ID H3BPH4_HUMAN Unreviewed; 142 AA. AC H3BPH4; DT 18-APR-2012, integrated into UniProtKB/TrEMBL. DT 18-APR-2012, sequence version 1. DT 08-MAY-2019, entry version 41. DE RecName: Full=Phosphomannomutase {ECO:0000256|RuleBase:RU361118}; DE EC=5.4.2.8 {ECO:0000256|RuleBase:RU361118}; DE Flags: Fragment; GN Name=PMM2 {ECO:0000313|Ensembl:ENSP00000455320}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000455320, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000455320, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15616553; DOI=10.1038/nature03187; RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., RA Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., RA Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., RA Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., RA Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., RA Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., RA Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., RA Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., RA Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., RA Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., RA Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., RA Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., RA Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., RA Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., RA Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., RA Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., RA Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., RA Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., RA Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., RA Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., RA Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., RA Rubin E.M., Pennacchio L.A.; RT "The sequence and analysis of duplication-rich human chromosome 16."; RL Nature 432:988-994(2004). RN [2] {ECO:0000213|PubMed:21269460} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [3] {ECO:0000313|Ensembl:ENSP00000455320} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. RN [4] {ECO:0000213|PubMed:24275569} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). CC -!- FUNCTION: Involved in the synthesis of the GDP-mannose and CC dolichol-phosphate-mannose required for a number of critical CC mannosyl transfer reactions. {ECO:0000256|RuleBase:RU361118}. CC -!- CATALYTIC ACTIVITY: CC Reaction=alpha-D-mannose 1-phosphate = D-mannose 6-phosphate; CC Xref=Rhea:RHEA:11140, ChEBI:CHEBI:58409, ChEBI:CHEBI:58735; CC EC=5.4.2.8; Evidence={ECO:0000256|RuleBase:RU361118}; CC -!- PATHWAY: Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose CC biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6- CC phosphate: step 2/2. {ECO:0000256|RuleBase:RU361118}. CC -!- SUBUNIT: Homodimer. {ECO:0000256|RuleBase:RU361118}. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU361118}. CC -!- SIMILARITY: Belongs to the eukaryotic PMM family. CC {ECO:0000256|RuleBase:RU361118}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC012173; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR jPOST; H3BPH4; -. DR MaxQB; H3BPH4; -. DR PeptideAtlas; H3BPH4; -. DR PRIDE; H3BPH4; -. DR Ensembl; ENST00000564069; ENSP00000455320; ENSG00000140650. DR UCSC; uc059qpq.1; human. DR HGNC; HGNC:9115; PMM2. DR OpenTargets; ENSG00000140650; -. DR eggNOG; KOG3189; Eukaryota. DR eggNOG; COG0561; LUCA. DR GeneTree; ENSGT00390000002918; -. DR UniPathway; UPA00126; UER00424. DR ChiTaRS; PMM2; human. DR Proteomes; UP000005640; Chromosome 16. DR Bgee; ENSG00000140650; Expressed in 93 organ(s), highest expression level in heart left ventricle. DR ExpressionAtlas; H3BPH4; baseline and differential. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0004615; F:phosphomannomutase activity; IEA:UniProtKB-EC. DR GO; GO:0009298; P:GDP-mannose biosynthetic process; IEA:UniProtKB-UniPathway. DR Gene3D; 3.40.50.1000; -; 1. DR InterPro; IPR036412; HAD-like_sf. DR InterPro; IPR006379; HAD-SF_hydro_IIB. DR InterPro; IPR023214; HAD_sf. DR InterPro; IPR005002; PMM. DR PANTHER; PTHR10466; PTHR10466; 1. DR Pfam; PF03332; PMM; 1. DR SUPFAM; SSF56784; SSF56784; 1. DR TIGRFAMs; TIGR01484; HAD-SF-IIB; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Cytoplasm {ECO:0000256|RuleBase:RU361118}; KW Isomerase {ECO:0000256|RuleBase:RU361118}; KW Proteomics identification {ECO:0000213|EPD:H3BPH4, KW ECO:0000213|MaxQB:H3BPH4, ECO:0000213|PeptideAtlas:H3BPH4}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSP00000455320}. SQ SEQUENCE 142 AA; 16334 MW; A450D931404CC343 CRC64; XFDVDGTLTA PRQKITKEMD DFLQKLRQKI KIGVVGGSDF EKVQEQLGND VVEKYDYVFP ENGLVAYKDG KLLCRQNIQS HLGEALIQDL INYCLSYIAK IKLPKKRGTF IEFRNGMLNV SPIGRSCSQE ERIEFYELDK KI //