ID H6QM70_9INFA Unreviewed; 760 AA. AC H6QM70; DT 18-APR-2012, integrated into UniProtKB/TrEMBL. DT 18-APR-2012, sequence version 1. DT 08-JUN-2016, entry version 18. DE RecName: Full=Polymerase basic protein 2 {ECO:0000256|RuleBase:RU361246, ECO:0000256|SAAS:SAAS00118352}; GN Name=PB2 {ECO:0000256|RuleBase:RU361246, ECO:0000313|EMBL:AFC35415.1}; OS Influenza A virus (A/little yellow-shouldered OS bat/Guatemala/153/2009(H17N10)). OC Viruses; ssRNA viruses; ssRNA negative-strand viruses; OC Orthomyxoviridae; Influenzavirus A. OX NCBI_TaxID=1129345 {ECO:0000313|EMBL:AFC35415.1}; RN [1] {ECO:0000313|EMBL:AFC35415.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=A/little yellow-shouldered bat/Guatemala/153/2009 RC {ECO:0000313|EMBL:AFC35415.1}; RA Tong S., Li Y., Rivailler P., Conrardy C., Alvarez Castillo D.A., RA Chen L.-M., Recuenco S., Ellison J.A., Davis C.T., York I.A., RA Turmelle A.S., Moran D., Rogers S., Shi M., Tao Y., Weil M.R., RA Tang K., Rowe L.A., Sammons S., Xu X., Frace M., Lindblade K.A., RA Cox N.J., Anderson L.J., Rupprecht C., Donis R.O.; RT "A distinct lineage of influenza A virus from bats."; RL Proc. Natl. Acad. Sci. U.S.A. 0:0-0(2012). CC -!- FUNCTION: Plays an essential role in transcription initiation and CC cap-stealing mechanism, in which cellular capped pre-mRNAs are CC used to generate primers for viral transcription. CC {ECO:0000256|RuleBase:RU361246}. CC -!- FUNCTION: Plays an essential role in transcription initiation and CC cap-stealing mechanism, in which cellular capped pre-mRNAs are CC used to generate primers for viral transcription. Binds the cap of CC the target pre-RNA which is subsequently cleaved after 10-13 CC nucleotides by PA. Plays a role in the initiation of the viral CC genome replication and modulates the activity of the CC ribonucleoprotein (RNP) complex. In addition, participates in the CC inhibition of type I interferon induction through interaction with CC the host mitochondrial antiviral signaling protein MAVS. CC {ECO:0000256|SAAS:SAAS00161294}. CC -!- SUBUNIT: Influenza RNA polymerase is composed of three subunits: CC PB1, PB2 and PA. {ECO:0000256|RuleBase:RU361246, CC ECO:0000256|SAAS:SAAS00118334}. CC -!- SUBUNIT: Influenza RNA polymerase is composed of three subunits: CC PB1, PB2 and PA. Interacts (via N-terminus) with PB1 (via C- CC terminus). Interacts with nucleoprotein NP (via N-terminus). CC Interacts (via N-terminus) with host MAVS (via N-terminus); this CC interaction inhibits host innate immune response. CC {ECO:0000256|SAAS:SAAS00161291}. CC -!- SUBCELLULAR LOCATION: Virion {ECO:0000256|RuleBase:RU361246}. Host CC nucleus {ECO:0000256|RuleBase:RU361246}. Host mitochondrion CC {ECO:0000256|RuleBase:RU361246}. CC -!