119309};
KW   Transport {ECO:0000256|RuleBase:RU004430};
KW   Ubiquinone {ECO:0000256|RuleBase:RU004430}.
FT   TRANSMEM     25     43       Helical. {ECO:0000256|RuleBase:RU004430}.
FT   TRANSMEM     50     74       Helical. {ECO:0000256|RuleBase:RU004430}.
FT   TRANSMEM     86    107       Helical. {ECO:0000256|RuleBase:RU004430}.
FT   TRANSMEM    114    136       Helical. {ECO:0000256|RuleBase:RU004430}.
FT   TRANSMEM    148    168       Helical. {ECO:0000256|RuleBase:RU004430}.
SQ   SEQUENCE   175 AA;  19022 MW;  8C91189B340559E9 CRC64;
     MMYIVFIMSV LYVVGFIGFS SKPSPVYGGM SLVVSGGLGC GIIMSSGGSF LGLVVFLVYL
     GGMMVVFGYT IAMATEEYPE TWGSNVVILS AFLVGLLMEI SMVMWLLSGE HELMGFYFGG
     LGGLVVLGEG GFEYVREDYS GGASLYSYGF WFLAMAGWML FVSIFIAIEV TRKRY
//