ID H2MWP8_ORYLA Unreviewed; 118 AA. AC H2MWP8; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 21-MAR-2012, sequence version 1. DT 27-MAR-2024, entry version 52. DE RecName: Full=Galanin peptides {ECO:0000256|ARBA:ARBA00019079}; GN Name=gal {ECO:0000313|EMBL:BCB22969.1, GN ECO:0000313|Ensembl:ENSORLP00000023304.1}; OS Oryzias latipes (Japanese rice fish) (Japanese killifish). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae; OC Oryzias. OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000023304.1, ECO:0000313|Proteomes:UP000001038}; RN [1] {ECO:0000313|Ensembl:ENSORLP00000023304.1, ECO:0000313|Proteomes:UP000001038} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000023304.1, RC ECO:0000313|Proteomes:UP000001038}; RX PubMed=17554307; DOI=10.1038/nature05846; RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T., RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A., RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S., RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S., RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K., RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.; RT "The medaka draft genome and insights into vertebrate genome evolution."; RL Nature 447:714-719(2007). RN [2] {ECO:0000313|EMBL:BCB22969.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=D-rR {ECO:0000313|EMBL:BCB22969.1}; RC TISSUE=Brain {ECO:0000313|EMBL:BCB22969.1}; RA Yamashita J., Takeuchi A., Hosono K., Fleming T., Nagahama Y., Okubo K.; RT "Male-predominant galanin mediates androgen-dependent aggressive chases in RT medaka."; RL Elife 9:0-e59470(2020). RN [3] {ECO:0000313|Ensembl:ENSORLP00000023304.1} RP IDENTIFICATION. RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000023304.1}; RG Ensembl; RL Submitted (NOV-2023) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}. CC -!- SIMILARITY: Belongs to the galanin family. CC {ECO:0000256|ARBA:ARBA00006871}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; LC532140; BCB22969.1; -; mRNA. DR RefSeq; XP_004086257.1; XM_004086209.2. DR Ensembl; ENSORLT00000023305.2; ENSORLP00000023304.1; ENSORLG00000018643.2. DR GeneID; 101157924; -. DR KEGG; ola:101157924; -. DR CTD; 51083; -. DR GeneTree; ENSGT00390000009663; -. DR HOGENOM; CLU_166244_0_0_1; -. DR OrthoDB; 4119714at2759; -. DR Proteomes; UP000001038; Chromosome 6. DR Bgee; ENSORLG00000018643; Expressed in brain and 10 other cell types or tissues. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW. DR GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW. DR InterPro; IPR008174; Galanin. DR InterPro; IPR008175; Galanin_pre. DR InterPro; IPR013068; GMAP. DR PANTHER; PTHR16839; GALANIN; 1. DR PANTHER; PTHR16839:SF1; GALANIN PEPTIDES; 1. DR Pfam; PF01296; Galanin; 1. DR Pfam; PF06540; GMAP; 1. DR PRINTS; PR00273; GALANIN. DR SMART; SM00071; Galanin; 1. DR PROSITE; PS00861; GALANIN; 1. PE 2: Evidence at transcript level; KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685}; KW Neuropeptide {ECO:0000256|ARBA:ARBA00023320}; KW Reference proteome {ECO:0000313|Proteomes:UP000001038}; KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}. FT SIGNAL 1..19 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 20..118 FT /note="Galanin peptides" FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5041117509" FT DOMAIN 33..45 FT /note="Galanin" FT /evidence="ECO:0000259|PROSITE:PS00861" SQ SEQUENCE 118 AA; 12767 MW; 11B5D641C9C26622 CRC64; MHKCLGILCA SLIFCAALSE SIGLVIAAKE KRGWTLNSAG YLLGPHGIDG HRTLGDKQGL AGKRDMGQEE DFRPGSLRIA DEDIIHTVVD FLSYLKLKEM GALENLPPSV TSDEMTNP //