ID H1UUR5_DROME Unreviewed; 883 AA. AC H1UUR5; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 21-MAR-2012, sequence version 1. DT 03-MAY-2023, entry version 58. DE SubName: Full=FI19001p1 {ECO:0000313|EMBL:AEZ00751.1}; GN Name=Eip74EF-RD {ECO:0000313|EMBL:AEZ00751.1}; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; OC Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AEZ00751.1}; RN [1] {ECO:0000313|EMBL:AEZ00751.1} RP NUCLEOTIDE SEQUENCE. RA Carlson J., Booth B., Frise E., Park S., Wan K., Yu C., Celniker S.; RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases. CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123, CC ECO:0000256|RuleBase:RU004019}. CC -!- SIMILARITY: Belongs to the ETS family. {ECO:0000256|ARBA:ARBA00005562, CC ECO:0000256|RuleBase:RU004019}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BT133150; AEZ00751.1; -; mRNA. DR RefSeq; NP_001014590.1; NM_001014590.2. DR RefSeq; NP_730288.1; NM_168741.2. DR AlphaFoldDB; H1UUR5; -. DR SMR; H1UUR5; -. DR EnsemblMetazoa; FBtr0075204; FBpp0074967; FBgn0000567. DR EnsemblMetazoa; FBtr0100411; FBpp0099825; FBgn0000567. DR GeneID; 39962; -. DR KEGG; dme:Dmel_CG32180; -. DR CTD; 39962; -. DR VEuPathDB; VectorBase:FBgn0000567; -. DR HOGENOM; CLU_014368_0_0_1; -. DR OMA; THCERAR; -. DR OrthoDB; 4245771at2759; -. DR PhylomeDB; H1UUR5; -. DR BioGRID-ORCS; 39962; 0 hits in 3 CRISPR screens. DR GenomeRNAi; 39962; -. DR Bgee; FBgn0000567; Expressed in embryonic/larval hemocyte (Drosophila) and 22 other tissues. DR ExpressionAtlas; H1UUR5; baseline and differential. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro. DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro. DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro. DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1. DR InterPro; IPR000418; Ets_dom. DR InterPro; IPR046328; ETS_fam. DR InterPro; IPR036388; WH-like_DNA-bd_sf. DR InterPro; IPR036390; WH_DNA-bd_sf. DR PANTHER; PTHR11849:SF191; ECDYSONE-INDUCED PROTEIN 74EF ISOFORM B; 1. DR PANTHER; PTHR11849; ETS; 1. DR Pfam; PF00178; Ets; 1. DR PRINTS; PR00454; ETSDOMAIN. DR SMART; SM00413; ETS; 1. DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1. DR PROSITE; PS00345; ETS_DOMAIN_1; 1. DR PROSITE; PS00346; ETS_DOMAIN_2; 1. DR PROSITE; PS50061; ETS_DOMAIN_3; 1. PE 2: Evidence at transcript level; KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004019}; KW Nucleus {ECO:0000256|RuleBase:RU004019}. FT DOMAIN 787..869 FT /note="ETS" FT /evidence="ECO:0000259|PROSITE:PS50061" FT REGION 19..207 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 223..264 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 299..321 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 355..383 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 407..437 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 450..497 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 562..587 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 612..695 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 19..61 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 62..77 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 92..119 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 133..157 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 191..207 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 223..238 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 243..264 FT /note="Acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 459..493 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 563..587 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 612..672 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 883 AA; 94811 MW; 063AA031A18D1409 CRC64; MIMVQHLVAA SAHNFASQAA ASLVNVSSSS SSSSSSSSSS LSLSSSSSSS SLSSATPTPV ASPVTPTSPP PAAAAPAEAS PPAGAELQED GQQAKTQEDP TMKDQDMLEK TRQEVKDPVN VEEPGAIVDT ESVMARQSPS PVASTKVPES LEEISNKSPP VQEDEEESES VASDCREFKV LYNHLRQQQH HHSPSSPDKT RSTLDDVSKI LWERKQQLQR SSVITAAPTL QPQQHQQPMS DIEDEETLED VDDADADVEA DAEDEELLEQ YQNGYDSPLD LSLGGATSAA ASAAAAASAV SRRRGRTYSG TESDDSAQCE RARMRLKPER KAERSAAYKK SLMKRYYTEI PIVKQSTSPA PQQQLQQQHH LQQQQQQQPH NGSTFAGATA LLHIKTEQNT LLTPLQLQQQ QQQQQGLHGA AGNGGSSNGN NAHQQQQPLA IPQRPLLHNL LSGGAIHNPH HRNYTTATTG SFPPSPADSG VSDVDSSSSG GQPCADELKA RLGMPPATSA SAAAAAAAAA AAAAHLHTGT FLHPNLYQNN AANSLRNIWN RSVGVPDNYY GSSGAGSGGT QPGGPGNPQT PGYLTTSYFN APTAATAAAS QRGTTINGYH SLHQQQQQQQ QSQQSQQQQQ LAHQQLSHQQ QQALHQQLSH QQQQQQQQQQ QHPHSQLNGP HPHSHPHSHP HSHPHAGQHT HSTIAAAAAA AAASVVSSSS SAVAAAAMLS ASAAAAATAA AAAGGSQSVI QPATSSVSYD LSYMLELGGF QQRKAKKPRK PKLEMGVKRR SREGSTTYLW EFLLKLLQDR EYCPRFIKWT NREKGVFKLV DSKAVSRLWG MHKNKPDMNY ETMGRALRYY YQRGILAKVD GQRLVYQFVD VPKDIIEIDC NGV //