ID H1KWJ9_9EURY Unreviewed; 179 AA. AC H1KWJ9; DT 21-MAR-2012, integrated into UniProtKB/TrEMBL. DT 21-MAR-2012, sequence version 1. DT 20-JAN-2016, entry version 13. DE RecName: Full=CDP-archaeol synthase {ECO:0000256|HAMAP-Rule:MF_01117}; DE EC=2.7.7.67 {ECO:0000256|HAMAP-Rule:MF_01117}; DE AltName: Full=CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol synthase {ECO:0000256|HAMAP-Rule:MF_01117}; GN Name=carS {ECO:0000256|HAMAP-Rule:MF_01117}; GN ORFNames=MetfoDRAFT_0172 {ECO:0000313|EMBL:EHP89576.1}; OS Methanotorris formicicus Mc-S-70. OC Archaea; Euryarchaeota; Methanococci; Methanococcales; OC Methanocaldococcaceae; Methanotorris. OX NCBI_TaxID=647171 {ECO:0000313|EMBL:EHP89576.1}; RN [1] {ECO:0000313|EMBL:EHP89576.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Mc-S-70 {ECO:0000313|EMBL:EHP89576.1}; RG US DOE Joint Genome Institute (JGI-PGF); RA Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., RA Peters L., Land M.L., Hauser L., Sieprawska-Lupa M., Takai K., RA Miyazaki J., Whitman W., Woyke T.J.; RT "The draft genome of Methanotorris formicicus Mc-S-70."; RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Catalyzes the formation of CDP-2,3-bis-(O- CC geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O- CC geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This CC reaction is the third ether-bond-formation step in the CC biosynthesis of archaeal membrane lipids. {ECO:0000256|HAMAP- CC Rule:MF_01117}. CC -!- CATALYTIC ACTIVITY: CTP + 2,3-bis-(O-geranylgeranyl)-sn-glycerol CC 1-phosphate = diphosphate + CDP-2,3-bis-(O-geranylgeranyl)-sn- CC glycerol. {ECO:0000256|HAMAP-Rule:MF_01117}. CC -!- COFACTOR: CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000256|HAMAP- CC Rule:MF_01117}; CC -!- PATHWAY: Membrane lipid metabolism; glycerophospholipid CC metabolism. {ECO:0000256|HAMAP-Rule:MF_01117}. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|HAMAP- CC Rule:MF_01117, ECO:0000256|SAAS:SAAS00100496}; Multi-pass membrane CC protein {ECO:0000256|HAMAP-Rule:MF_01117, CC ECO:0000256|SAAS:SAAS00100496}. CC -!- SIMILARITY: Belongs to the CDP-archaeol synthase family. CC {ECO:0000256|HAMAP-Rule:MF_01117}. CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:EHP89576.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AGJL01000002; EHP89576.1; -; Genomic_DNA. DR RefSeq; WP_007043618.1; NZ_AGJL01000002.1. DR EnsemblBacteria; EHP89576; EHP89576; MetfoDRAFT_0172. DR UniPathway; UPA00940; -. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR HAMAP; MF_01117; UPF0290; 1. DR InterPro; IPR032690; CarS-like. DR InterPro; IPR002726; CarS_archaea. DR Pfam; PF01864; DUF46; 1. PE 3: Inferred from homology; KW Cell membrane {ECO:0000256|HAMAP-Rule:MF_01117, KW ECO:0000256|SAAS:SAAS00414404}; KW Lipid biosynthesis {ECO:0000256|HAMAP-Rule:MF_01117}; KW Lipid metabolism {ECO:0000256|HAMAP-Rule:MF_01117}; KW Magnesium {ECO:0000256|HAMAP-Rule:MF_01117}; KW Membrane {ECO:0000256|HAMAP-Rule:MF_01117, KW ECO:0000256|SAAS:SAAS00414403}; KW Phospholipid biosynthesis {ECO:0000256|HAMAP-Rule:MF_01117}; KW Phospholipid metabolism {ECO:0000256|HAMAP-Rule:MF_01117}; KW Transferase {ECO:0000256|HAMAP-Rule:MF_01117}; KW Transmembrane {ECO:0000256|HAMAP-Rule:MF_01117, KW ECO:0000256|SAAS:SAAS00414406}; KW Transmembrane helix {ECO:0000256|HAMAP-Rule:MF_01117, KW ECO:0000256|SAAS:SAAS00414407}. FT TRANSMEM 3 23 Helical. {ECO:0000256|HAMAP-Rule: FT MF_01117}. FT TRANSMEM 58 78 Helical. {ECO:0000256|HAMAP-Rule: FT MF_01117}. FT TRANSMEM 92 112 Helical. {ECO:0000256|HAMAP-Rule: FT MF_01117}. FT TRANSMEM 132 152 Helical. {ECO:0000256|HAMAP-Rule: FT MF_01117}. FT TRANSMEM 154 174 Helical. {ECO:0000256|HAMAP-Rule: FT MF_01117}. SQ SEQUENCE 179 AA; 19704 MW; 3E7D148731554E47 CRC64; MDIVGLVFSS FWYILPAYIA NATACIFGGG TPLDLGRNFI DGRRLIGNGV TFRGTFSGIL CGTIAAILQG VILNLKIINT PMVFYSNIFE CAFLGFLLSS GALFGDMVGS FIKRRLEIKQ GNPAPILDQL NFVFGAILFT YPFSPLPLNM IITICVITPI IHLTSNIIAY KLKIKKVWW //