ID INCA_CHLCV Reviewed; 355 AA. AC H2VFV1; DT 16-JAN-2019, integrated into UniProtKB/Swiss-Prot. DT 21-MAR-2012, sequence version 1. DT 16-OCT-2019, entry version 40. DE RecName: Full=Inclusion membrane protein A {ECO:0000303|PubMed:15316015}; GN Name=incA; OrderedLocusNames=CCA_00550; OS Chlamydophila caviae (strain ATCC VR-813 / DSM 19441 / GPIC) OS (Chlamydia caviae). OC Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae; OC Chlamydia/Chlamydophila group; Chlamydia. OX NCBI_TaxID=227941; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC VR-813 / DSM 19441 / GPIC; RX PubMed=12682364; DOI=10.1093/nar/gkg321; RA Read T.D., Myers G.S.A., Brunham R.C., Nelson W.C., Paulsen I.T., RA Heidelberg J.F., Holtzapple E.K., Khouri H.M., Federova N.B., RA Carty H.A., Umayam L.A., Haft D.H., Peterson J.D., Beanan M.J., RA White O., Salzberg S.L., Hsia R.-C., McClarty G., Rank R.G., RA Bavoil P.M., Fraser C.M.; RT "Genome sequence of Chlamydophila caviae (Chlamydia psittaci GPIC): RT examining the role of niche-specific genes in the evolution of the RT Chlamydiaceae."; RL Nucleic Acids Res. 31:2134-2147(2003). RN [2] RP SUBUNIT, OLIGOMERIZATION, DOMAIN, AND MUTAGENESIS BY DOMAIN DELETION. RC STRAIN=ATCC VR-813 / DSM 19441 / GPIC; RX PubMed=15316015; DOI=10.1074/jbc.m407227200; RA Delevoye C., Nilges M., Dautry-Varsat A., Subtil A.; RT "Conservation of the biochemical properties of IncA from Chlamydia RT trachomatis and Chlamydia caviae: oligomerization of IncA mediates RT interaction between facing membranes."; RL J. Biol. Chem. 279:46896-46906(2004). CC -!- FUNCTION: Chlamydia replicate within a host intracellular vacuole, CC termed an inclusion, which is formed by fusion of many smaller CC inclusion bodies. IncA is probably involved in the homotypic CC fusion of inclusions. {ECO:0000250|UniProtKB:A0A0H3MD02}. CC -!- SUBUNIT: Form homodimers, and probably higher-order oligomers too. CC {ECO:0000269|PubMed:15316015}. CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:A0A0H3MD02}. CC Host vacuole, Host pathogen-containing vacuole, Host pathogen- CC containing vacuole membrane {ECO:0000305|PubMed:15316015}; Multi- CC pass membrane protein {ECO:0000255}. Note=Secreted, probably by a CC type III secretion system (By similarity). Localized in the CC inclusion membrane (Probable). In the inclusion, the C-terminus CC faces the host cytosol (Probable). CC {ECO:0000250|UniProtKB:A0A0H3MD02, ECO:0000305|PubMed:15316015}. CC -!- DOMAIN: IncA proteins share the same general organization: a short CC N-terminal domain, a large bilobed hydrophobic domain, and a C- CC terminal cytoplasmic domain. {ECO:0000305|PubMed:15316015}. CC -!- SIMILARITY: Belongs to the IncA family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE015925; AAP05293.1; -; Genomic_DNA. DR RefSeq; WP_011006508.1; NC_003361.3. DR STRING; 227941.CCA_00550; -. DR EnsemblBacteria; AAP05293; AAP05293; CCA_00550. DR KEGG; cca:CCA_00550; -. DR OMA; QHETSLQ; -. DR OrthoDB; 1498440at2; -. DR BioCyc; CCAV227941:G1G03-563-MONOMER; -. DR Proteomes; UP000002193; Chromosome. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-KW. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0140221; C:pathogen-containing vacuole membrane; IEA:UniProtKB-SubCell. PE 1: Evidence at protein level; KW Coiled coil; Complete proteome; Host membrane; Membrane; Secreted; KW Transmembrane; Transmembrane helix. FT CHAIN 1 355 Inclusion membrane protein A. FT /FTId=PRO_0000446190. FT TRANSMEM 67 91 Helical. {ECO:0000255}. FT TRANSMEM 97 117 Helical. {ECO:0000255}. FT REGION 54 118 Required for membrane anchoring. FT {ECO:0000269|PubMed:15316015}. FT COILED 243 298 {ECO:0000255}. SQ SEQUENCE 355 AA; 38802 MW; 335AAD114D226351 CRC64; MTVSTDNTSP VISRASSPTF GDHGKDFDNN KIIPISIEAP TSSAAAVGAK TAIEPEGRSP LLQRICYLVK IIAAIALFVV GIAALVCLYL GSVISTPSLI LMLAIMLVSF VIVITAIRDG TPSQVVRHMK QQIQQFGEEN TRLHTAVENL KAVNVELSEQ INQLKQLHTR LSDFGDRLEA NTGDFTALIA DFQLSLEEFK SVGTKVETML SPFEKLAQSL KETFSQEAVQ AMMSSVTELR TNLNALKELI TENKTVIEQL KADAQLREEQ VRFLEKRKQE LEEACSTLSH SIATLQESTT LLKDSTTNLH AVESRLIGVM VQDGAESSTV EEASQDDSAQ PQDENQSDAG EHKDS //