ID H3BPH4_HUMAN Unreviewed; 142 AA. AC H3BPH4; DT 18-APR-2012, integrated into UniProtKB/TrEMBL. DT 18-APR-2012, sequence version 1. DT 16-APR-2014, entry version 10. DE RecName: Full=Phosphomannomutase; DE EC=5.4.2.8; DE Flags: Fragment; GN Name=PMM2; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15616553; DOI=10.1038/nature03187; RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., RA Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., RA Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., RA Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., RA Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., RA Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., RA Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., RA Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., RA Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., RA Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., RA Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., RA Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., RA Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., RA Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., RA Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., RA Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., RA Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., RA Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., RA Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., RA Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., RA Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., RA Rubin E.M., Pennacchio L.A.; RT "The sequence and analysis of duplication-rich human chromosome 16."; RL Nature 432:988-994(2004). RN [2] RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- FUNCTION: Involved in the synthesis of the GDP-mannose and CC dolichol-phosphate-mannose required for a number of critical CC mannosyl transfer reactions (By similarity). CC -!- CATALYTIC ACTIVITY: Alpha-D-mannose 1-phosphate = D-mannose 6- CC phosphate. CC -!- PATHWAY: Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose CC biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6- CC phosphate: step 2/2. CC -!- SUBUNIT: Homodimer (By similarity). CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity). CC -!- SIMILARITY: Belongs to the eukaryotic PMM family. CC -!- CAUTION: The sequence shown here is derived from an Ensembl CC automatic analysis pipeline and should be considered as CC preliminary data. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC012173; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENST00000564069; ENSP00000455320; ENSG00000140650. DR HGNC; HGNC:9115; PMM2. DR ChiTaRS; PMM2; human. DR NextBio; 35526112; -. DR GO; GO:0005737; C:cytoplasm; IEA:InterPro. DR GO; GO:0004615; F:phosphomannomutase activity; IEA:InterPro. DR GO; GO:0019307; P:mannose biosynthetic process; IEA:InterPro. DR Gene3D; 3.40.50.1000; -; 1. DR InterPro; IPR023214; HAD-like_dom. DR InterPro; IPR006379; HAD-SF_hydro_IIB. DR InterPro; IPR005002; PMM. DR PANTHER; PTHR10466; PTHR10466; 1. DR Pfam; PF03332; PMM; 1. DR SUPFAM; SSF56784; SSF56784; 1. DR TIGRFAMs; TIGR01484; HAD-SF-IIB; 1. PE 3: Inferred from homology; KW Complete proteome; Cytoplasm; Isomerase; Reference proteome. FT NON_TER 1 1 SQ SEQUENCE 142 AA; 16334 MW; A450D931404CC343 CRC64; XFDVDGTLTA PRQKITKEMD DFLQKLRQKI KIGVVGGSDF EKVQEQLGND VVEKYDYVFP ENGLVAYKDG KLLCRQNIQS HLGEALIQDL INYCLSYIAK IKLPKKRGTF IEFRNGMLNV SPIGRSCSQE ERIEFYELDK KI //