ID   H6UPA4_LOXCY            Unreviewed;       175 AA.
AC   H6UPA4;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   10-MAY-2017, entry version 25.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 6 {ECO:0000256|RuleBase:RU004430};
DE            EC=1.6.5.3 {ECO:0000256|RuleBase:RU004430};
GN   Name=ND6 {ECO:0000313|EMBL:AEQ59312.1};
OS   Loxodonta cyclotis (African forest elephant).
OG   Mitochondrion {ECO:0000313|EMBL:AEQ59312.1}.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX   NCBI_TaxID=99490 {ECO:0000313|EMBL:AEQ59312.1};
RN   [1] {ECO:0000313|EMBL:AEQ59312.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Coco {ECO:0000313|EMBL:AEQ59312.1};
RC   TISSUE=Blood {ECO:0000313|EMBL:AEQ59312.1};
RX   PubMed=22260276; DOI=10.1111/j.1365-294X.2012.05461.x;
RA   Brandt A.L., Ishida Y., Georgiadis N.J., Roca A.L.;
RT   "Forest elephant mitochondrial genomes reveal that elephantid
RT   diversification in Africa tracked climate transitions.";
RL   Mol. Ecol. 21:1175-1189(2012).
RN   [2] {ECO:0000313|EMBL:AFX94966.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=SL0001 {ECO:0000313|EMBL:AFX94966.1};
RX   PubMed=23798975; DOI=10.1111/j.1752-4571.2012.00286.x;
RA   Ishida Y., Georgiadis N.J., Hondo T., Roca A.L.;
RT   "Triangulating the provenance of African elephants using mitochondrial
RT   DNA.";
RL   Evol Appl 6:253-265(2013).
CC   -!- CATALYTIC ACTIVITY: NADH + ubiquinone + 5 H(+)(In) = NAD(+) +
CC       ubiquinol + 4 H(+)(Out). {ECO:0000256|RuleBase:RU004430}.
CC   -!- SIMILARITY: Belongs to the complex I subunit 6 family.
CC       {ECO:0000256|RuleBase:RU004429, ECO:0000256|SAAS:SAAS00585382}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; JN673264; AEQ59312.1; -; Genomic_DNA.
DR   EMBL; JQ438501; AFX94966.1; -; Genomic_DNA.
DR   RefSeq; YP_007626834.1; NC_020759.1.
DR   RefSeq; YP_007626834.1; NC_020759.1.
DR   RefSeq; YP_007626834.1; NC_020759.1.
DR   GeneID; 14842600; -.
DR   CTD; 4541; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-KW.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR   InterPro; IPR001457; NADH_UbQ/plastoQ_OxRdtase_su6.
DR   Pfam; PF00499; Oxidored_q3; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAAS:SAAS00477717, ECO:0000256|SAM:Phobius};
KW   Mitochondrion {ECO:0000256|RuleBase:RU004430,
KW   ECO:0000313|EMBL:AEQ59312.1}; NAD {ECO:0000256|SAAS:SAAS00119311};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU004429,
KW   ECO:0000256|SAAS:SAAS00119313};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00119307,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00119309,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     25     43       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     50     74       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     86    107       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    114    136       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    148    168       Helical. {ECO:0000256|SAM:Phobius}.
SQ   SEQUENCE   175 AA;  19022 MW;  8C91189B340559E9 CRC64;
     MMYIVFIMSV LYVVGFIGFS SKPSPVYGGM SLVVSGGLGC GIIMSSGGSF LGLVVFLVYL
     GGMMVVFGYT IAMATEEYPE TWGSNVVILS AFLVGLLMEI SMVMWLLSGE HELMGFYFGG
     LGGLVVLGEG GFEYVREDYS GGASLYSYGF WFLAMAGWML FVSIFIAIEV TRKRY
//