ID H3BPE3_HUMAN Unreviewed; 132 AA. AC H3BPE3; DT 18-APR-2012, integrated into UniProtKB/TrEMBL. DT 05-OCT-2016, sequence version 8. DT 14-DEC-2022, entry version 62. DE SubName: Full=Eukaryotic translation initiation factor 3 subunit C {ECO:0000313|Ensembl:ENSP00000455277.1}; DE Flags: Fragment; GN Name=EIF3C {ECO:0000313|Ensembl:ENSP00000455277.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000455277.1, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000455277.1, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15616553; DOI=10.1038/nature03187; RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., RA Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., RA Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M., RA Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., RA Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., RA Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., RA Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., RA Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., RA Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., RA Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., RA Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., RA Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., RA Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., RA Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., RA Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., RA Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., RA Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., RA DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., RA Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., RA Myers R.M., Rubin E.M., Pennacchio L.A.; RT "The sequence and analysis of duplication-rich human chromosome 16."; RL Nature 432:988-994(2004). RN [2] {ECO:0000313|Ensembl:ENSP00000455277.1} RP IDENTIFICATION. RG Ensembl; RL Submitted (AUG-2022) to UniProtKB. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC145285; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR AlphaFoldDB; H3BPE3; -. DR SMR; H3BPE3; -. DR IntAct; H3BPE3; 1. DR MINT; H3BPE3; -. DR PeptideAtlas; H3BPE3; -. DR ProteomicsDB; 41468; -. DR Antibodypedia; 26523; 260 antibodies from 25 providers. DR Ensembl; ENST00000568426.1; ENSP00000455277.1; ENSG00000184110.15. DR UCSC; uc059son.1; human. DR HGNC; HGNC:3279; EIF3C. DR VEuPathDB; HostDB:ENSG00000184110; -. DR GeneTree; ENSGT00390000017900; -. DR HOGENOM; CLU_1921843_0_0_1; -. DR OMA; VSRTHSI; -. DR ChiTaRS; EIF3C; human. DR Proteomes; UP000005640; Chromosome 16. DR Bgee; ENSG00000184110; Expressed in right uterine tube and 134 other tissues. DR ExpressionAtlas; H3BPE3; baseline and differential. DR GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IEA:InterPro. DR GO; GO:0003723; F:RNA binding; IEA:InterPro. DR GO; GO:0003743; F:translation initiation factor activity; IEA:InterPro. DR GO; GO:0031369; F:translation initiation factor binding; IEA:InterPro. DR InterPro; IPR027516; EIF3C. DR InterPro; IPR008905; EIF3C_N_dom. DR PANTHER; PTHR13937; EUKARYOTIC TRANSLATION INITATION FACTOR 3, SUBUNIT 8 EIF3S8 -RELATED; 1. DR Pfam; PF05470; eIF-3c_N; 1. PE 1: Evidence at protein level; KW Proteomics identification {ECO:0007829|PeptideAtlas:H3BPE3}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}. FT DOMAIN 1..131 FT /note="eIF-3c_N" FT /evidence="ECO:0000259|Pfam:PF05470" FT REGION 82..132 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 99..120 FT /note="Acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT NON_TER 132 FT /evidence="ECO:0000313|Ensembl:ENSP00000455277.1" SQ SEQUENCE 132 AA; 15275 MW; FA8E12D2EFCD1758 CRC64; MKIRDVTKCL EEFELLGKAY GKAKSIVDKE GVPRFYIRIL ADLEDYLNEL WEDKEGKKKM NKNNAKALST LRQKIRKYNR DFESHITSYK QNPEQSADED AEKNEEDSEG SSDEDEDEDG VSAATFLKKK SE //