ID H0ZTL7_TAEGU Unreviewed; 420 AA. AC H0ZTL7; DT 22-FEB-2012, integrated into UniProtKB/TrEMBL. DT 17-JUN-2020, sequence version 2. DT 12-AUG-2020, entry version 54. DE RecName: Full=Acyltransferase {ECO:0000256|RuleBase:RU367023}; DE EC=2.3.1.- {ECO:0000256|RuleBase:RU367023}; GN Name=DGAT2 {ECO:0000313|Ensembl:ENSTGUP00000013963}; OS Taeniopygia guttata (Zebra finch) (Poephila guttata). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae; OC Estrildinae; Taeniopygia. OX NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000013963, ECO:0000313|Proteomes:UP000007754}; RN [1] {ECO:0000313|Ensembl:ENSTGUP00000013963, ECO:0000313|Proteomes:UP000007754} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=20360741; DOI=10.1038/nature08819; RA Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W., RA Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A., RA Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P., RA Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C., London S.E., RA Li Y., Lin Y.C., George J., Sweedler J., Southey B., Gunaratne P., RA Watson M., Nam K., Backstrom N., Smeds L., Nabholz B., Itoh Y., Whitney O., RA Pfenning A.R., Howard J., Volker M., Skinner B.M., Griffin D.K., Ye L., RA McLaren W.M., Flicek P., Quesada V., Velasco G., Lopez-Otin C., RA Puente X.S., Olender T., Lancet D., Smit A.F., Hubley R., Konkel M.K., RA Walker J.A., Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z., RA Eichler E.E., Stapley J., Slate J., Ekblom R., Birkhead T., Burke T., RA Burt D., Scharff C., Adam I., Richard H., Sultan M., Soldatov A., RA Lehrach H., Edwards S.V., Yang S.P., Li X., Graves T., Fulton L., RA Nelson J., Chinwalla A., Hou S., Mardis E.R., Wilson R.K.; RT "The genome of a songbird."; RL Nature 464:757-762(2010). RN [2] {ECO:0000313|Ensembl:ENSTGUP00000013963} RP IDENTIFICATION. RG Ensembl; RL Submitted (JAN-2012) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane CC {ECO:0000256|RuleBase:RU367023}; Multi-pass membrane protein CC {ECO:0000256|RuleBase:RU367023}. CC -!- SIMILARITY: Belongs to the diacylglycerol acyltransferase family. CC {ECO:0000256|ARBA:ARBA00005420, ECO:0000256|RuleBase:RU367023}. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of CC feature annotation. {ECO:0000256|RuleBase:RU367023}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR Ensembl; ENSTGUT00000014122; ENSTGUP00000013963; ENSTGUG00000013562. DR GeneTree; ENSGT01000000214618; -. DR HOGENOM; CLU_023995_0_0_1; -. DR InParanoid; H0ZTL7; -. DR OMA; LIYMFCT; -. DR OrthoDB; 1347007at2759; -. DR TreeFam; TF314707; -. DR Proteomes; UP000007754; Chromosome 1. DR GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; IEA:Ensembl. DR GO; GO:0005811; C:lipid droplet; IEA:Ensembl. DR GO; GO:0005739; C:mitochondrion; IEA:Ensembl. DR GO; GO:1990578; C:perinuclear endoplasmic reticulum membrane; IEA:Ensembl. DR GO; GO:0003846; F:2-acylglycerol O-acyltransferase activity; IEA:Ensembl. DR GO; GO:0004144; F:diacylglycerol O-acyltransferase activity; IEA:Ensembl. DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl. DR GO; GO:0071400; P:cellular response to oleic acid; IEA:Ensembl. DR GO; GO:0035356; P:cellular triglyceride homeostasis; IEA:Ensembl. DR GO; GO:0042632; P:cholesterol homeostasis; IEA:Ensembl. DR GO; GO:0046339; P:diacylglycerol metabolic process; IEA:Ensembl. DR GO; GO:0060613; P:fat pad development; IEA:Ensembl. DR GO; GO:0055089; P:fatty acid homeostasis; IEA:Ensembl. DR GO; GO:0019915; P:lipid storage; IEA:Ensembl. DR GO; GO:0035336; P:long-chain fatty-acyl-CoA metabolic process; IEA:Ensembl. DR GO; GO:0034383; P:low-density lipoprotein particle clearance; IEA:Ensembl. DR GO; GO:0019432; P:triglyceride biosynthetic process; IEA:Ensembl. DR InterPro; IPR007130; DAGAT. DR Pfam; PF03982; DAGAT; 1. PE 3: Inferred from homology; KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315}; KW Endoplasmic reticulum {ECO:0000256|RuleBase:RU367023}; KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516}; KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022516}; KW Membrane {ECO:0000256|RuleBase:RU367023}; KW Reference proteome {ECO:0000313|Proteomes:UP000007754}; KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU367023}; KW Transmembrane {ECO:0000256|RuleBase:RU367023}; KW Transmembrane helix {ECO:0000256|RuleBase:RU367023}. FT TRANSMEM 102..126 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU367023" FT REGION 1..24 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 420 AA; 46491 MW; 7A02905082720859 CRC64; MPRAGLGPGK RSGPAPSPPP SVSSSSSLGY IWVLGSAPLR GGGGARCAAP SIPWPCPEPP PTMKTIIAAY SGVLRGTGSN ILSALQDLFW LLKSKAEKQL QIISVLQWVL TFLIMGIACT LILMYILCTD CWAIAALYLA WLVFDWNTPK KGGRRSQWVR NWAIWRYFRD YFPIRLVKTH NLLTTRNYIF GYHPHGIMGL GAFCNFSTEA TGVGQKFPGI RPYLATLAGN FRMPILRDYL MSGGICPVNR DSIDYILSKN GSGNAIIIVV GGAAESLNCT PGKNSVTLKN RKGFVKLALR HGADLVPVYS FGENEVYKQV IFEEGSWGRW VQKKFQKHIG FAPCIFHGRG LFSSNTWGLL PYSKPITTVV GEPITIPKID NPSQKDVDFY HSMYVDSLIK LFDKYKSKFG LPETEVLEVN //