ID H6QM70_I09A8 Unreviewed; 760 AA. AC H6QM70; DT 18-APR-2012, integrated into UniProtKB/TrEMBL. DT 18-APR-2012, sequence version 1. DT 05-JUN-2019, entry version 36. DE RecName: Full=Polymerase basic protein 2 {ECO:0000256|RuleBase:RU361246, ECO:0000256|SAAS:SAAS00943514}; GN Name=PB2 {ECO:0000256|RuleBase:RU361246, ECO:0000313|EMBL:AFC35415.1}; OS Influenza A virus (strain A/little yellow-shouldered OS bat/Guatemala/153/2009(H17N10)). OC Viruses; Riboviria; Negarnaviricota; Polyploviricotina; OC Insthoviricetes; Articulavirales; Orthomyxoviridae; OC Alphainfluenzavirus. OX NCBI_TaxID=1129345 {ECO:0000313|EMBL:AFC35415.1, ECO:0000313|Proteomes:UP000137917}; RN [1] {ECO:0000313|Proteomes:UP000137917} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=22371588; DOI=10.1073/pnas.1116200109; RA Tong S., Li Y., Rivailler P., Conrardy C., Alvarez Castillo D.A., RA Chen L.-M., Recuenco S., Ellison J.A., Davis C.T., York I.A., RA Turmelle A.S., Moran D., Rogers S., Shi M., Tao Y., Weil M.R., RA Tang K., Rowe L.A., Sammons S., Xu X., Frace M., Lindblade K.A., RA Cox N.J., Anderson L.J., Rupprecht C., Donis R.O.; RT "A distinct lineage of influenza A virus from bats."; RL Proc. Natl. Acad. Sci. U.S.A. 109:4269-4274(2012). CC -!- FUNCTION: Plays an essential role in transcription initiation and CC cap-stealing mechanism, in which cellular capped pre-mRNAs are CC used to generate primers for viral transcription. CC {ECO:0000256|RuleBase:RU361246}. CC -!- SUBUNIT: Influenza RNA polymerase is composed of three subunits: CC PB1, PB2 and PA. {ECO:0000256|RuleBase:RU361246}. CC -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000256|RuleBase:RU361246, CC ECO:0000256|SAAS:SAAS00943502}. Virion CC {ECO:0000256|RuleBase:RU361246}. CC -!- SIMILARITY: Belongs to the influenza viruses PB2 family. CC {ECO:0000256|RuleBase:RU361246, ECO:0000256|SAAS:SAAS00943527}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CY103873; AFC35415.1; -; Viral_cRNA. DR Proteomes; UP000137917; Genome. DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0019012; C:virion; IEA:UniProtKB-SubCell. DR GO; GO:0003723; F:RNA binding; IEA:InterPro. DR GO; GO:0006370; P:7-methylguanosine mRNA capping; IEA:UniProtKB-KW. DR GO; GO:0075526; P:cap snatching; IEA:UniProtKB-KW. DR GO; GO:0039523; P:suppression by virus of host RNA polymerase II activity; IEA:UniProtKB-KW. DR GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro. DR GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro. DR Gene3D; 3.30.30.90; -; 1. DR InterPro; IPR001591; INV_PB2. DR InterPro; IPR037258; PDB2_C. DR Pfam; PF00604; Flu_PB2; 1. DR ProDom; PD001667; RNA_pol_PB2_orthomyxovir; 1. DR SUPFAM; SSF160453; SSF160453; 1. PE 3: Inferred from homology; KW Cap snatching {ECO:0000256|SAAS:SAAS00943529}; KW Complete proteome {ECO:0000313|Proteomes:UP000137917}; KW Eukaryotic host gene expression shutoff by virus KW {ECO:0000256|SAAS:SAAS00943497}; KW Eukaryotic host transcription shutoff by virus KW {ECO:0000256|SAAS:SAAS00943528}; KW Host gene expression shutoff by virus {ECO:0000256|SAAS:SAAS00943501}; KW Host nucleus {ECO:0000256|RuleBase:RU361246, KW ECO:0000256|SAAS:SAAS00943496}; KW Host-virus interaction {ECO:0000256|SAAS:SAAS00943506}; KW Inhibition of host RNA polymerase II by virus KW {ECO:0000256|SAAS:SAAS00943508}; KW mRNA capping {ECO:0000256|RuleBase:RU361246, KW ECO:0000256|SAAS:SAAS00943498}; KW mRNA processing {ECO:0000256|RuleBase:RU361246, KW ECO:0000256|SAAS:SAAS00943500}; KW Reference proteome {ECO:0000313|Proteomes:UP000137917}; KW Viral transcription {ECO:0000256|SAAS:SAAS00943507}; KW Virion {ECO:0000256|RuleBase:RU361246, ECO:0000256|SAAS:SAAS00943495}. SQ SEQUENCE 760 AA; 86170 MW; C76EECE28F993DDB CRC64; MERIKELLEM VKNSRMREIL TTTSVDHMAV IKKYTSGRQE KNPALRMKWM MAMKYPISAS SRIREMIPEK DEDGNTLWTN TKDAGSNRVL VSPNAVTWWN RAGPVSDVVH YPRVYKMYFD RLERLTHGTF GPVKFYNQVK VRKRVDINPG HKDLTSREAQ EVIMEVVFPN EVGARTLSSD AQLTITKEKK EELKNCKISP IMVAYMLERE LVRRTRFLPI AGATSSTYVE VLHLTQGTCW EQQYTPGGEA ENDDLDQTLI IASRNIVRRS IVAIDPLASL LSMCHTTSIS SEPLVEILRS NPTDEQAVNI CKAALGIRIN NSFSFGGYNF KRVKGSSQRT EKAVLTGNLQ TLTMTIFEGY EEFNVSGKRA SAVLKKGTQR LIQAIIGGRT LEDILNLMIT LMVFSQEEKM LKAVRGDLNF VNRANQRLNP MYQLLRHFQK DSSTLLRNWG TEEIDPIMGI AGIMPDGTIN KNQTLIGVRL SQGGVDEYSF NERIRVNIDK YLRVRNEKGE LLISPEEVSE AQGQEKLPIN YNSSLMWEVN GPESILTNTY HWIIKNWELL KTQWMTDPTV LYNRMEFEPF QTLIPKGNRA TYSGFTRTLF QQMRDVEGTF DSIQVIKLLP FSAHPPSLGR TQFSSFTLNI RGAPLRLLIR GNSQVFNYNQ MENVIIVLGK SVGSPERSIL TESSSIESAV LRGFLILGKA NSKYGPVLTI GELDKLGRGE KANVLIGQGD TVLVMKRKRD SSILTDSQTA LKRIRLEESK //