ID H3HXK0_STRPU Unreviewed; 380 AA. AC H3HXK0; DT 18-APR-2012, integrated into UniProtKB/TrEMBL. DT 18-APR-2012, sequence version 1. DT 22-FEB-2023, entry version 54. DE SubName: Full=Sialidase NEU1.3 {ECO:0000313|EMBL:DAA35227.1}; DE Flags: Fragment; OS Strongylocentrotus purpuratus (Purple sea urchin). OC Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Echinoidea; OC Euechinoidea; Echinacea; Camarodonta; Echinidea; Strongylocentrotidae; OC Strongylocentrotus. OX NCBI_TaxID=7668 {ECO:0000313|EMBL:DAA35227.1}; RN [1] {ECO:0000313|EMBL:DAA35227.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=10191093; DOI=10.1006/geno.1999.5749; RA Monti E., Preti A., Rossi E., Ballabio A., Borsani G.; RT "Cloning and characterization of NEU2, a human gene homologous to rodent RT soluble sialidases."; RL Genomics 57:137-143(1999). RN [2] {ECO:0000313|EMBL:DAA35227.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=10861246; DOI=10.1042/0264-6021:3490343; RA Monti E., Bassi M.T., Papini N., Riboni M., Manzoni M., Venerando B., RA Croci G., Preti A., Ballabio A., Tettamanti G., Borsani G.; RT "Identification and expression of NEU3, a novel human sialidase associated RT to the plasma membrane."; RL Biochem. J. 349:343-351(2000). RN [3] {ECO:0000313|EMBL:DAA35227.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=14962670; DOI=10.1016/j.ygeno.2003.08.019; RA Monti E., Bassi M.T., Bresciani R., Civini S., Croci G.L., Papini N., RA Riboni M., Zanchetti G., Ballabio A., Preti A., Tettamanti G., RA Venerando B., Borsani G.; RT "Molecular cloning and characterization of NEU4, the fourth member of the RT human sialidase gene family."; RL Genomics 83:445-453(2004). RN [4] {ECO:0000313|EMBL:DAA35227.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=17708749; DOI=10.1042/BJ20070627; RA Manzoni M., Colombi P., Papini N., Rubaga L., Tiso N., Preti A., RA Venerando B., Tettamanti G., Bresciani R., Argenton F., Borsani G., RA Monti E.; RT "Molecular cloning and biochemical characterization of sialidases from RT zebrafish (Danio rerio)."; RL Biochem. J. 408:395-406(2007). RN [5] {ECO:0000313|EMBL:DAA35227.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=21861893; DOI=10.1186/1471-2091-12-45; RA Giacopuzzi E., Barlati S., Preti A., Venerando B., Monti E., Borsani G., RA Bresciani R.; RT "Gallus gallus NEU3 sialidase as model to study protein evolution mechanism RT based on rapid evolving loops."; RL BMC Biochem. 12:45-45(2011). RN [6] {ECO:0000313|EMBL:DAA35227.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=22952925; DOI=10.1371/journal.pone.0044193; RA Giacopuzzi E., Bresciani R., Schauer R., Monti E., Borsani G.; RT "New insights on the sialidase protein family revealed by a phylogenetic RT analysis in metazoa."; RL PLoS ONE 7:E44193-E44193(2012). CC -!- MISCELLANEOUS: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ third party annotation (TPA) entry. CC {ECO:0000313|EMBL:DAA35227.1}. CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 33 family. CC {ECO:0000256|ARBA:ARBA00009348}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BK008540; DAA35227.1; -; mRNA. DR RefSeq; XP_003724953.2; XM_003724905.2. DR AlphaFoldDB; H3HXK0; -. DR STRING; 7668.SPU_006441-tr; -. DR GeneID; 100890097; -. DR KEGG; spu:100890097; -. DR eggNOG; ENOG502QSIT; Eukaryota. DR HOGENOM; CLU_024620_3_0_1; -. DR InParanoid; H3HXK0; -. DR OrthoDB; 5388454at2759; -. DR PhylomeDB; H3HXK0; -. DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central. DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central. DR GO; GO:0005764; C:lysosome; IBA:GO_Central. DR GO; GO:0016020; C:membrane; IBA:GO_Central. DR GO; GO:0004308; F:exo-alpha-sialidase activity; IBA:GO_Central. DR GO; GO:0006689; P:ganglioside catabolic process; IBA:GO_Central. DR GO; GO:0009313; P:oligosaccharide catabolic process; IBA:GO_Central. DR CDD; cd15482; Sialidase_non-viral; 1. DR Gene3D; 2.120.10.10; -; 1. DR InterPro; IPR011040; Sialidase. DR InterPro; IPR026856; Sialidase_fam. DR InterPro; IPR036278; Sialidase_sf. DR PANTHER; PTHR10628; SIALIDASE; 1. DR PANTHER; PTHR10628:SF25; SIALIDASE-1; 1. DR Pfam; PF13088; BNR_2; 1. DR SUPFAM; SSF50939; Sialidases; 1. PE 2: Evidence at transcript level; FT DOMAIN 58..352 FT /note="Sialidase" FT /evidence="ECO:0000259|Pfam:PF13088" FT NON_TER 380 FT /evidence="ECO:0000313|EMBL:DAA35227.1" SQ SEQUENCE 380 AA; 41869 MW; 97E76FDB6B6A905C CRC64; MAKLTVQQSL LLTISSILVS VTYSINPFVL EEQLIWESSD EGEVSTYRIP IIIQVPNGDL LAFSEARKYS AADAGAKFIA MRRSSNGGQS WGENTFILND YKIPDGLNLG TVLVDSVTNS TILIHTFCVH SVCNGTGEKP SGVFMVTSSN FGYTWSDPVN LAEKNPELMD LHFDPGPGYG IQKKHPPHKG RLVTCGHGPD AEVRSMYCLH SDDGGITWHL SLGLAGLPFA ETKKTGDFVP GEVQIVELKN GTILANVRNT YSFHCNCRIQ ALSFDGGSTF PMTSMRMKQE LIDPNVCGSL LNFNDNQILF FSNPFNAGSR VNLTLHWSLD AGNTYPNLMN IYEKGSAYSC LTYIDENHIG LVYEKDNISS ISYVRIQLNL //