ID H6QM70_I09A8 Unreviewed; 760 AA. AC H6QM70; DT 18-APR-2012, integrated into UniProtKB/TrEMBL. DT 18-APR-2012, sequence version 1. DT 22-FEB-2023, entry version 54. DE RecName: Full=Polymerase basic protein 2 {ECO:0000256|ARBA:ARBA00014261, ECO:0000256|RuleBase:RU361246}; GN Name=PB2 {ECO:0000256|RuleBase:RU361246, ECO:0000313|EMBL:AFC35415.1}; OS Influenza A virus (strain A/little yellow-shouldered OS bat/Guatemala/153/2009(H17N10)). OC Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina; OC Insthoviricetes; Articulavirales; Orthomyxoviridae; Alphainfluenzavirus. OX NCBI_TaxID=1129345 {ECO:0000313|EMBL:AFC35415.1, ECO:0000313|Proteomes:UP000137917}; OH NCBI_TaxID=27660; Sturnira lilium (Lesser yellow-shouldered bat). RN [1] {ECO:0000313|Proteomes:UP000137917} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=22371588; DOI=10.1073/pnas.1116200109; RA Tong S., Li Y., Rivailler P., Conrardy C., Alvarez Castillo D.A., RA Chen L.-M., Recuenco S., Ellison J.A., Davis C.T., York I.A., RA Turmelle A.S., Moran D., Rogers S., Shi M., Tao Y., Weil M.R., Tang K., RA Rowe L.A., Sammons S., Xu X., Frace M., Lindblade K.A., Cox N.J., RA Anderson L.J., Rupprecht C., Donis R.O.; RT "A distinct lineage of influenza A virus from bats."; RL Proc. Natl. Acad. Sci. U.S.A. 109:4269-4274(2012). CC -!- FUNCTION: Plays an essential role in transcription initiation and cap- CC stealing mechanism, in which cellular capped pre-mRNAs are used to CC generate primers for viral transcription. CC {ECO:0000256|RuleBase:RU361246}. CC -!- SUBUNIT: Influenza RNA polymerase is composed of three subunits: PB1, CC PB2 and PA. {ECO:0000256|RuleBase:RU361246}. CC -!- SUBCELLULAR LOCATION: Host mitochondrion CC {ECO:0000256|ARBA:ARBA00004181}. Mitochondrion CC {ECO:0000256|ARBA:ARBA00004173}. Virion CC {ECO:0000256|RuleBase:RU361246}. Host nucleus CC {ECO:0000256|RuleBase:RU361246}. CC -!- SIMILARITY: Belongs to the influenza viruses PB2 family. CC {ECO:0000256|ARBA:ARBA00008660, ECO:0000256|RuleBase:RU361246}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CY103873; AFC35415.1; -; Viral_cRNA. DR Proteomes; UP000137917; Genome. DR GO; GO:0033650; C:host cell mitochondrion; IEA:UniProtKB-SubCell. DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0044423; C:virion component; IEA:UniProtKB-KW. DR GO; GO:0003723; F:RNA binding; IEA:InterPro. DR GO; GO:0006370; P:7-methylguanosine mRNA capping; IEA:UniProtKB-KW. DR GO; GO:0075526; P:cap snatching; IEA:UniProtKB-KW. DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro. DR GO; GO:0039523; P:suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity; IEA:UniProtKB-KW. DR GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro. DR Gene3D; 3.30.30.90; Polymerase Basic Protein 2, C-terminal domain; 1. DR InterPro; IPR001591; INV_PB2. DR InterPro; IPR037258; PDB2_C. DR Pfam; PF00604; Flu_PB2; 1. DR SUPFAM; SSF160453; PB2 C-terminal domain-like; 1. PE 3: Inferred from homology; KW Cap snatching {ECO:0000256|ARBA:ARBA00022715}; KW Eukaryotic host gene expression shutoff by virus KW {ECO:0000256|ARBA:ARBA00023103}; KW Eukaryotic host transcription shutoff by virus KW {ECO:0000256|ARBA:ARBA00022731}; KW Host gene expression shutoff by virus {ECO:0000256|ARBA:ARBA00023103}; KW Host nucleus {ECO:0000256|ARBA:ARBA00022562, KW ECO:0000256|RuleBase:RU361246}; KW Host-virus interaction {ECO:0000256|ARBA:ARBA00023103}; KW Inhibition of host RNA polymerase II by virus KW {ECO:0000256|ARBA:ARBA00023103}; KW mRNA capping {ECO:0000256|ARBA:ARBA00023042, KW ECO:0000256|RuleBase:RU361246}; KW mRNA processing {ECO:0000256|ARBA:ARBA00022664, KW ECO:0000256|RuleBase:RU361246}; KW Reference proteome {ECO:0000313|Proteomes:UP000137917}; KW Viral transcription {ECO:0000256|ARBA:ARBA00023314}; KW Virion {ECO:0000256|RuleBase:RU361246}. SQ SEQUENCE 760 AA; 86170 MW; C76EECE28F993DDB CRC64; MERIKELLEM VKNSRMREIL TTTSVDHMAV IKKYTSGRQE KNPALRMKWM MAMKYPISAS SRIREMIPEK DEDGNTLWTN TKDAGSNRVL VSPNAVTWWN RAGPVSDVVH YPRVYKMYFD RLERLTHGTF GPVKFYNQVK VRKRVDINPG HKDLTSREAQ EVIMEVVFPN EVGARTLSSD AQLTITKEKK EELKNCKISP IMVAYMLERE LVRRTRFLPI AGATSSTYVE VLHLTQGTCW EQQYTPGGEA ENDDLDQTLI IASRNIVRRS IVAIDPLASL LSMCHTTSIS SEPLVEILRS NPTDEQAVNI CKAALGIRIN NSFSFGGYNF KRVKGSSQRT EKAVLTGNLQ TLTMTIFEGY EEFNVSGKRA SAVLKKGTQR LIQAIIGGRT LEDILNLMIT LMVFSQEEKM LKAVRGDLNF VNRANQRLNP MYQLLRHFQK DSSTLLRNWG TEEIDPIMGI AGIMPDGTIN KNQTLIGVRL SQGGVDEYSF NERIRVNIDK YLRVRNEKGE LLISPEEVSE AQGQEKLPIN YNSSLMWEVN GPESILTNTY HWIIKNWELL KTQWMTDPTV LYNRMEFEPF QTLIPKGNRA TYSGFTRTLF QQMRDVEGTF DSIQVIKLLP FSAHPPSLGR TQFSSFTLNI RGAPLRLLIR GNSQVFNYNQ MENVIIVLGK SVGSPERSIL TESSSIESAV LRGFLILGKA NSKYGPVLTI GELDKLGRGE KANVLIGQGD TVLVMKRKRD SSILTDSQTA LKRIRLEESK //