ID H3K3T4_HBV Unreviewed; 400 AA. AC H3K3T4; DT 18-APR-2012, integrated into UniProtKB/TrEMBL. DT 18-APR-2012, sequence version 1. DT 16-APR-2014, entry version 10. DE RecName: Full=Large envelope protein; GN Name=S; OS Hepatitis B virus (HBV). OC Viruses; Retro-transcribing viruses; Hepadnaviridae; OC Orthohepadnavirus. OX NCBI_TaxID=10407; OH NCBI_TaxID=9606; Homo sapiens (Human). OH NCBI_TaxID=9598; Pan troglodytes (Chimpanzee). RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=No32; RA Fujisaki S., Yokomaku Y., Shiino T., Koibuchi T., Hattori J., Ibe S., RA Iwatani Y., Iwamoto A., Shirasaka T., Hamaguchi M., Sugiura W.; RT "Outbreak of Infections by Hepatitis B Virus Genotype A and RT Transmission of Genetic Drug Resistance in Patients Coinfected with RT HIV-1 in Japan."; RL J. Clin. Microbiol. 49:1017-1024(2011). RN [2] RP NUCLEOTIDE SEQUENCE. RC STRAIN=No32; RA Fujisaki S., Yokomaku Y., Hattori J., Ibe S., Iwatani Y., RA Hamaguchi M., Sugiura W.; RL Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: The middle envelope protein plays an important role in CC the budding of the virion. It is involved in the induction of CC budding in a nucleocapsid independent way. In this process the CC majority of envelope proteins bud to form subviral lipoprotein CC particles of 22 nm of diameter that do not contain a nucleocapsid CC (By similarity). CC -!- SUBCELLULAR LOCATION: Virion membrane (By similarity). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB697509; BAL61060.1; -; Genomic_DNA. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell. DR GO; GO:0039663; P:membrane fusion involved in viral entry into host cell; IEA:UniProtKB-KW. DR GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW. DR InterPro; IPR000349; Hepvir_surfAg. DR Pfam; PF00695; vMSA; 1. PE 3: Inferred from homology; KW Fusion of virus membrane with host membrane; Host-virus interaction; KW Membrane; Transmembrane; Transmembrane helix; KW Viral attachment to host cell; Viral penetration into host cytoplasm; KW Virion; Virus entry into host cell. SQ SEQUENCE 400 AA; 43660 MW; 39B6FE555744DB6F CRC64; MGGWSSKPRK GMGTNLSVPN PLGFFPDHQL DPAFGANSNN PDWDFKPIKD HWPAANQVGV GAFGPGLTPP HGGILGWSPQ AQGILTTVST IPPPASTNRQ SGRQPTPISP PLRDSHPQAM QWNSTAFHQA LQDPRVRGLY FPAGGSSSGT VNPAPNIASH ISSISARTGD PVTNMENITS GFLGPLLVLQ AGFFLLTRIL TIPQSLDSWW TSLNFLGGSP VCLGQNSQSP TSNHSPTSCP PICPGYRWMC LRRFIIFLFI LLLCLIFLLV LLDYQGMLPV CPLIPGSTTT STGPCKTCTT PAQGNSMFPS CCCTKPTDGN CTCIPIPSSW AFAKYLWEWA SVRFSWLSLL VPFVQWFVGL SPTVWLSAIW MMWYWGPSLY SIVSPFIPLL PIFFCLWVYI //