- SIMILARITY: Belongs to the influenza viruses PB2 family. CC {ECO:0000256|RuleBase:RU361246, ECO:0000256|SAAS:SAAS00584119}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CY103873; AFC35415.1; -; Viral_cRNA. DR GO; GO:0033650; C:host cell mitochondrion; IEA:UniProtKB-SubCell. DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0019012; C:virion; IEA:UniProtKB-SubCell. DR GO; GO:0003723; F:RNA binding; IEA:InterPro. DR GO; GO:0003968; F:RNA-directed RNA polymerase activity; IEA:InterPro. DR GO; GO:0006370; P:7-methylguanosine mRNA capping; IEA:UniProtKB-KW. DR GO; GO:0075526; P:cap snatching; IEA:UniProtKB-KW. DR GO; GO:0039545; P:suppression by virus of host MAVS activity; IEA:UniProtKB-KW. DR GO; GO:0039523; P:suppression by virus of host RNA polymerase II activity; IEA:UniProtKB-KW. DR GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro. DR InterPro; IPR001591; RNA_pol_PB2_orthomyxovir. DR Pfam; PF00604; Flu_PB2; 1. DR ProDom; PD001667; RNA_pol_PB2_orthomyxovir; 1. PE 3: Inferred from homology; KW Cap snatching {ECO:0000256|SAAS:SAAS00477284}; KW Eukaryotic host gene expression shutoff by virus KW {ECO:0000256|SAAS:SAAS00477208}; KW Eukaryotic host transcription shutoff by virus KW {ECO:0000256|SAAS:SAAS00477383}; KW Host gene expression shutoff by virus {ECO:0000256|SAAS:SAAS00477173}; KW Host mitochondrion {ECO:0000256|RuleBase:RU361246}; KW Host nucleus {ECO:0000256|RuleBase:RU361246}; KW Host-virus interaction {ECO:0000256|SAAS:SAAS00477422}; KW Inhibition of host innate immune response by virus KW {ECO:0000256|SAAS:SAAS00477452}; KW Inhibition of host MAVS by virus {ECO:0000256|SAAS:SAAS00477114}; KW Inhibition of host RLR pathway by virus KW {ECO:0000256|SAAS:SAAS00477196}; KW Inhibition of host RNA polymerase II by virus KW {ECO:0000256|SAAS:SAAS00477256}; KW mRNA capping {ECO:0000256|RuleBase:RU361246, KW ECO:0000256|SAAS:SAAS00477228}; KW mRNA processing {ECO:0000256|RuleBase:RU361246, KW ECO:0000256|SAAS:SAAS00476958}; KW Viral immunoevasion {ECO:0000256|SAAS:SAAS00477196}; KW Viral transcription {ECO:0000256|SAAS:SAAS00477398}; KW Virion {ECO:0000256|RuleBase:RU361246}. SQ SEQUENCE 760 AA; 86170 MW; C76EECE28F993DDB CRC64; MERIKELLEM VKNSRMREIL TTTSVDHMAV IKKYTSGRQE KNPALRMKWM MAMKYPISAS SRIREMIPEK DEDGNTLWTN TKDAGSNRVL VSPNAVTWWN RAGPVSDVVH YPRVYKMYFD RLERLTHGTF GPVKFYNQVK VRKRVDINPG HKDLTSREAQ EVIMEVVFPN EVGARTLSSD AQLTITKEKK EELKNCKISP IMVAYMLERE LVRRTRFLPI AGATSSTYVE VLHLTQGTCW EQQYTPGGEA ENDDLDQTLI IASRNIVRRS IVAIDPLASL LSMCHTTSIS SEPLVEILRS NPTDEQAVNI CKAALGIRIN NSFSFGGYNF KRVKGSSQRT EKAVLTGNLQ TLTMTIFEGY EEFNVSGKRA SAVLKKGTQR LIQAIIGGRT LEDILNLMIT LMVFSQEEKM LKAVRGDLNF VNRANQRLNP MYQLLRHFQK DSSTLLRNWG TEEIDPIMGI AGIMPDGTIN KNQTLIGVRL SQGGVDEYSF NERIRVNIDK YLRVRNEKGE LLISPEEVSE AQGQEKLPIN YNSSLMWEVN GPESILTNTY HWIIKNWELL KTQWMTDPTV LYNRMEFEPF QTLIPKGNRA TYSGFTRTLF QQMRDVEGTF DSIQVIKLLP FSAHPPSLGR TQFSSFTLNI RGAPLRLLIR GNSQVFNYNQ MENVIIVLGK SVGSPERSIL TESSSIESAV LRGFLILGKA NSKYGPVLTI GELDKLGRGE KANVLIGQGD TVLVMKRKRD SSILTDSQTA LKRIRLEESK //