ID H6RCY6_NOCCG Unreviewed; 393 AA. AC H6RCY6; DT 18-APR-2012, integrated into UniProtKB/TrEMBL. DT 18-APR-2012, sequence version 1. DT 03-MAY-2023, entry version 47. DE RecName: Full=Cytochrome bc1 complex Rieske iron-sulfur subunit {ECO:0000256|ARBA:ARBA00015816}; DE AltName: Full=Cytochrome bc1 reductase complex subunit QcrA {ECO:0000256|ARBA:ARBA00029586}; DE AltName: Full=Rieske iron-sulfur protein {ECO:0000256|ARBA:ARBA00032409}; GN Name=qcrA {ECO:0000313|EMBL:CCF62630.1}; GN OrderedLocusNames=NOCYR_1844 {ECO:0000313|EMBL:CCF62630.1}; OS Nocardia cyriacigeorgica (strain GUH-2). OC Bacteria; Actinomycetota; Corynebacteriales; Nocardiaceae; Nocardia. OX NCBI_TaxID=1127134 {ECO:0000313|EMBL:CCF62630.1, ECO:0000313|Proteomes:UP000008190}; RN [1] {ECO:0000313|EMBL:CCF62630.1, ECO:0000313|Proteomes:UP000008190} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=GUH-2 {ECO:0000313|EMBL:CCF62630.1, RC ECO:0000313|Proteomes:UP000008190}; RX PubMed=22461543; DOI=10.1128/JB.00161-12; RA Zoropogui A., Pujic P., Normand P., Barbe V., Beaman B., Beaman L., RA Boiron P., Colinon C., Deredjian A., Graindorge A., Mangenot S., RA Nazaret S., Neto M., Petit S., Roche D., Vallenet D., Rodriguez-Nava V., RA Richard Y., Cournoyer B., Blaha D.; RT "Genome sequence of the human- and animal-pathogenic strain Nocardia RT cyriacigeorgica GUH-2."; RL J. Bacteriol. 194:2098-2099(2012). CC -!- FUNCTION: Iron-sulfur subunit of the cytochrome bc1 complex, an CC essential component of the respiratory electron transport chain CC required for ATP synthesis. The bc1 complex catalyzes the oxidation of CC menaquinol and the reduction of cytochrome c in the respiratory chain. CC The bc1 complex operates through a Q-cycle mechanism that couples CC electron transfer to generation of the proton gradient that drives ATP CC synthesis. {ECO:0000256|ARBA:ARBA00002494}. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004141}. CC -!- SIMILARITY: Belongs to the Rieske iron-sulfur protein family. CC {ECO:0000256|ARBA:ARBA00010651}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; FO082843; CCF62630.1; -; Genomic_DNA. DR AlphaFoldDB; H6RCY6; -. DR STRING; 1127134.NOCYR_1844; -. DR EnsemblBacteria; CCF62630; CCF62630; NOCYR_1844. DR KEGG; ncy:NOCYR_1844; -. DR eggNOG; COG0723; Bacteria. DR HOGENOM; CLU_050668_0_0_11; -. DR OMA; SHLGCPA; -. DR OrthoDB; 9802613at2; -. DR Proteomes; UP000008190; Chromosome. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:UniProtKB-KW. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0004497; F:monooxygenase activity; IEA:UniProt. DR GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:UniProt. DR CDD; cd03467; Rieske; 1. DR Gene3D; 2.102.10.10; Rieske [2Fe-2S] iron-sulphur domain; 1. DR InterPro; IPR045603; QcrA_N. DR InterPro; IPR017941; Rieske_2Fe-2S. DR InterPro; IPR036922; Rieske_2Fe-2S_sf. DR InterPro; IPR014349; Rieske_Fe-S_prot. DR PANTHER; PTHR10134; CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL; 1. DR PANTHER; PTHR10134:SF43; CYTOCHROME BC1 COMPLEX RIESKE IRON-SULFUR SUBUNIT; 1. DR Pfam; PF19297; QcrA_N; 1. DR Pfam; PF00355; Rieske; 1. DR SUPFAM; SSF50022; ISP domain; 1. DR PROSITE; PS51296; RIESKE; 1. PE 3: Inferred from homology; KW 2Fe-2S {ECO:0000256|ARBA:ARBA00022714}; KW Cell membrane {ECO:0000256|ARBA:ARBA00022475}; KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157}; KW Iron {ECO:0000256|ARBA:ARBA00023004}; KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}; KW Reference proteome {ECO:0000313|Proteomes:UP000008190}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 74..95 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 115..135 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 185..205 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 281..375 FT /note="Rieske" FT /evidence="ECO:0000259|PROSITE:PS51296" FT REGION 1..31 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 393 AA; 43419 MW; DF03E60B8CADBDF9 CRC64; MGRPDEGSSA EPSKETVKPT GHAAAEPTEA ELDAMSRDEL VKLGTEMDGV DVAYRRERFP VPGTRAEKRA ERQVALWFAI SGLAAAALVG VFLFWPWEYK GKESEGHDLY SLATPLYGLT FGVSILAIGI AVVLIRKKFI PAELSIQERH DGRSSEVDRR TLVAELQDAL DTSTLGRRKM ITRTAGAGLG IVGLGSAALF VGGMIKNPWA KGDKSPLWVS GWTPDWEGQT IYLRRDTGRP EDIVLVRPED LDAGGMETVF PWKEVWRGDE HATLQSLRGI RNAVMLIRLR TEDAQKAVKR KGQESFNFGD YFAYSKICTH LGCPTSLYEQ QTNRILCPCH QSQFSATEWG KPVFGPAARA LPQLPITVNS EGFLVANGDF IEPLGPAFWE RRS //