ID H3K3T4_HBV Unreviewed; 400 AA. AC H3K3T4; DT 18-APR-2012, integrated into UniProtKB/TrEMBL. DT 18-APR-2012, sequence version 1. DT 30-AUG-2017, entry version 23. DE RecName: Full=Large envelope protein {ECO:0000256|RuleBase:RU003356}; GN Name=S {ECO:0000313|EMBL:BAL61060.1}; OS Hepatitis B virus (HBV). OC Viruses; Retro-transcribing viruses; Hepadnaviridae; OC Orthohepadnavirus. OX NCBI_TaxID=10407 {ECO:0000313|EMBL:BAL61060.1, ECO:0000313|Proteomes:UP000120227}; OH NCBI_TaxID=9598; Pan troglodytes (Chimpanzee). OH NCBI_TaxID=9606; Homo sapiens (Human). RN [1] {ECO:0000313|Proteomes:UP000120227} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21248087; DOI=10.1128/JCM.02149-10; RA Fujisaki S., Yokomaku Y., Shiino T., Koibuchi T., Hattori J., Ibe S., RA Iwatani Y., Iwamoto A., Shirasaka T., Hamaguchi M., Sugiura W.; RT "Outbreak of infections by hepatitis B virus genotype A and RT transmission of genetic drug resistance in patients coinfected with RT HIV-1 in Japan."; RL J. Clin. Microbiol. 49:1017-1024(2011). CC -!- FUNCTION: The large envelope protein exists in two topological CC conformations, one which is termed 'external' or Le-HBsAg and the CC other 'internal' or Li-HBsAg. In its external conformation the CC protein attaches the virus to cell receptors and thereby CC initiating infection. This interaction determines the species CC specificity and liver tropism. This attachment induces virion CC internalization predominantly through caveolin-mediated CC endocytosis. The large envelope protein also assures fusion CC between virion membrane and endosomal membrane. In its internal CC conformation the protein plays a role in virion morphogenesis and CC mediates the contact with the nucleocapsid like a matrix protein. CC {ECO:0000256|SAAS:SAAS00857669}. CC -!- FUNCTION: The middle envelope protein plays an important role in CC the budding of the virion. It is involved in the induction of CC budding in a nucleocapsid independent way. In this process the CC majority of envelope proteins bud to form subviral lipoprotein CC particles of 22 nm of diameter that do not contain a nucleocapsid. CC {ECO:0000256|SAAS:SAAS00796594}. CC -!- SUBUNIT: Li-HBsAg interacts with capsid protein and with HDV Large CC delta antigen. Isoform M associates with host chaperone CANX CC through its pre-S2 N glycan. This association may be essential for CC M proper secretion. {ECO:0000256|SAAS:SAAS00857670}. CC -!- SUBCELLULAR LOCATION: Virion membrane CC {ECO:0000256|SAAS:SAAS00410337}. CC -!- SIMILARITY: Belongs to the orthohepadnavirus major surface antigen CC family. {ECO:0000256|SAAS:SAAS00796655}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB697509; BAL61060.1; -; Genomic_DNA. DR Proteomes; UP000120227; Genome. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell. DR GO; GO:0039663; P:membrane fusion involved in viral entry into host cell; IEA:UniProtKB-KW. DR GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW. DR InterPro; IPR000349; Hepvir_surfAg. DR Pfam; PF00695; vMSA; 1. PE 3: Inferred from homology; KW Caveolin-mediated endocytosis of virus by host KW {ECO:0000256|SAAS:SAAS00857673}; KW Complete proteome {ECO:0000313|Proteomes:UP000120227}; KW Fusion of virus membrane with host endosomal membrane KW {ECO:0000256|SAAS:SAAS00857671}; KW Fusion of virus membrane with host membrane KW {ECO:0000256|SAAS:SAAS00138109}; KW Host-virus interaction {ECO:0000256|SAAS:SAAS00489060}; KW Membrane {ECO:0000256|SAAS:SAAS00489153, ECO:0000256|SAM:Phobius}; KW Transmembrane {ECO:0000256|SAAS:SAAS00138120, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00489144, KW ECO:0000256|SAM:Phobius}; KW Viral attachment to host cell {ECO:0000256|SAAS:SAAS00138246}; KW Viral penetration into host cytoplasm {ECO:0000256|SAAS:SAAS00489049}; KW Virion {ECO:0000256|SAAS:SAAS00138122}; KW Virus endocytosis by host {ECO:0000256|SAAS:SAAS00857668}; KW Virus entry into host cell {ECO:0000256|SAAS:SAAS00489175}. FT TRANSMEM 182 200 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 254 272 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 344 373 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 379 399 Helical. {ECO:0000256|SAM:Phobius}. SQ SEQUENCE 400 AA; 43660 MW; 39B6FE555744DB6F CRC64; MGGWSSKPRK GMGTNLSVPN PLGFFPDHQL DPAFGANSNN PDWDFKPIKD HWPAANQVGV GAFGPGLTPP HGGILGWSPQ AQGILTTVST IPPPASTNRQ SGRQPTPISP PLRDSHPQAM QWNSTAFHQA LQDPRVRGLY FPAGGSSSGT VNPAPNIASH ISSISARTGD PVTNMENITS GFLGPLLVLQ AGFFLLTRIL TIPQSLDSWW TSLNFLGGSP VCLGQNSQSP TSNHSPTSCP PICPGYRWMC LRRFIIFLFI LLLCLIFLLV LLDYQGMLPV CPLIPGSTTT STGPCKTCTT PAQGNSMFPS CCCTKPTDGN CTCIPIPSSW AFAKYLWEWA SVRFSWLSLL VPFVQWFVGL SPTVWLSAIW MMWYWGPSLY SIVSPFIPLL PIFFCLWVYI //