ID   H6NUC3_SALTI            Unreviewed;       320 AA.
AC   H6NUC3;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   03-APR-2013, entry version 9.
DE   RecName: Full=6-phosphofructokinase;
DE            Short=Phosphofructokinase;
DE            EC=2.7.1.11;
DE   AltName: Full=Phosphohexokinase;
GN   Name=pfkA; ORFNames=STBHUCCB_37400;
OS   Salmonella enterica subsp. enterica serovar Typhi str. P-stx-12.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=1132507;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=P-stx-12;
RX   PubMed=22461552; DOI=10.1128/JB.00121-12;
RA   Ong S.Y., Pratap C.B., Wan X., Hou S., Abdul Rahman A.Y., Saito J.A.,
RA   Nath G., Alam M.;
RT   "Complete Genome Sequence of Salmonella enterica subsp. enterica
RT   Serovar Typhi P-stx-12.";
RL   J. Bacteriol. 194:2115-2116(2012).
CC   -!- CATALYTIC ACTIVITY: ATP + D-fructose 6-phosphate = ADP + D-
CC       fructose 1,6-bisphosphate.
CC   -!- PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-
CC       phosphate and glycerone phosphate from D-glucose: step 3/4.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the phosphofructokinase family.
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DR   EMBL; CP003278; AEZ47351.1; -; Genomic_DNA.
DR   RefSeq; YP_005219204.1; NC_016832.1.
DR   ProteinModelPortal; H6NUC3; -.
DR   SMR; H6NUC3; 1-320.
DR   PRIDE; H6NUC3; -.
DR   EnsemblBacteria; AEZ47351; AEZ47351; STBHUCCB_37400.
DR   GeneID; 11822247; -.
DR   KEGG; sex:STBHUCCB_37400; -.
DR   KO; K00850; -.
DR   OMA; EFKTVEG; -.
DR   UniPathway; UPA00109; UER00182.
DR   GO; GO:0005945; C:6-phosphofructokinase complex; IEA:InterPro.
DR   GO; GO:0003872; F:6-phosphofructokinase activity; IEA:HAMAP.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006002; P:fructose 6-phosphate metabolic process; IEA:InterPro.
DR   GO; GO:0006096; P:glycolysis; IEA:HAMAP.
DR   HAMAP; MF_00339; Phosphofructokinase; 1; -.
DR   InterPro; IPR012003; ATP_PFK_prok.
DR   InterPro; IPR012828; PFKA_ATP.
DR   InterPro; IPR022953; Phosphofructokinase.
DR   InterPro; IPR015912; Phosphofructokinase_CS.
DR   InterPro; IPR000023; Phosphofructokinase_dom.
DR   Pfam; PF00365; PFK; 1.
DR   PIRSF; PIRSF000532; ATP_PFK_prok; 1.
DR   PRINTS; PR00476; PHFRCTKINASE.
DR   SUPFAM; SSF53784; Ppfruckinase; 1.
DR   TIGRFAMs; TIGR02482; PFKA_ATP; 1.
DR   PROSITE; PS00433; PHOSPHOFRUCTOKINASE; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; Glycolysis; Kinase; Magnesium; Metal-binding;
KW   Nucleotide-binding; Transferase.
FT   NP_BIND      22     26       ATP (By similarity).
FT   NP_BIND     155    159       ATP (By similarity).
FT   NP_BIND     172    188       ATP (By similarity).
FT   ACT_SITE    128    128       Proton acceptor (By similarity).
FT   METAL       186    186       Magnesium; via carbonyl oxygen (By
FT                                similarity).
FT   METAL       188    188       Magnesium (By similarity).
FT   BINDING     163    163       Substrate (By similarity).
FT   BINDING     244    244       Substrate (By similarity).
FT   BINDING     250    250       Substrate (By similarity).
FT   BINDING     253    253       Substrate (By similarity).
SQ   SEQUENCE   320 AA;  34915 MW;  68B0DDFCF689F420 CRC64;
     MIKKIGVLTS GGDAPGMNAA IRGVVRAALT EGLEVMGIYD GYLGLYEDRM VQLDRYSVSD
     MINRGGTFLG SARFPEFRDE NIRAVAIENL KKRGIDALVV IGGDGSYMGA KRLTEMGFPC
     IGLPGTIDND IKGTDYTIGY FTALGTVVEA IDRLRDTSSS HQRISIVEVM GRYCGDLTLA
     AAIAGGCEFI VVPEVEFNRE DLVAEIKAGI AKGKKHAIVA ITEHMCDVDE LAHFIEKETG
     RETRATVLGH IQRGGSPVPY DRILASRMGA YAIDLLLEGH GGRCVGIQNE QLVHHDIIDA
     IENMKRPFKS DWMECAKKLY
//